CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3664
Family Name Tubulin beta chain Inhibitor Colchinol Family
No. of Seeds 3 No. of Other Members 109
Family Centroid CFAMM00295734 Functional Category Investigative Drug with Natural Product
Superfamily Acetylcholinesterase Inhibitor Galantamine Superfamily
Class Class 332

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Beta adrenergic receptor ligand catecholamine group Isoprotere... 7 130
Delta-type opioid receptor ligand opiate analog Codeine Family 15 184
u-type opioid receptor ligand opiate analog Buprenorphine Family 78 234
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Nicotinic acetylcholine receptor alpha subunit Ligand benzylis... 4 18
D(1A) dopamine receptor Ligand Fenoldopam Family 4 78
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Neuronal acetylcholine receptor subunit alpha-2 Ligand Metocur... 18 169
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Tubulin Inhibitor Colchicine Family 4 160
Zucapsacin family 7 177
Glaziovine family 1 4
D(3) dopamine receptor Ligand U-99194A Family 7 33
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Kappa-type opioid receptor Ligand Fedotozine Family 1 11
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Peptide deformylase, mitochondrial Inhibitor Tylophorinidine F... 7 1
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
5-hydroxytryptamine receptor 2A Ligand Phenethylamine Family 3 25
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 24
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
D(2) dopamine receptor and D(1A) dopamine receptor Ligand 3-br... 2 1
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 1 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Cytochrome P450 3A4 Inhibitor 1,2-diacetoxylycorine Family 4 19
Aromatase Inhibitor 2,3-dimethoxy-4'-amino-trans-stilbene Family 5 12
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 2 6
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 4
D(2) dopamine receptor and Sodium-dependent dopamine transport... 6 10
D(2) dopamine receptor and D(1A) dopamine receptor Ligand 3-ch... 2 0
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
D(2) dopamine receptor Ligand (s)-secoantioquine Family 1 10
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Kappa-type opioid receptor Ligand Morphinan Cyclic Imine Analo... 20 0
5-hydroxytryptamine receptor 1A ligand SureCN7035190 family 10 17
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 7 0
D(1A) dopamine receptor ligand DOXANTHINE family 3 0
D(1A) dopamine receptor and D(3) dopamine receptor ligand N,N-... 3 1
Transient receptor potential cation channel subfamily V member... 14 7
Sigma non-opioid intracellular receptor 1 ligand BAS 04057753 ... 5 8
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Melanin-concentrating hormone receptor 1 ligand 6-methoxy-4-[[... 2 15
Carbonic anhydrase 7 and Carbonic anhydrase 14 inhibitor 4-(6-... 7 8
7-dehydrocholesterol reductase inhibitor 2-[2-(4-chlorophenyl)... 2 3
Dipeptidyl peptidase 4 inhibitor SureCN8267584 family 1 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Transient receptor potential cation channel subfamily V member... 4 40
Putative Bioactive 5-hexyl-2-[4-[(4-methylpiperazin-1-yl)methy... 2 0
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 2 26
Endothelin-1 receptor ligand 2-[(1R,3S)-1-(1,3-benzodioxol-5-y... 3 10
Substance-P receptor ligand (5S,10S)-5-(4-fluorophenyl)-10-(2-... 3 2
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 11
Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5
Potassium voltage-gated channel subfamily H member 2 ligand 1-... 2 1
Nuclear receptor ROR-gamma ligand 3-(1,3-benzodioxol-5-yl)-1-(... 3 36
Alpha-2A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 5 3
Benzazepines Metabolite N-Methylporphyroxine Family 1 2
Putative NP ZINC12858318 Family 42 0
Putative NP ZINC12660125 Family 8 0
7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline NP ZINC33345333... 21 3
NP (z)-n-((4-(3,4-dimethoxyphenyl)tetrahydro-2h-pyran-4-yl)met... 3 2
Putative NP ZINC01322649 Family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00295826 CHEMBL2057455 Bioactive (13aS)-3,9,11-trimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-2-ol
CFAMM00295734 DNC012909 Investigative Drug COLCHINOL

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27036 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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