CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3688
Family Name Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-aminobutyric acid receptor subunit beta-2 Ligand 3-butylaminocarbonyl-6-ethyl-4-quinolone Family
No. of Seeds 15 No. of Other Members 129
Family Centroid CFAMM00296314 Functional Category Investigative Drug with Natural Product
Superfamily Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-aminobutyric acid receptor subunit beta-2 Ligand 3-butylaminocarbonyl-6-ethyl-4-quinolone Superfamily
Class Class 1266

Cousin Family NamesSeedsMembers
5-alpha reductase inhibitor azasteroid derivative Dutasteride ... 36 124
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Voltage-gated sodium channel Ligand Oxcarbazepine Family 1 4
Cholesterol side-chain cleavage enzyme, mitochondrial and Arom... 9 26
Tumor necrosis factor Inhibitor Thalidomide Family 3 50
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
Histone deacetylase 1 Inhibitor Vorinostat Family 26 138
Serum albumin Inhibitor Ebselen Family 3 62
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Motilin receptor Ligand GSK962040 Family 30 457
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Dual specificity mitogen-activated protein kinase kinase Inhib... 8 4
K-604 family 4 71
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Pan-DAC Inhibitor AR-42 Family 21 153
Amonafide family 3 35
Intedanib family 7 54
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Delta-type opioid receptor Ligand Sb 227122 Family 7 5
C-C chemokine receptor type 5 Ligand Tak-220 Family 8 56
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
5-hydroxytryptamine receptor 4 Ligand TD-5108 Family 21 24
Glutamate receptor ionotropic, NMDA 1 Ligand Dcka, 5,7-dichlor... 2 7
Fumarate reductase flavoprotein subunit Inhibitor 2-heptyl-4-h... 3 16
Urokinase-type plasminogen activator Inhibitor 6-(n-phenylcarb... 2 11
Liver carboxylesterase 1 Inhibitor 1-methyl-1h-indole-2,3-dion... 10 35
Epidermal growth factor receptor Ligand 5,6-bis-p-tolylamino-i... 2 2
Potassium voltage-gated channel subfamily A member 5 Ligand N-... 8 32
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 4-methyl-5,6... 3 12
Integrin beta-3 Inhibitor L-767679 Family 3 6
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Cruzipain Inhibitor 5-chloro-1-(4-chloro-benzyl)-1h-indole-2,3... 3 13
Integrin beta-3 Inhibitor SB-208651 Family 9 28
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
Extracellular calcium-sensing receptor Ligand 3-phenethyl-2-ph... 3 137
MO15-related protein kinase Pfmrk Inhibitor 5-nitro-1h-indole-... 1 4
Transient receptor potential cation channel subfamily V member... 6 33
Poly [ADP-ribose] polymerase 1 Inhibitor 3-morpholin-4-ylmethy... 1 2
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 13
Acetylcholinesterase Inhibitor Bw-28c51 Family 3 8
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 1 9
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
Aurora kinase B Inhibitor Hesperadin Family 1 1
Integrin alpha-2 and Integrin beta-3 Inhibitor 3-(3-(carbamoyl... 7 13
Liver carboxylesterase 1 Inhibitor 6-bromo-5-methyl-1h-indole-... 1 0
Liver carboxylesterase 1 Inhibitor 7-chloro-1h-indole-2,3-dion... 6 5
Liver carboxylesterase 1 Inhibitor 7-(trifluoromethyl)-1h-indo... 1 1
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 7 35
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 13
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Oxysterols receptor LXR-alpha Ligand 2-(2-phenethylphenyl)isoi... 4 7
Transient receptor potential cation channel subfamily V member... 1 5
Progesterone receptor Ligand 3-(3,3-dimethyl-2-oxoindolin-5-yl... 2 10
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Telomerase reverse transcriptase Inhibitor 2,7-bis[2-(piperidi... 6 8
Poly [ADP-ribose] polymerase 1 Inhibitor 5-aminoisoquinolin-1(... 2 8
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 12
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Muscarinic acetylcholine receptor M5 Ligand VU0119498 Family 1 3
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 2 17
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 7
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 I... 9 7
