CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3631
Family Name Genome polyprotein Inhibitor Acasp-glu-dif-glu-cha-cys Family
No. of Seeds 13 No. of Other Members 17
Family Centroid CFAMM00295003 Functional Category Investigative Drug
Superfamily Vasopressin V1a receptor Ligand Felypressin Superfamily
Class Class 168

Cousin Family NamesSeedsMembers
Vasopressin V2 receptor ligand peptide analog Desmopressin family 111 1472
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Penicillin binding protein inhibitor β-lactam aminopenicillin ... 12 359
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
Growth hormone-releasing hormone receptor ligand polypeptide ... 14 34
Atrial natriuretic peptide receptor 1 Ligand Nesiritide Family 6 111
Bacterial outer membrane Inhibitor Polymyxin B Family 17 181
Thymopentin family 20 133
Angiotensin-converting enzyme and Neprilysin Inhibitor M100,24... 18 60
Thymosin Beta-4 family 8 30
Melanocortin receptor 4 Ligand Ro-27-3225 Family 6 52
Integrin alpha-V and Integrin beta-3 Inhibitor C[rgd-(s)-alpha... 19 95
Renin Inhibitor CP-80794 Family 16 112
Neprilysin Inhibitor Thiorphan Family 41 68
Neuromedin-K receptor Ligand Senktide Family 15 22
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Gamma-g... 2 1
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Disintegrin and metalloproteinase domain-containing protein 17... 8 7
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Nociceptin receptor Ligand Fggftgcrkscrk Family 10 0
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Beta-secretase 1 Inhibitor Glu-leu-asp-leu-(choh-ch2)-ala-ala-... 15 11
Calcitonin gene-related peptide type 1 receptor Ligand Fvptdvg... 8 8
Caspase-1 Inhibitor Z-vad-cho Family 8 34
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Beta-secretase 1 Inhibitor KMI-172 Family 3 0
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Disks large homolog 4 Inhibitor N-(3,4-difluorophenyl)propyl-e... 3 0
Substance-P receptor Ligand [sar9,met(o2)11]-sp Family 34 9
Integrin alpha-V Inhibitor C[rgdf-(3s)-carboxymorpholine] Family 10 2
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-154957 Family 2 3
Receptor-type tyrosine-protein phosphatase C Ligand Asp-brpmp-... 2 0
Endothelin-converting enzyme 1 Inhibitor PO3 2-leu-nal-o-3k Fa... 3 26
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Genome polyprotein Inhibitor Acasp-glu-met-glu-cha-cys Family 3 6
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Serine/threonine protein phosphatase PP1-alpha 1 catalytic sub... 10 0
Neprilysin and Aminopeptidase N inhibitor (2S)-2-[[(2S)-2-[[[a... 13 1
Glutamate receptor ionotropic, kainate 2 ligand (2S,3S,4S)-4-[... 14 2
NS3 and Non-structural protein 4A inhibitor (4S)-4-[[(2S)-3-ca... 1 1
Caspase-1 inhibitor (3S)-3-[[(2S)-4-(2-naphthalen-1-ylethylami... 1 0
Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73
Neprilysin inhibitor SureCN489232 family 3 9
Neprilysin inhibitor (2S)-2-methyl-3-oxo-3-[[(2S)-1-phenyl-3-s... 5 2
Growth factor receptor-bound protein 2 ligand 2-[(9S,10S,11E,1... 5 14
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-cycl... 1 6
Tryptase alpha/beta-1 inhibitor methyl 3-[3-(aminomethyl)pheny... 1 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Endothelin-converting enzyme 1 and Cathepsin D inhibitor N-[(2... 6 2
Pol polyprotein inhibitor benzyl N-[(2S)-4-amino-1-[[(2S,3R)-4... 2 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2S,4R)... 5 8
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R,6S,12S)-6... 7 0
Neprilysin inhibitor SureCN7437961 family 2 6
Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3R)-1-cyclohexyl-3-h... 2 0
Tyrosine-protein phosphatase non-receptor type 1 and Tyrosine-... 1 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor (3R)-3-... 3 2
Angiotensin-converting enzyme and Leukotriene A-4 hydrolase in... 7 1
Calpain-1 catalytic subunit inhibitor Peptidyl alpha-Ketoacid,... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 6
Ribonucleoside-diphosphate reductase large subunit and Ribonuc... 1 0
Beta-secretase 1 inhibitor 3-[[[(2S)-2-[[(3S,4S)-3-hydroxy-6-m... 2 4
Bcl-2-like protein 1 inhibitor CHEMBL501005 family 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00295011 CHEMBL265015 Bioactive AC1LA5GM
CFAMM00295025 CHEMBL160002 Bioactive AC1L9WG4
CFAMM00295017 CHEMBL409677 Bioactive AC1L9V5I
CFAMM00295027 CHEMBL162028 Bioactive AC1LAQKD
CFAMM00295006 DNC012833 Investigative Drug AcAsp-Glu-Dif-Ile-Cha-Cys-Pro-Nle-Asp-ValNH2
CFAMM00295020 DNC012776 Investigative Drug AcAsp-Glu-Dif-Lys-Cha-Cys
CFAMM00294999 DNC012826 Investigative Drug AcAsp-Glu-Dif-Glu-Cha-Fab
CFAMM00295005 DNC012834 Investigative Drug AcAsp-Glu-Dif-Ile-Cha-Cys-Pro-Cha-Asp-ValNH2
CFAMM00295004 DNC012764 Investigative Drug AcGlu-Dif-Ile-Cha-Cys
CFAMM00295010 DNC012795 Investigative Drug AcGlu-Dif-Glu-Cha-Cys
CFAMM00295003 DNC012767 Investigative Drug AcAsp-Glu-Dif-Glu-Cha-Cys
CFAMM00295021 DNC012779 Investigative Drug AcDif-Glu-Cha-Cys
CFAMM00295013 DNC012781 Investigative Drug AcAsp-Glu-Dif-Ile-Cha-Cys

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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