CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3660
Family Name Farnesyltransferase beta subunit, putative and Protein farnesyltransferase subunit beta Inhibitor PB-80 Family
No. of Seeds 12 No. of Other Members 4
Family Centroid CFAMM00295713 Functional Category Investigative Drug
Superfamily Farnesyltransferase beta subunit, putative Inhibitor BMS214662 Superfamily
Class Class 853

Cousin Family NamesSeedsMembers
Dihydropterin pyrophosphokinase-dihydropteroate synthase inhib... 5 60
Mast/stem cell growth factor receptor Kit and Vascular endothe... 6 34
Farnesyltransferase beta subunit, putative Inhibitor BMS214662... 11 65
Farnesyltransferase beta subunit, putative and Protein farnesy... 20 81
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 2-(4-... 8 25
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
Protein farnesyltransferase subunit beta Inhibitor BMS-316810 ... 11 18
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Motilin receptor and Growth hormone secretagogue receptor type... 2 2
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 1 7
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 4
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 28 9
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 1 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 1
Coagulation factor X and Trypsin-1 inhibitor 1-(3-carbamimidoy... 4 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 9 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-difluo... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Protein farnesyltransferase alpha subunit and Protein farnesyl... 5 0
Protein farnesyltransferase alpha subunit and Protein farnesyl... 2 0
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 10 0
Cannabinoid receptor 2 ligand 4-[[2-tert-butyl-1-(cyclohexylme... 2 0
Dipeptidyl peptidase 4 inhibitor 7-(aminomethyl)-6-(2-chloroph... 2 5
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-a]pyridine der... 4 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 1
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 3
Focal adhesion kinase 1 and Protein-tyrosine kinase 2-beta inh... 1 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 2 1
A disintegrin and metalloproteinase with thrombospondin motifs... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00295709 CHEMBL192898 Bioactive AGN-PC-00A4QL
CFAMM00295715 CHEMBL194447 Bioactive AGN-PC-006G8L
CFAMM00295707 CHEMBL362816 Bioactive AGN-PC-01LWEX
CFAMM00295705 CHEMBL183544 Bioactive AGN-PC-075DMY
CFAMM00295720 CHEMBL179598 Bioactive AGN-PC-04X40X
CFAMM00295711 CHEMBL183804 Bioactive AGN-PC-075DO7
CFAMM00295713 DNC012879 Investigative Drug PB-80
CFAMM00295712 DNC012878 Investigative Drug BMS-404683
CFAMM00295719 DNC012880 Investigative Drug PB-81

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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