Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database. Cousin Family Names Seeds Members Vasopressin V2 receptor ligand peptide analog Desmopressin family 111 1472 Vasopressin V1a receptor Ligand Felypressin Family 12 820 Oxytocin receptor Ligand Oxytocin Family 30 182 Penicillin binding protein inhibitor β-lactam aminopenicillin ... 12 359 Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443 Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374 Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86 Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54 ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233 Growth hormone-releasing hormone receptor ligand polypeptide ... 14 34 Atrial natriuretic peptide receptor 1 Ligand Nesiritide Family 6 111 Bacterial outer membrane Inhibitor Polymyxin B Family 17 181 Thymopentin family 20 133 Angiotensin-converting enzyme and Neprilysin Inhibitor M100,24... 18 60 Thymosin Beta-4 family 8 30 Ezatiostat family 1 4 Melanocortin receptor 4 Ligand Ro-27-3225 Family 6 52 Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151 72 kDa type IV collagenase Inhibitor Batimastat Family 6 52 Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80 Integrin alpha-V and Integrin beta-3 Inhibitor C[rgd-(s)-alpha... 19 95 Neprilysin Inhibitor Thiorphan Family 41 68 Vasopeptidase Inhibitor Sampatrilat Family 25 9 Neuromedin-K receptor Ligand Senktide Family 15 22 cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Gamma-g... 2 1 Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131 Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55 Beta-secretase 1 Inhibitor MMI-175 Family 30 137 Proto-oncogene tyrosine-protein kinase Src Inhibitor Glu-pro-g... 8 4 Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82 Plasmepsin-1 Inhibitor SC-5003 Family 93 173 Nociceptin receptor Ligand Fggftgcrkscrk Family 10 0 Neuromedin-K receptor Ligand PD-157672 Family 9 37 Beta-secretase 1 Inhibitor Glu-leu-asp-leu-(choh-ch2)-ala-ala-... 15 11 Calcitonin gene-related peptide type 1 receptor Ligand Fvptdvg... 8 8 Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51 Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12 Melanocortin receptor 4 and Substance-K receptor Ligand Hoo-ph... 3 19 Beta-secretase 1 Inhibitor KMI-172 Family 3 0 Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24 Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21 Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10 Disks large homolog 4 Inhibitor N-(3,4-difluorophenyl)propyl-e... 3 0 Substance-P receptor Ligand [sar9,met(o2)11]-sp Family 34 9 Integrin alpha-V Inhibitor C[rgdf-(3s)-carboxymorpholine] Family 10 2 Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6 DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-154957 Family 2 3 Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28 Endothelin-converting enzyme 1 Inhibitor PO3 2-leu-nal-o-3k Fa... 3 26 Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19 Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8 Protein farnesyltransferase subunit beta Inhibitor L-739750 Fa... 4 0 Genome polyprotein Inhibitor Acasp-glu-dif-glu-cha-cys Family 13 17 Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96 Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36 Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47 Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5 Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8 Cholecystokinin receptor type A Ligand CR-1795 Family 19 41 Serine/threonine protein phosphatase PP1-alpha 1 catalytic sub... 10 0 Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 3 10 Glutamate receptor ionotropic, kainate 2 ligand (2S,3S,4S)-4-[... 14 2 NS3 and Non-structural protein 4A inhibitor (4S)-4-[[(2S)-3-ca... 1 1 Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73 Neprilysin inhibitor SureCN489232 family 3 9 Neprilysin inhibitor (2S)-2-methyl-3-oxo-3-[[(2S)-1-phenyl-3-s... 5 2 Dipeptidyl peptidase 4 inhibitor (3S)-4-[(3R)-3-amino-4-(2,4,5... 1 1 Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0 Integrin beta-3 and Integrin alpha-V inhibitor 2-[(1R,5S,11S,1... 8 2 Integrin alpha-V and Integrin beta-5 inhibitor 2-[(2S,5R,8S,11... 2 1 72 kDa type IV collagenase and Stromelysin-1 inhibitor (2S,4R)... 5 8 Integrin beta-3 and Integrin alpha-IIb inhibitor (3R,6S,12S)-6... 7 0 Neprilysin inhibitor SureCN7437961 family 2 6 Coagulation factor X inhibitor ethyl 2-[[(3S)-3-[[2-[[(2R)-2-(... 4 0 Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3R)-1-cyclohexyl-3-h... 2 0 Prothrombin inhibitor methyl (3S)-3-[[(6S,8aS)-2-benzylsulfony... 5 1 Prothrombin inhibitor [(1R)-4-carbamimidoylsulfanyl-1-[[2-[met... 1 0 Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 6 Beta-secretase 1 inhibitor 3-[[[(2S)-2-[[(3S,4S)-3-hydroxy-6-m... 2 4 Caspase-3 and Caspase-7 inhibitor valine aspartyl ketone 16 fa... 3 0 Bcl-2-like protein 1 inhibitor CHEMBL501005 family 2 2
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00295045 CHEMBL428532 Bioactive
Substance P (6-11), glutamic acid(6)- CFAMM00295040 CHEMBL66530 Bioactive
(3R,6S,12S)-6-(carboxymethyl)-12-[3-(diaminomethylideneamino)propyl]-18-naphthalen-2-yl-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentazacyclooctadecane-3-carboxylic acid CFAMM00295047 DNC012773 Investigative Drug
AcAsp-Glu-Met-Glu-Cha-Cys
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00295043 CHEMBL192913 Bioactive
(4R,7R,10R,13S)-13-[3-(diaminomethylideneamino)propanoylamino]-10-[3-(diaminomethylideneamino)propyl]-7-(naphthalen-2-ylmethyl)-6,9,12-trioxo-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxamide CFAMM00295042 CHEMBL498869 Bioactive
CHEMBL498869 CFAMM00295041 CHEMBL525454 Bioactive
CHEMBL525454 CFAMM00295046 CHEMBL451588 Bioactive
CHEMBL451588 CFAMM00295044 CHEMBL431373 Bioactive
(5R,8S,14S)-8-(carboxymethyl)-14-[3-(diaminomethylideneamino)propyl]-7,10,13,16-tetraoxo-3-thia-6,9,12,15-tetrazabicyclo[15.3.1]henicosa-1(21),17,19-triene-5-carboxylic acid CFAMM00295048 CHEMBL526537 Bioactive
CHEMBL526537
Statistics of CFAM Database
490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
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Chen Yuzong Deputy
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