CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3649
Family Name Genome polyprotein Inhibitor Acasp-glu-cha-val-prb-cys Family
No. of Seeds 13 No. of Other Members 18
Family Centroid CFAMM00295493 Functional Category Investigative Drug
Superfamily Genome polyprotein Inhibitor Acasp-glu-cha-val-prb-cys Superfamily
Class Class 2833

Cousin Family NamesSeedsMembers
Vasopressin V2 receptor ligand peptide analog Desmopressin family 111 1472
Trypsin inhibitor polypeptide Aprotinin Family 7 68
Oxytocin receptor Ligand Oxytocin Family 30 182
Glucan synthesis regulatory protein Inhibitor Caspofungin Family 17 71
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
Growth hormone-releasing hormone receptor ligand polypeptide ... 14 34
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Atrial natriuretic peptide receptor 1 Ligand Nesiritide Family 6 111
Bacterial outer membrane Inhibitor Polymyxin B Family 17 181
Thymopentin family 20 133
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Thymosin Beta-4 family 8 30
Plitidepsin family 15 5
Flovagatran family 12 546
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
Renin Inhibitor CP-80794 Family 16 112
Cyclophilin receptor and Cyclosporine receptor Ligand D-43787 ... 2 13
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Neuromedin-K receptor Ligand Senktide Family 15 22
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cathepsin F and Cruzipain Inhibitor Benzoyl-arginine-alanine-m... 49 348
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Cruzipain Inhibitor WRR-204 Family 18 35
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
Proto-oncogene tyrosine-protein kinase Src Inhibitor Glu-pro-g... 8 4
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-lle-agly-ile-v... 17 7
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-nal-agly-ile-v... 3 2
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Nociceptin receptor Ligand Fggftgcrkscrk Family 10 0
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Beta-secretase 1 Inhibitor Glu-leu-asp-leu-(choh-ch2)-ala-ala-... 15 11
Calcitonin gene-related peptide type 1 receptor Ligand Fvptdvg... 8 8
Caspase-1 Inhibitor Z-vad-cho Family 8 34
Cathepsin B and Cathepsin S Inhibitor Cbz-ile-leu-ala-leuvsme ... 12 14
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Mu-type opioid receptor and Nociceptin receptor Ligand Ac-ryyr... 60 11
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
Beta-secretase 1 Inhibitor KMI-172 Family 3 0
C-X-C chemokine receptor type 4 Ligand Cyclo(-d-tyr-l-ala-l-ar... 25 23
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Disks large homolog 4 Inhibitor N-(3,4-difluorophenyl)propyl-e... 3 0
Prothrombin Inhibitor Cyclotheonamide E5 Family 3 0
Integrin alpha-V Inhibitor C[rgdf-(3s)-carboxymorpholine] Family 10 2
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 8
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Sodium-dependent dopamine transporter Inhibitor Bip-tyr-thr-pr... 8 2
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Serine/threonine protein phosphatase PP1-alpha 1 catalytic sub... 10 0
Gamma-secretase subunit APH-1B and Presenilin-1 Inhibitor 3114... 8 9
Vasopressin V1a receptor Ligand Vasopressin Analogue Family 4 3
Caspase-3 and Caspase-1 inhibitor (4S)-5-[[(2S)-1-[[(3S)-2-hyd... 1 2
Renin inhibitor (2S,4S,5S)-N-butyl-6-cyclohexyl-4-hydroxy-5-[[... 12 1
Renin inhibitor (2S,4S,5S)-N-(4-aminobutyl)-6-cyclohexyl-4-hyd... 32 2
Renin inhibitor benzyl N-[3-[[(2S,4S,5S)-6-cyclohexyl-4-hydrox... 2 0
