CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3702
Family Name Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methylpyridin-2-yl)benzamide Family
No. of Seeds 3 No. of Other Members 15
Family Centroid CFAMM00296423 Functional Category Investigative Drug with Natural Product
Superfamily Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methylpyridin-2-yl)benzamide Superfamily
Class Class 2332

Cousin Family NamesSeedsMembers
Peroxisome proliferator-activated receptor gamma Ligand Piogli... 2 29
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Histamine H1 receptor Ligand Mepyramine Family 5 65
Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... 23 121
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Sodium-dependent noradrenaline transporter Inhibitor Neri Iv F... 6 58
Smoothened homolog Inhibitor LDE225 Family 3 76
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
MK-6096 family 3 69
Glucokinase Inhibitor GKA1 Family 2 67
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) ... 9 93
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 4 4
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Reverse transcriptase Inhibitor Atevirdine Family 4 55
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
5-hydroxytryptamine receptor 1A Ligand CP-293019 Family 9 24
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
Tubulin beta chain Inhibitor 2-furan-2-yl-7-methyl-1h-[1,8]nap... 1 1
Liver carboxylesterase 1 Inhibitor SM-32504 Family 3 28
Integrin beta-3 and Integrin alpha-V inhibitor methyl (3S)-3-(... 12 13
Reverse transcriptase/RNaseH inhibitor AC1LALKM family 2 19
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 6
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 11
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 3 13
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 2 3
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Somatostatin receptor type 5 ligand AGN-PC-088VSK family 2 3
Aurora kinase A inhibitor SureCN761545 family 2 2
Aurora kinase A inhibitor SureCN761045 family 2 0
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Adenosine receptor A1 ligand SureCN5012033 family 2 9
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 4
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Reverse transcriptase/RNaseH inhibitor Dipyridodiazepinone der... 1 8
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor Sure... 14 8
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
ALK tyrosine kinase receptor and Insulin receptor ligand SureC... 7 1
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Metabotropic glutamate receptor 5 ligand AGN-PC-09QLD2 family 1 2
Metabotropic glutamate receptor 5 ligand AGN-PC-09QM67 family 1 0
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Melanin-concentrating hormone receptor 1 ligand N-[3-(2-aminoq... 4 1
5-hydroxytryptamine receptor 3A ligand 6-methyl-5-[4-[3-[(2R)-... 12 3
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Reverse transcriptase/RNaseH and Cytochrome P450 2C19 inhibito... 7 2
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Glycogen synthase kinase-3 beta inhibitor CHEMBL1940990 family 3 3
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 1... 1 0
Growth hormone secretagogue receptor type 1 and Potassium volt... 3 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Melanin-concentrating hormone receptor 1 ligand 3-[6-[3-(dimet... 14 6
Melanocortin receptor 4 ligand N-[(2R)-3-(2,4-dichlorophenyl)-... 2 2
Melanin-concentrating hormone receptor 1 ligand 3-[6-[3-(dimet... 1 13
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 3 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Collagenase 3 inhibitor 4-[4-[[5-(2-ethoxyethyl)-2,4,6-trioxo-... 3 0
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
G-protein coupled bile acid receptor 1 ligand 2-ethyl-6-[3-[4-... 4 6
Motilin receptor ligand SureCN2765637 family 1 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... 2 0
Metabotropic glutamate receptor 5 ligand AGN-PC-0DB8TJ family 2 0
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0Z0U... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Orexin receptor type 1 and Orexin receptor type 2 ligand (1R,2... 6 1
Growth hormone secretagogue receptor type 1 and Muscarinic ace... 3 9
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 2
Metabotropic glutamate receptor 5 and Cytochrome P450 3A4 liga... 3 7
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 1
Gonadotropin-releasing hormone receptor ligand AGN-PC-074DFG f... 2 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Reverse transcriptase/RNaseH inhibitor PETT deriv. 14 family 1 0
Nuclear receptor ROR-gamma and Prelamin-A/C ligand ST50133141 ... 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 5
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 5
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase inhibitor 1-... 1 3
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 6 0
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 2 2
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RCV family 2 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 0
Acyl-CoA desaturase inhibitor SureCN1182546 family 2 5
Acyl-CoA desaturase inhibitor SureCN1182719 family 1 0
Inositol monophosphatase 1 and Prelamin-A/C inhibitor GNF-Pf-3... 1 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 1 3
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 2 25
Hydroxycarboxylic acid receptor 2 and Hydroxycarboxylic acid r... 2 3
Survival motor neuron protein inhibitor CHEMBL1496852 family 1 1
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 4
Retinal dehydrogenase 1 and Nuclear receptor ROR-gamma ligand ... 1 2
Metabotropic glutamate receptor 5 ligand AGN-PC-09QJ1Q family 1 0
Dipeptidyl peptidase 4 inhibitor 7-amino-6-(aminomethyl)-5-(2-... 2 0
Thromboxane-A synthase and Platelet-activating factor receptor... 1 6
Thromboxane-A synthase and Platelet-activating factor receptor... 1 0
Fibroblast growth factor receptor 1 and Fibroblast growth fact... 2 0
Potassium-transporting ATPase subunit beta and Potassium-trans... 1 1
5-(4-methoxyphenyl)-4-oxo-1H-pyrido[2,3-d]pyrimidin-2-olate NP... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00296445 CHEMBL567950 Bioactive AGN-PC-07CPOZ
CFAMM00296423 DNC013057 Investigative Drug 3-methoxy-N-(6-methylpyridin-2-yl)benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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