CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3686
Family Name Amine oxidase [flavin-containing] A Inhibitor 3-benzyl-n-(2-morpholinoethyl)quinoxalin-2-amine Family
No. of Seeds 2 No. of Other Members 3
Family Centroid CFAMM00296125 Functional Category Investigative Drug
Superfamily Amine oxidase [flavin-containing] A Inhibitor 3-benzyl-n-(2-morpholinoethyl)quinoxalin-2-amine Superfamily
Class Class 2845

Cousin Family NamesSeedsMembers
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
Histamine H1 receptor Ligand Emedastine Family 5 115
Histamine H1 receptor Ligand Mizolastine Family 14 603
Transient receptor potential cation channel subfamily V member... 15 457
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Serine/threonine-protein kinase mTOR Inhibitor AZD2014 Family 2 41
GDC-0349 family 44 77
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 37 10
JAK Inhibitor Momelotinib Family 33 83
PF-4217903 family 14 65
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Tryptase Inhibitor Babim Family 12 90
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Adenosine receptor A1 and Adenosine receptor A2a Ligand 3-benz... 1 6
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 9 24
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Urotensin-2 receptor Ligand Palosuran Family 4 4
Sodium-dependent serotonin transporter Inhibitor 6-nitroquipaz... 18 21
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Amine oxidase [flavin-containing] A Inhibitor 1-(3-(4-chlorobe... 3 12
5-hydroxytryptamine receptor 3A and D(2) dopamine receptor Lig... 1 0
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 25 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN5... 6 24
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Cathepsin K and Potassium voltage-gated channel subfamily H me... 3 1
Glucosylceramidase and Alpha-galactosidase A inhibitor AC1NNEG... 4 5
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Nociceptin receptor and Kappa-type opioid receptor ligand 1-[1... 4 4
Survival motor neuron protein inhibitor CHEMBL1581561 family 1 3
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 5 2
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
C-C chemokine receptor type 5 ligand methyl N-cyano-4-[2-[(1R,... 8 8
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 3
Histamine H1 receptor and Potassium voltage-gated channel subf... 1 2
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Mitogen-activated protein kinase kinase kinase 8 and Dual spec... 1 0
Transient receptor potential cation channel subfamily V member... 4 0
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
Smoothened homolog inhibitor N-[4-chloro-3-(5-phenyl-1H-imidaz... 4 1
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Nitric oxide synthase, inducible inhibitor SureCN2258300 family 2 24
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[[7-(t... 3 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 0
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 4 0
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 3 0
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Serine/threonine-protein kinase B-raf inhibitor imidazole-base... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 4 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 3 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Cytochrome P450 1A2 inhibitor AGN-PC-0BTGP4 family 1 0
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 1 0
Substance-P receptor ligand 2-[1-ethyl-2-[(E,3Z)-3-(1,3,3-trim... 2 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00296126 DNC012989 Investigative Drug 2-(3-benzylquinoxalin-2-ylamino)ethanol
CFAMM00296125 DNC012985 Investigative Drug 3-benzyl-N-(2-morpholinoethyl)quinoxalin-2-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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