CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID371
Family Name Plasmepsin-2 Inhibitor KNI-727 Family
No. of Seeds 3 No. of Other Members 37
Family Centroid CFAMM00189397 Functional Category Investigative Drug with Natural Product
Superfamily Plasmepsin-2 Inhibitor KNI-727 Superfamily
Class Class 590

Cousin Family NamesSeedsMembers
Oxytocin receptor Ligand Oxytocin Family 30 182
Penicillin binding protein Inhibitor Cefadroxil Family 5 17
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
HIV-1 protease Inhibitor Lopinavir Family 4 25
Thymopentin family 20 133
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Integrin alpha-4 Inhibitor Firategrast Family 3 93
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Vasopeptidase Inhibitor Fasidotril Family 3 7
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cruzipain Inhibitor WRR-204 Family 18 35
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Plasmepsin-2 Inhibitor KNI-10079 Family 19 8
Plasmepsin-2 Inhibitor KNI-10314 Family 6 2
Plasmepsin-2 Inhibitor KNI-10283 Family 24 0
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
Plasmepsin-2 Inhibitor KNI-10074 Family 1 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Glutamate receptor ionotropic, kainate 2 ligand (2S,3S,4S)-4-[... 4 10
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Neprilysin inhibitor SureCN389939 family 5 6
Caspase-3 and Caspase-7 inhibitor SureCN14113084 family 2 6
Caspase-3 and Caspase-7 inhibitor valine aspartyl ketone 31 fa... 1 8
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[4-(ben... 12 20
Dipeptidyl peptidase 4 and Seprase inhibitor (2R)-2-[4-[[[(2S)... 17 19
Integrin beta-1 and Integrin alpha-4 inhibitor AGN-PC-074GDW f... 9 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-ethy... 7 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(3-benz... 7 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[1-(ben... 6 5
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(4S)-3... 3 24
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6453971 f... 3 4
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 16 23
Caspase-3 and Caspase-7 inhibitor (3S)-5-benzylsulfanyl-3-[[(2... 1 2
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-5-(diami... 2 0
Angiotensin-converting enzyme 2 and Neprilysin inhibitor (2S)-... 6 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2R)-3-[4-(2-me... 18 1
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN5686827 f... 7 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-me... 4 0
Pol polyprotein inhibitor N-[2-Hydroxy-2-(8-Isopropyl-6,9-Diox... 7 6
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6429531 f... 2 0
72 kDa type IV collagenase and Collagenase 3 inhibitor SureCN7... 5 2
Neprilysin inhibitor benzyl (2S)-3-(4-hydroxyphenyl)-2-[[2-(su... 1 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 9
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 2 1
Angiotensin-converting enzyme inhibitor (2S,4S)-1-[(2S)-2-meth... 1 0
Beta-lactamase and Histone-lysine N-methyltransferase 2A inhib... 1 7
(2S)-2-[(2-methoxyphenyl)methylcarbamoylamino]-4-methylsulfany... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00189352 CHEMBL282998 Bioactive (2S)-2-[[(4R)-3-acetyl-1,3-thiazolidine-4-carbonyl]amino]-3-[4-(2-methoxyphenyl)phenyl]propanoic acid
CFAMM00189365 CHEMBL282637 Bioactive (2S)-2-[[(4S)-3-acetyl-1,3-thiazolidine-4-carbonyl]amino]-3-[4-(2-methoxyphenyl)phenyl]propanoic acid
CFAMM00189397 DNC000836 Investigative Drug KNI-727

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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