CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3656
Family Name Protein farnesyltransferase subunit beta Inhibitor BMS-316810 Family
No. of Seeds 11 No. of Other Members 18
Family Centroid CFAMM00295681 Functional Category Investigative Drug
Superfamily Farnesyltransferase beta subunit, putative Inhibitor BMS214662 Superfamily
Class Class 853

Cousin Family NamesSeedsMembers
Farnesyltransferase beta subunit, putative Inhibitor BMS214662... 11 65
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 9
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
PF-4217903 family 14 65
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Aromatase and Thromboxane-A synthase Inhibitor 6-(1h-imidazol-... 3 8
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 2-(4-... 8 25
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
Farnesyltransferase beta subunit, putative and Protein farnesy... 12 4
Motilin receptor and Growth hormone secretagogue receptor type... 2 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 4
Platelet-activating factor receptor ligand AGN-PC-0750SP family 4 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 1 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Coagulation factor X and Trypsin-1 inhibitor 1-(3-carbamimidoy... 4 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-difluo... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 1
Protein farnesyltransferase alpha subunit and Protein farnesyl... 5 0
Protein farnesyltransferase alpha subunit and Protein farnesyl... 2 0
High affinity nerve growth factor receptor ligand N-[3-amino-5... 4 10
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Dipeptidyl peptidase 4 inhibitor 7-(aminomethyl)-6-(2-chloroph... 2 5
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Protein farnesyltransferase subunit beta and Protein farnesylt... 1 0
5-hydroxytryptamine receptor 6 ligand 8-(1-pyrrolidin-3-ylpyrr... 1 0
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-a]pyridine der... 4 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00295660 CHEMBL191843 Bioactive AGN-PC-006X1J
CFAMM00295683 CHEMBL182888 Bioactive N-benzyl-N-[6-cyano-1-[(3-methylimidazol-4-yl)methyl]-3,4-dihydro-2H-quinolin-3-yl]-1-methylimidazole-4-sulfonamide
CFAMM00295666 CHEMBL181102 Bioactive AGN-PC-007LNT
CFAMM00295674 CHEMBL180307 Bioactive AGN-PC-075DNN
CFAMM00295661 CHEMBL183481 Bioactive AGN-PC-075DMX
CFAMM00295671 DNC012882 Investigative Drug PB-27
CFAMM00295681 DNC012861 Investigative Drug BMS-316810

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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