Pol polyprotein inhibitor (2S)-2-[[2-(2,5-dioxoimidazolidin-4-... 2 0
Pol polyprotein inhibitor 180968-31-4 family 8 13
Pol polyprotein inhibitor benzyl N-[(2S,3R)-1-[[(2S,3R,4R)-4-(... 5 26
Cathepsin D and Beta-secretase 1 inhibitor tert-butyl N-[(2S)-... 1 0
Cathepsin K inhibitor (4-phenylphenyl) (3S)-3-[[(3S)-1,2-dioxo... 4 10
Beta-secretase 1 and Cathepsin D inhibitor (1R,3S)-N-[(2S,3S)-... 2 25
Cathepsin S inhibitor ethyl 2-[[3-[[(2S)-3-cyclohexyl-2-[(1-me... 3 8
Cathepsin K inhibitor [(3S)-4,4-dimethyl-2-oxo-1-(2-phenylethy... 7 9
Cathepsin S inhibitor SureCN6857538 family 2 12
Cathepsin S inhibitor ethyl 2-[[3-[[(2S)-3-cyclohexyl-2-[(4-me... 2 9
Substance-P receptor ligand (1S,2R,5aS,7S,8aR,8bS)-7-amino-2-[... 12 2
Prolyl endopeptidase and Chymotrypsin-like elastase family mem... 3 9
Pol polyprotein inhibitor benzyl N-[(2S)-1-[[(2S,3S,4R,5S)-3,4... 21 5
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 2 2
Renin and Cathepsin D inhibitor (2S)-N-[(2S,3R,4S)-1-cyclohexy... 13 2
Pol polyprotein inhibitor (2S)-4-benzyl-1-[(2S,4R)-4-benzyl-2-... 10 4
Neprilysin and Aminopeptidase N inhibitor benzyl 2-[[(2S)-2-[[... 1 1
Renin inhibitor tert-butyl N-[1-[[(3S,6S,7R)-6-(cyclohexylmeth... 14 1
Angiotensin-converting enzyme inhibitor (2R)-1-[4-carboxy-4-(p... 3 3
Growth hormone secretagogue receptor type 1 ligand SureCN63170... 1 1
Caspase-1 inhibitor (3S)-5-(3,3-diphenylpropanoyloxy)-3-[[(2S)... 3 6
Caspase-1 inhibitor (3S)-5-[[(3aS,7aS)-2-oxo-3a,4,5,6,7,7a-hex... 3 0
Cathepsin B and Calpain-1 catalytic subunit inhibitor AGN-PC-0... 2 0
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Cathepsin B and Calpain-2 catalytic subunit inhibitor AGN-PC-0... 2 2
Cathepsin B and Calpain-1 catalytic subunit inhibitor AGN-PC-0... 3 1
Renin and Cathepsin D inhibitor (3S)-4-[[6-acetamido-2-[[3-nap... 6 26
Pol polyprotein inhibitor AC1LA6RA family 4 12
Cathepsin S inhibitor SureCN7397817 family 9 4
Pol polyprotein inhibitor benzyl N-[(2S,3R)-4-[(3aR,6S,7aS)-6-... 3 2
Prolyl endopeptidase inhibitor benzyl (1R,2S)-2-[(2S)-2-formyl... 2 2
Neutrophil elastase inhibitor benzyl N-[(2S)-1-[(2S)-2-[[(3S)-... 4 0
Renin and Cathepsin D inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-... 3 4
Neutrophil elastase inhibitor benzyl N-[(2S)-3-methyl-1-[(2S)-... 2 0
Pol polyprotein inhibitor Sulfone deriv. 31 family 15 4
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 16 1
Pol polyprotein inhibitor AC1LADQG family 7 1
Pol polyprotein inhibitor methyl (2S)-2-[[(2S,3R)-2-[[1-[(2R,3... 1 0
Melanin-concentrating hormone receptor 1 ligand SureCN7463098 ... 1 0
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 3
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 11
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 4 6
Pol polyprotein inhibitor MDL 74538 family 11 1
Caspase-1 and Caspase-8 inhibitor benzyl (4S,7S,9Z,11aS)-7-ben... 2 0
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 4 7
Melanocyte-stimulating hormone receptor and Melanocortin recep... 3 16
Pol polyprotein inhibitor benzyl N-[(2S)-4-amino-1-[[(2S,3R)-4... 2 1
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 13 3
Proteasome subunit beta type-5 and Proteasome subunit beta typ... 1 0
Neutrophil elastase inhibitor 1-O-benzyl 4-O-ethyl (3aS,6R,6aR... 3 4
Renin inhibitor AGN-PC-076HPD family 1 0
Pol polyprotein inhibitor SDZ PRI 053 family 8 1
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 1 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-me... 4 0
