CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3722
Family Name Delta-type opioid receptor and Kappa-type opioid receptor Ligand Dmt-pro-emp-phe-nh2 Family
No. of Seeds 48 No. of Other Members 10
Family Centroid CFAMM00296634 Functional Category Investigative Drug
Superfamily Mu-type opioid receptor Ligand Alvimopan Superfamily
Class Class 323

Cousin Family NamesSeedsMembers
Vasopressin V2 receptor ligand peptide analog Desmopressin family 111 1472
Alpha-1 adrenergic receptor ligand arylethanolamine derivative... 4 37
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Trypsin inhibitor polypeptide Aprotinin Family 7 68
Opioid receptor ligand opiate Levorphanol Family 18 537
Oxytocin receptor Ligand Oxytocin Family 30 182
Tyrosine 3-monooxygenase Inhibitor L-tyrosine Family 4 36
Glucan synthesis regulatory protein Inhibitor Caspofungin Family 17 71
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Growth hormone-releasing hormone receptor ligand polypeptide ... 14 34
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Zucapsacin family 7 177
Thymopentin family 20 133
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Plitidepsin family 15 5
Flovagatran family 12 546
Tryptase Inhibitor APC-366 Family 2 12
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 20 35
Caspase-1 Inhibitor Yvad Family 1 0
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU84687 F... 2 14
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Proto-oncogene tyrosine-protein kinase Src Inhibitor Glu-pro-g... 8 4
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Proto-oncogene tyrosine-protein kinase Src Inhibitor Y-c[d-pen... 20 66
Somatostatin receptor type 1 Ligand Des-aa1,2,5-[(nalphame)lys... 16 11
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 4-hy... 2 13
Estradiol 17-beta-dehydrogenase 1 Inhibitor N-n-diethyl Estrad... 6 16
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Estradiol 17-beta-dehydrogenase 1 Inhibitor N-ethyl Estrone-16... 3 5
Estradiol 17-beta-dehydrogenase 1 Inhibitor N-isopropyl Estrad... 3 0
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 9 43
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 23 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 36 15
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 31 5
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Mu-type opioid receptor and Nociceptin receptor Ligand Ac-ryyr... 60 11
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
C-X-C chemokine receptor type 4 Ligand Cyclo(-d-tyr-l-ala-l-ar... 25 23
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Prothrombin Inhibitor Cyclotheonamide E5 Family 3 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 8
Genome polyprotein Inhibitor Acasp-glu-cha-val-prb-cys Family 13 18
Genome polyprotein Inhibitor Acasp-glu-dif-ile-cha-cys-iqc-nle... 9 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 3 0
Sodium-dependent dopamine transporter Inhibitor Bip-tyr-thr-pr... 8 2
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 4
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 4
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Vasopressin V1a receptor Ligand Vasopressin Analogue Family 4 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 9
Interstitial collagenase and Low affinity immunoglobulin epsil... 1 1
Neprilysin and Aminopeptidase N inhibitor (2S)-2-[[(2S)-2-[[[a... 13 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 3 0
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Cathepsin B and Calpain-2 catalytic subunit inhibitor AGN-PC-0... 2 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 2
Peptide deformylase inhibitor (2R)-2-(cyclopentylmethyl)-3-[fo... 2 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Pol polyprotein inhibitor CHEMBL305466 family 4 7
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Muscarinic acetylcholine receptor M3 and Beta-2 adrenergic rec... 5 0
Plasminogen inhibitor (2S)-2-acetamido-5-(diaminomethylideneam... 1 0
Somatostatin receptor type 1 and Somatostatin receptor type 4 ... 2 0
Histone deacetylase 1 and Histone deacetylase 6 inhibitor (2E)... 1 0
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 2 1
Melanocyte-stimulating hormone receptor and Melanocortin recep... 3 16
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
KiSS-1 receptor ligand (2S)-N-[(2S)-1-[[(2S)-4-amino-1-[[(2S)-... 1 0
Mu-type opioid receptor ligand 4-[(2S)-3-[[(2S)-1-(4-hydroxyph... 2 6
Delta-type opioid receptor ligand N-[(7S)-5-(3-hydroxyphenyl)-... 9 3
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 6 2