D(2) dopamine receptor Ligand PD-168077 Family 6 5
Aldose reductase Inhibitor (4-methyl-2-oxo-2h-quinolin-1-yl)-a... 1 15
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(3-cyanophe... 7 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
D(4) dopamine receptor ligand AGN-PC-074VC9 family 2 3
Vasopressin V1a receptor ligand AGN-PC-074VJP family 3 1
Acetylcholinesterase inhibitor AGN-PC-07ZFTY family 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEDE family 7 17
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZFJZ family 1 3
Vasopressin V1a receptor ligand AGN-PC-074VSA family 3 0
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 4 8
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 5 13
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 1-eth... 7 3
Cathepsin K and Cathepsin B inhibitor AGN-PC-01Z23J family 2 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 7 5
C-C chemokine receptor type 3 ligand 4-[(3-acetylphenyl)carbam... 3 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 4
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
C-C chemokine receptor type 3 ligand SureCN6703027 family 2 1
Acetylcholinesterase inhibitor CHEMBL1651130 family 2 3
Vasopressin V2 receptor ligand [2-chloro-4-(prop-2-enylamino)p... 3 14
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 10 0
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 53
Sigma non-opioid intracellular receptor 1 ligand 2-(2-nitrophe... 2 5
Hypoxia-inducible factor 1-alpha and Ubiquitin carboxyl-termin... 1 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
Cellular tumor antigen p53 and Inositol monophosphatase 1 inhi... 1 12
Cellular tumor antigen p53 inhibitor CHEMBL1554992 family 1 0
Peptide deformylase inhibitor (2R)-2-[[formyl(hydroxy)amino]me... 2 1
Peptide deformylase inhibitor (2R)-2-(cyclopentylmethyl)-3-[fo... 11 2
Prelamin-A/C and Lysine-specific demethylase 4E inhibitor 4-(4... 2 3
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 16 6
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 8 1
Cannabinoid receptor 2 ligand AGN-PC-087MPO family 7 21
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Amyloid beta A4 protein inhibitor AGN-PC-08WTQK family 1 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 6
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 3
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 2 4
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Mitogen-activated protein kinase 14 inhibitor 4-chloro-N-cyclo... 2 0
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 1 0
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 3 5
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... 1 8
Follicle-stimulating hormone receptor ligand AGN-PC-005HER family 5 2
C-C chemokine receptor type 3 and Sodium-dependent serotonin t... 12 2
Delta-type opioid receptor and Potassium voltage-gated channel... 3 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Histamine H3 receptor ligand SureCN3058680 family 4 0
Transient receptor potential cation channel subfamily V member... 1 1
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
C-C chemokine receptor type 2 ligand N-[2-[[(2S,3S)-1-[(2,4-di... 13 8
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 19
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-cyc... 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-cyc... 1 2
Testosterone 17-beta-dehydrogenase 3 inhibitor SureCN4802053 f... 2 2
Bifunctional epoxide hydrolase 2 inhibitor 1-(3-acetylphenyl)-... 1 3
Sphingosine 1-phosphate receptor 1 ligand 7-(2-hydroxyethyl)-1... 2 10
D(2) dopamine receptor and Potassium voltage-gated channel sub... 1 1
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 1-eth... 8 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 6-ter... 2 7
Cannabinoid receptor 2 ligand AGN-PC-00SRU8 family 1 3
C-C chemokine receptor type 3 ligand 1-(3-acetylphenyl)-3-[3-[... 9 1
P2X purinoceptor 7 inhibitor 2-[3-fluoro-4-(trifluoromethyl)ph... 3 0
Phospholipase D1 and Phospholipase D2 inhibitor 4-bromo-N-[(2S... 1 2
Cannabinoid receptor 2 ligand AGN-PC-046LZ0 family 1 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 7 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(3... 2 4
