CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3626
Family Name cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SCH-57726 Family
No. of Seeds 9 No. of Other Members 29
Family Centroid CFAMM00294845 Functional Category Investigative Drug
Superfamily Adenosine receptor A2a and Amine oxidase [flavin-containing] B Binder Superfamily
Class Class 1027

Cousin Family NamesSeedsMembers
Adenosine receptor A2a Ligand KW-6002 Family 18 195
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Inhibitor Arof... 3 196
Dipeptidyl peptidase 4 Inhibitor SSR-162369 Family 8 27
GP-531 family 1 33
Toll-like receptor 7 Ligand GS-9620 Family 2 4
Adenosine receptor A1 and Adenosine receptor A2a Ligand 8-phen... 12 213
Adenosine receptor A1 and Adenosine receptor A2b Ligand PSB-11... 34 26
Herpes simplex virus type 1 thymidine kinase Inhibitor 9-(4-hy... 2 13
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Adenosine receptor A2b Ligand CVT-7124 Family 14 64
Adenosine receptor A2a Ligand (e,e)-8-(4-phenylbutadien-1-yl)c... 11 43
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 6 14
Herpes simplex virus type 1 thymidine kinase Inhibitor N2-(3-t... 1 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN1... 6 16
Adenosine receptor A1 ligand 4-[5-(8-cyclopentyl-2,6-dioxo-1-p... 3 4
Adenosine receptor A1 ligand SureCN10614388 family 5 1
Adenosine receptor A1 ligand 8-(2-amino-4-nitrophenyl)-1,3-dim... 1 0
Adenosine receptor A1 and Adenosine receptor A2b ligand 3-meth... 7 19
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 2 1
Dipeptidyl peptidase 4 inhibitor Xanthine Analogue 4 family 1 4
Dipeptidyl peptidase 4 inhibitor AGN-PC-046QKE family 3 5
Dipeptidyl peptidase 4 inhibitor Xanthine mimetic compound 8 f... 2 2
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 27
Vascular endothelial growth factor receptor 2 ligand AC1LLCDM ... 1 2
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Prelamin-A/C inhibitor CHEMBL1503535 family 1 0
Cellular tumor antigen p53 and Thyrotropin receptor ligand CHE... 1 5
Adenosine receptor A3 and Adenosine receptor A1 ligand (8R)-8-... 4 0
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 18
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 2 2
Toll-like receptor 7 ligand 6-amino-2-(butylamino)-9-[[4-(dime... 5 4
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 9 6
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 4 8
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 10 14
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 1 0
C-X-C chemokine receptor type 3 ligand 3-amino-6-chloro-5-[(3S... 11 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Sodium- and chloride-dependent glycine transporter 1 and Sodiu... 4 8
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 13 2
Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fl... 4 3
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Adenosine receptor A3 ligand 3-(cyclopropylmethyl)-8-methoxy-1... 1 0
G-protein coupled bile acid receptor 1 ligand 2-(ethylamino)-6... 5 4
Orexin receptor type 2 and Orexin receptor type 1 ligand (2R)-... 12 16
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 1 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 35 14
Prothrombin inhibitor 2-[4-methyl-5-[[[2-[6-methyl-2-oxo-3-(2-... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 2
Adenosine receptor A1 ligand 3-(4-Aminophenethyl)-8-(3-noradam... 1 0
Gonadotropin-releasing hormone receptor and 5-hydroxytryptamin... 2 0
B1 bradykinin receptor ligand AGN-PC-077LWO family 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 9 0
Dipeptidyl peptidase 4 inhibitor AGN-PC-046QKJ family 1 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-02ZKZ9... 9 12
Adenosine receptor A2a and Adenosine receptor A1 ligand 3,7-di... 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00294840 CHEMBL281087 Bioactive CHEMBL281087
CFAMM00294845 DNC012753 Investigative Drug SCH-57726

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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