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 2 8
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Vasopressin V1a receptor and Vasopressin V1b receptor ligand C... 6 0
C-X-C chemokine receptor type 4 ligand CHEMBL2372990 family 3 0
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4R)-4-(3-hydroxyp... 4 1
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 3
Pol polyprotein inhibitor AC1LA3AI family 5 9
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
Neprilysin inhibitor benzyl (2S)-3-(4-hydroxyphenyl)-2-[[2-(su... 1 1
Prostaglandin E2 receptor EP4 subtype and Prostaglandin E2 rec... 2 1
Neutrophil collagenase and Collagenase 3 inhibitor [4-(4-chlor... 2 0
Prothrombin inhibitor (2S)-1-[(2R)-2-amino-2-cyclohexylacetyl]... 2 1
Pol polyprotein inhibitor (2R)-5-[(3S,5R)-3,5-dibenzyl-2-oxopy... 3 0
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 1 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 3 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Gonadotropin-releasing hormone receptor ligand (3R,6S,12S,15S,... 1 0
Neuropeptide Y receptor type 1 ligand (2R)-5-[[amino-[[2-[2-[2... 1 0
Somatostatin receptor type 2 and Somatostatin receptor type 3 ... 2 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 2
Kappa-type opioid receptor ligand N-[(1S)-2-[(3S)-3-hydroxypyr... 2 0
C-C chemokine receptor type 3 and Probable C-C chemokine recep... 5 2
Beta-lactamase inhibitor sodium;(1R,5S)-4-[2-amino-2-(4-hydrox... 1 0
Signal transducer and activator of transcription 3 inhibitor [... 7 25
Glutamate receptor ionotropic, NMDA 2B ligand AGN-PC-076B5T fa... 1 0
Genome polyprotein inhibitor (2S)-6-amino-N-[(2S)-6-amino-1-[[... 2 0
Signal transducer and activator of transcription 3 inhibitor [... 3 1
C-C chemokine receptor type 3 ligand SureCN3932025 family 1 1
N-formyl-2-(4-hydroxyphenyl)acetamide NP Agn-pc-04a0ox Family 1 1
7-[(1R,2R)-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]-N-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00296607 CHEMBL437132 Bioactive (2R,5R)-5-acetamido-N-[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1-(methylamino)-3-naphthalen-2-yl-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]-2-[(4-fluorophenyl)methyl]-6-(4-hydroxyphenyl)hexanamide
CFAMM00296598 CHEMBL192372 Bioactive (2S)-1-[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]-N-[(2S)-1-[[(2S,3S)-1-amino-1-oxo-3-phenylbutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00296605 CHEMBL152690 Bioactive (2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)-N-[(3S,6R,15R)-3-(naphthalen-2-ylmethyl)-2,5,11,14-tetraoxo-1,4,10,13-tetrazabicyclo[13.3.0]octadecan-6-yl]propanamide
CFAMM00296621 CHEMBL379054 Bioactive (2S)-2-acetamido-N-[(2R)-1-[(2S)-2-[3-(diaminomethylideneamino)propyl]-4-[(2S)-1-(methylamino)-3-naphthalen-2-yl-1-oxopropan-2-yl]-3-oxopiperazin-1-yl]-1-oxo-3-phenylpropan-2-yl]-3-(4-hydroxyphenyl)propanamide
CFAMM00296612 CHEMBL183278 Bioactive 1-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]cyclohexane-1-carboxamide
CFAMM00296604 CHEMBL502792 Bioactive (2S)-2-amino-N-[(2S)-1-[[(2S)-1-amino-3-(3-tert-butyl-4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-3-phenylpropanamide
CFAMM00296603 CHEMBL2181195 Bioactive (2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-5-(carbamoylamino)pentanoyl]amino]-3-phenylpropanoyl]-methylamino]hexanamide
CFAMM00296619 CHEMBL363851 Bioactive (1S,2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]cyclohexane-1-carboxamide
CFAMM00296632 DNC013278 Investigative Drug Tyr-Pro-Tmp-Phe-NH
CFAMM00296623 DNC013285 Investigative Drug Dmt-Pro-Mmp-Phe-NH2
CFAMM00296614 DNC013489 Investigative Drug Dmt-Sar-Phe-D-2-Nal-NH
CFAMM00296631 DNC013279 Investigative Drug Dmt-Pro-Dmt-Phe-NH2
CFAMM00296606 DNC013827 Investigative Drug antanal 2
CFAMM00296622 DNC013287 Investigative Drug Dmt-Pro-Phe-Phe-NH2
CFAMM00296636 DNC013273 Investigative Drug Dmt-Pro-Imp-Phe-NH2
CFAMM00296635 DNC013274 Investigative Drug Tyr-Pro-Imp-Phe-NH2
CFAMM00296626 DNC013157 Investigative Drug Dmt-Pro-Phe-D-1-Nal-NH2
CFAMM00296634 DNC013275 Investigative Drug Dmt-Pro-Emp-Phe-NH2
CFAMM00296610 DNC013490 Investigative Drug Tyr-Sar-Phe-D-2-Nal-NH2
CFAMM00296625 DNC013281 Investigative Drug Dmt-Pro-Dmp-Phe-NH2
CFAMM00296633 DNC013277 Investigative Drug Dmt-Pro-Tmp-Phe-NH2
CFAMM00296608 DNC013492 Investigative Drug Tyr-Pro-Phe-D-2-Nal-NH2
CFAMM00296624 DNC013283 Investigative Drug Dmt-Pro-3,5Dmp-Phe-NH2

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48712 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543