Coagulation factor X inhibitor N-(4-chlorophenyl)-2-[[4-(2-oxo... 2 0
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 1 1
C-C chemokine receptor type 2 ligand AGN-PC-03L0X5 family 13 0
Chitin synthase 1 inhibitor AC1O53V7 family 9 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 2
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 4 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 1
Protease and Replicase polyprotein 1a inhibitor AC1LALLS family 1 0
C-C chemokine receptor type 3 ligand AGN-PC-075BAT family 1 0
Sodium-dependent noradrenaline transporter inhibitor AGN-PC-07... 1 1
Vascular endothelial growth factor receptor 2 ligand isoindoli... 1 0
Histone deacetylase 6 and Histone deacetylase 2 inhibitor 4-[[... 2 1
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 1 2
Vascular endothelial growth factor receptor 2 ligand SureCN578... 1 2
Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family 2 1
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZK family 3 0
5-hydroxytryptamine receptor 4 ligand 2-oxo-N-[(1R,5S)-8-(2-pi... 13 5
D(1A) dopamine receptor and D(3) dopamine receptor ligand 1-[4... 1 0
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-[2-(1-hydroxy-3... 3 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 3
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Vasopressin V2 receptor and Vasopressin V1a receptor ligand (2... 4 0
C-C chemokine receptor type 5 ligand AC1MHP8Y family 1 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1
Tyrosine-protein kinase ITK/TSK and Mast/stem cell growth fact... 1 0
Glucose-dependent insulinotropic receptor ligand AGN-PC-04UO8L... 2 2
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... 7 11
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 1 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Aldose reductase inhibitor (4R)-6-fluoro-3-methylspiro[1H-quin... 4 16
Protein farnesyltransferase subunit beta and Protein farnesylt... 4 13
Progesterone receptor ligand AGN-PC-048NI9 family 1 5
Histone deacetylase 6 and Histone deacetylase 1 inhibitor AGN-... 1 2
Serine/threonine-protein kinase Chk1 inhibitor 6-oxo-9-(2-oxo-... 1 0
Multidrug resistance protein 1 inhibitor AGN-PC-07R6HU family 1 0
Telomerase reverse transcriptase inhibitor AGN-PC-07ZBGW family 2 0
Cytochrome P450 2C19 and 3-hydroxyacyl-CoA dehydrogenase type-... 1 5
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 1 1
Beta-secretase 1 inhibitor 3-(2-Amino-6-Benzoylquinazolin-3(4h... 1 0
NP Methyl 2-(5,11-dioxo-2,3,11,11a-tetrahydro-1h-benzo[e]pyrro... 2 1
1,3,3a,5-tetrahydro-[1,3]thiazolo[4,3-c][1,4]benzodiazepine-4,... 3 1
4,4,6,9-tetramethyl-6-phenyl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]q... 5 1
NP (s)-methyl 2-(3-(2,5-dioxo-2,3,4,5-tetrahydro-1h-benzo[e][1... 11 3
6-methyl-3-[(6-methyl-2-oxido-4-oxo-1H-quinolin-3-yl)methyl]-4... 1 1
3-prop-2-enyl-1H-quinolin-4-one NP 6-amino-2-methylquinolin-4-... 5 3
1H-quinolin-4-one NP 4-(6-bromo-4-hydroxy-2-methylquinolin-3-y... 2 0
Putative NP ZINC32124058 Family 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00296174 CHEMBL1215964 Bioactive AGN-PC-080WMI
CFAMM00296284 CHEMBL1215888 Bioactive AGN-PC-080WFB
CFAMM00296225 CHEMBL1215919 Bioactive AGN-PC-080W34
CFAMM00296195 CHEMBL502276 Bioactive N-(1-adamantyl)-4-oxo-1-pentyl-6-propan-2-ylquinoline-3-carboxamide
CFAMM00296291 CHEMBL322378 Bioactive 2-[(9aR)-2,3,4,6,7,8,9,9a-octahydro-1H-quinolizin-1-yl]-N-(4-benzoyl-2-methylphenyl)acetamide
CFAMM00296158 CHEMBL523577 Bioactive N-(1-adamantyl)-4-oxo-1-pentyl-6-phenylquinoline-3-carboxamide
CFAMM00296202 CHEMBL158252 Bioactive AGN-PC-003YT6
CFAMM00296263 CHEMBL201571 Bioactive AGN-PC-00BLHI
CFAMM00296277 CHEMBL1668518 Bioactive AGN-PC-08YC70
CFAMM00296189 CHEMBL148689 Bioactive AC1LALLV
CFAMM00296248 CHEMBL385808 Bioactive AGN-PC-00SRU7
CFAMM00296304 DNC012990 Investigative Drug 6-benzyl-3-propylaminocarbonyl-4-quinolone
CFAMM00296315 DNC012992 Investigative Drug 6-ethyl-3-propylaminocarbonyl-4-quinolone
CFAMM00296314 DNC012991 Investigative Drug 3-butylaminocarbonyl-6-ethyl-4-quinolone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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