Pol polyprotein inhibitor AC1NS2O6 family 3 0
Pol polyprotein inhibitor AC1L9R8I family 1 0
Protease inhibitor AC1O54RX family 2 4
Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3R)-1-cyclohexyl-3-h... 2 0
Pol polyprotein inhibitor AC1LA3C0 family 2 18
Neutrophil collagenase and Matrix metalloproteinase-9 inhibito... 1 0
Pol polyprotein inhibitor Diol-Based HIV-1 protease inhibitor ... 1 0
Pol polyprotein inhibitor AC1LACBC family 2 0
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor (2R,3R)... 1 0
C-C chemokine receptor type 5 ligand benzyl N-[1-[(4S)-4-(cycl... 1 0
Cathepsin D and Beta-secretase 1 inhibitor benzyl 3-[[(2R,3S)-... 1 0
Pol polyprotein and Pepsin A inhibitor cgp 53820 family 1 1
Ribonucleoside-diphosphate reductase large subunit and Ribonuc... 1 0
Solute carrier family 12 member 5 inhibitor AGN-PC-07ZCLM family 1 12
Tissue alpha-L-fucosidase inhibitor AGN-PC-074YKC family 1 0
Gamma-secretase subunit PEN-2 inhibitor SureCN5966881 family 1 9
Disintegrin and metalloproteinase domain-containing protein 10... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 1-... 1 0
Signal transducer and activator of transcription 3 inhibitor [... 3 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 1 0
Angiotensin-converting enzyme and Angiotensin-converting enzym... 1 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2S,4R)... 1 1
pyrrolidine-1,2-dicarboxylate NP ZINC04028685 Family 2 3
NP (3r,7r,8as)-3-benzyl-1,4-dioxooctahydropyrrolo[1,2-a]pyrazi... 2 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00295482 CHEMBL19989 Bioactive methyl 2-[[2-[[(2S)-1-[(2R,3R)-3-[[4-amino-4-oxo-2-(phenylmethoxycarbonylamino)butanoyl]amino]-2-hydroxy-4-phenylbutyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoyl]amino]-3-phenylpropanoate
CFAMM00295473 CHEMBL1790884 Bioactive methyl (2S)-2-[[(2S,3R)-2-[[1-[(2R,3S)-3-[[(2S)-4-amino-4-oxo-2-(phenylmethoxycarbonylamino)butanoyl]amino]-2-hydroxy-4-phenylbutyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoyl]amino]-3-phenylpropanoate
CFAMM00295472 CHEMBL1790886 Bioactive methyl (2S)-2-[[(2S,3R)-2-[[(2S)-1-[(2R,3S)-3-[[(2S)-4-amino-4-oxo-2-(phenylmethoxycarbonylamino)butanoyl]amino]-2-hydroxy-4-phenylbutyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoyl]amino]-3-phenylpropanoate
CFAMM00295470 CHEMBL311757 Bioactive (2S,3aS,7aS)-1-[(4R)-4-[[6-amino-2-(phenylmethoxycarbonylamino)hexanoyl]amino]-4-carboxybutanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid
CFAMM00295469 CHEMBL432156 Bioactive AC1LA4ME
CFAMM00295485 CHEMBL1794048 Bioactive methyl (2S)-2-[[(2S,3S)-2-[[(2R)-1-[(3S)-3-[[(2R)-4-amino-4-oxo-2-(phenylmethoxycarbonylamino)butanoyl]amino]-2-hydroxy-4-phenylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoyl]amino]-3-methylbutanoate
CFAMM00295478 CHEMBL1790869 Bioactive (2S)-2-[[(2S,3R)-2-[[(2S)-1-[(2R,3S)-3-[[(2S)-4-amino-4-oxo-2-(phenylmethoxycarbonylamino)butanoyl]amino]-2-hydroxy-4-phenylbutyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoyl]amino]-3-phenylpropanoic acid
CFAMM00295475 CHEMBL1790888 Bioactive methyl (2S)-2-[[(2S,3R)-2-[[1-[(2R,3S)-3-[[(2S)-4-amino-4-oxo-2-(phenylmethoxycarbonylamino)butanoyl]amino]-2-hydroxy-4-phenylbutyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoyl]amino]-3-methylbutanoate
CFAMM00295494 DNC012827 Investigative Drug AcAsp-Glu-Cha-Val-Prb-Cpg
CFAMM00295493 DNC012825 Investigative Drug AcAsp-Glu-Cha-Val-Prb-Cys

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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