CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3647
Family Name Delta-type opioid receptor and Kappa-type opioid receptor Ligand Etonitazene Family
No. of Seeds 10 No. of Other Members 46
Family Centroid CFAMM00295415 Functional Category Investigative Drug with Natural Product
Superfamily Kappa-type opioid receptor and Delta-type opioid receptor Binder Superfamily
Class Class 1456

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
SB1518 family 7 103
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) ... 9 93
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Serine/threonine-protein kinase Chk2 Inhibitor 5-nitro-2-(4-ph... 6 3
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 3 23
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Oestrogen receptor and Estrogen receptor beta Ligand 4-(2-phen... 2 9
Melanin-concentrating hormone receptor 1 Ligand ADS-103214 Family 3 4
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 4 4
Platelet-derived growth factor receptor alpha and Platelet-der... 3 18
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 7 16
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 18
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 7
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 7 13
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Cathepsin S and Cathepsin K inhibitor AGN-PC-07YOWS family 4 6
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Mitogen-activated protein kinase 14 inhibitor DEL-B, 14b family 2 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 10 54
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 7 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 9 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
DNA-(apurinic or apyrimidinic site) lyase and Nuclear receptor... 2 10
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
Translocator protein inhibitor SureCN6906757 family 3 2
Survival motor neuron protein inhibitor CHEMBL1379159 family 1 10
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 2 3
Neuropeptide Y receptor type 1 ligand 2-[(4-chlorophenoxy)meth... 5 13
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Neuropeptide Y receptor type 1 ligand 1-[3-[1-(cyclohexylmethy... 15 9
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 26 7
Melanin-concentrating hormone receptor 1 ligand SureCN3334861 ... 1 3
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Corticotropin-releasing factor receptor 1 ligand 6-ethyl-3-met... 6 10
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 15
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 7 2
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 16 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
Mu-type opioid receptor and Nitric oxide synthase, brain ligan... 3 0
Prostaglandin D2 receptor 2 ligand 2-[2-[(5-acetyl-2-methoxyph... 11 16
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
Coagulation factor X inhibitor AGN-PC-07C10A family 3 2
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 1-... 8 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Histamine H4 receptor ligand AGN-PC-00FEQJ family 2 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Melanocortin receptor 4 ligand AGN-PC-076AMT family 2 9
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Angiopoietin-1 receptor and Vascular endothelial growth factor... 2 0
Fatty acid-binding protein, adipocyte and Fatty acid-binding p... 4 4
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Collagenase 3 inhibitor 1-[6-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 2
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Gonadotropin-releasing hormone receptor ligand AGN-PC-074DFG f... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
D(2) dopamine receptor ligand SureCN11039666 family 1 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
C-C chemokine receptor type 5 ligand SureCN13543570 family 2 0
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Cathepsin S and Cathepsin K inhibitor 2-cyano-pyrropyrimidine,... 4 1
Translocator protein inhibitor AGN-PC-04X3HY family 10 1
5-hydroxytryptamine receptor 2B ligand SureCN1299002 family 2 8
Cholecystokinin receptor type A ligand SureCN3132309 family 11 0
Metabotropic glutamate receptor 2 ligand 2-[[(1R,5S)-6-[(2,5-d... 2 3
5-hydroxytryptamine receptor 1A ligand AGN-PC-04UH85 family 2 3
Nociceptin receptor and Delta-type opioid receptor ligand 2-[3... 2 1
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 2
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RCV family 2 1
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Cannabinoid receptor 2 ligand SureCN14457828 family 1 0
Oxytocin receptor ligand AGN-PC-07C71T family 3 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 3
Acyl-CoA desaturase 1 inhibitor Pyridazine, 3-[4-(2-ethylpheno... 4 2
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
Acyl-CoA:cholesterol acyltransferase inhibitor 3-(2-chloro-6-m... 4 6
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 1 1
Metabotropic glutamate receptor 5 ligand AGN-PC-0760YR family 1 0
Fatty-acid amide hydrolase 1 inhibitor bisarylimidazole deriva... 1 1
Metabotropic glutamate receptor 5 ligand 2-[4-(4-fluoro-3-meth... 1 0
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8919280 f... 23 18
Acyl-CoA:cholesterol acyltransferase inhibitor AGN-PC-00FHC0 f... 2 0
Thromboxane A2 receptor ligand SureCN9681521 family 1 0
Acyl-CoA:cholesterol acyltransferase inhibitor 1-[2-(dimethyla... 2 1
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8919926 f... 1 0
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 4 6
Coagulation factor X inhibitor AGN-PC-07C2VY family 1 0
Fatty-acid amide hydrolase 1 and Cytosolic phospholipase A2 in... 1 0
DNA-(apurinic or apyrimidinic site) lyase and Survival motor n... 1 2
Metabotropic glutamate receptor 5 ligand AGN-PC-09QKEE family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00295384 CHEMBL458142 Bioactive AGN-PC-03LKVV
CFAMM00295442 CHEMBL2046871 Bioactive 2-[(4-ethoxyphenyl)methyl]-1-[2-(1-methylpyrrolidin-2-yl)ethyl]-5-nitrobenzimidazole;hydrochloride
CFAMM00295404 CHEMBL2048416 Bioactive 2-[1-[2-(diethylamino)ethyl]-2-[(4-ethoxyphenyl)methyl]benzimidazol-5-yl]-1-nitroguanidine;hydrochloride
CFAMM00295391 CHEMBL462330 Bioactive AGN-PC-078VBB
CFAMM00295389 CHEMBL517283 Bioactive AGN-PC-078VAI
CFAMM00295421 CHEMBL462533 Bioactive AGN-PC-03LKYT
CFAMM00295415 DNC012814 Investigative Drug ETONITAZENE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27514 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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