CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3729
Family Name Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hydroxymalonamide Family
No. of Seeds 9 No. of Other Members 86
Family Centroid CFAMM00296841 Functional Category Investigative Drug with Natural Product
Superfamily Aminopeptidase N Binder Superfamily
Class Class 586

Cousin Family NamesSeedsMembers
Noradrenergic re-uptake and Serotonin re-uptake inhibitor phen... 18 41
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Vasopressin V1a receptor Ligand Felypressin Family 12 820
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Sodium channel protein type 5 subunit alpha Ligand Indecainide... 2 41
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family 5 255
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Nuclear receptor subfamily 1 group I member 3 ligand piperazin... 3 82
Acetylcholinesterase Inhibitor Ambenonium Family 4 71
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
DNA Binder Procarbazine Family 8 358
Peripheral carotid chemoreceptor Ligand Doxapram Family 4 36
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Neuromedin-K receptor Ligand Osanetant Family 38 192
Motilin receptor Ligand GSK962040 Family 30 457
Substance-P receptor Ligand Orvepitant Family 11 46
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
5-hydroxytryptamine receptor 2C Ligand Lorcaserin Family 8 38
Tumor necrosis factor Inhibitor Talactoferrin Alfa Family 26 131
Substance-P receptor Ligand Vestipitant Family 14 137
Bavisant family 9 65
Zicronapine family 43 62
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Melanocortin receptor 4 Ligand Ro-27-3225 Family 6 52
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Reverse transcriptase Inhibitor 3-benzylamino-5-ethyl-6-methyl... 2 24
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
72 kDa type IV collagenase Inhibitor Batimastat Family 6 52
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Prothrombin Inhibitor D-leucyl-n-(3-chlorobenzyl)-l-prolinamid... 18 168
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU83876 F... 3 51
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor Bexlosteride... 5 23
Disintegrin and metalloproteinase domain-containing protein 17... 8 7
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 10 52
Histone deacetylase 1 Inhibitor 8-(3-benzoyl-ureido)-octanoic ... 7 13
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(6... 1 12
Bifunctional epoxide hydrolase 2 Inhibitor N-(3-chloro-phenyl)... 2 43
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Dipeptidyl peptidase 4 Inhibitor 2-(2-chlorophenyl)-2-morpholi... 2 34
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Dipeptidyl peptidase 4 Inhibitor N4-(4-chlorobenzyl)-2,4-diami... 10 22
Histamine H3 receptor Ligand N-benzyl-4-cyclopentylpiperazine-... 3 19
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Dipeptidyl peptidase 4 Inhibitor 1-benzyl-4-(2,4-dichloropheny... 2 10
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Phospholipase D1 Inhibitor Halopemide Family 17 111
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Aminopeptidase N Inhibitor N1,2-dibenzyl-n3-hydroxymalonamide ... 5 23
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Sodium-dependent serotonin transporter Inhibitor Irindalone Fa... 16 9
Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2... 8 13
Aminopeptidase N Inhibitor 2-amino-n1-benzyl-n3-hydroxymalonam... 3 4
Aminopeptidase N Inhibitor 2-benzyl-n1-hydroxy-n3-(4-phenylbut... 5 3
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 1
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3'... 14 11
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand N-(3-... 1 7
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZBI0 family 2 16
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 4 13
D(4) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 1 0
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 7 9
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 2 0
Melanocortin receptor 4 and Melanocortin receptor 5 ligand Sur... 25 14
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 1 1
C-C chemokine receptor type 5 ligand N-[(1S)-3-[(3aS,6aR)-5-(2... 1 1
72 kDa type IV collagenase and Matrilysin inhibitor (2S,3R)-N-... 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 7
Prothrombin inhibitor (2S)-N-[[2-(aminomethyl)-5-chlorophenyl]... 5 11
Melanocortin receptor 4 ligand tert-butyl 4-[(3S)-4-[4-[2-[1-[... 2 6
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Sodium-dependent dopamine transporter and Transporter inhibito... 4 3
Coagulation factor X inhibitor 3-amino-4-chloro-N-[(1R)-2-[4-(... 1 1
P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methy... 16 11
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-2-[... 14 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 6
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2,5-dichlor... 3 4
Substance-P receptor ligand AGN-PC-075NUD family 4 1
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-044L... 6 7
Substance-P receptor ligand AGN-PC-075NRR family 2 1
Pyruvate kinase PKM and Huntingtin inhibitor CHEMBL1455935 family 1 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 2
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 9 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 2 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
D(3) dopamine receptor and Alpha-1B adrenergic receptor ligand... 11 8
Prelamin-A/C and Ras-related protein Rab-9A inhibitor CHEMBL15... 1 7
Neuromedin-K receptor ligand SureCN2477089 family 2 4
Prothrombin inhibitor AGN-PC-09QJ23 family 2 5
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
Transporter and Sodium-dependent serotonin transporter inhibit... 4 8
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 0
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 7 31
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 7 16
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... 4 9
Vasopressin V1a receptor ligand (2R)-3-(4-chlorophenyl)-2-[[2-... 6 2
Vasopressin V1a receptor ligand N-[(2R)-3-(4-chlorophenyl)-1-[... 6 0
Vasopressin V1a receptor ligand N-[(2R)-3-(4-chlorophenyl)-1-(... 1 0
Dipeptidyl peptidase 8 inhibitor (2S)-2-amino-4-[4-[bis(4-fluo... 2 9
Prothrombin inhibitor SureCN6921523 family 4 1
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 6 9
Transporter and Sodium-dependent dopamine transporter inhibito... 3 42
Transporter and Sodium-dependent dopamine transporter inhibito... 6 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075C6K ... 3 22
Lysosomal Pro-X carboxypeptidase inhibitor (2S,3S)-2-[(2-amino... 3 3
Sigma non-opioid intracellular receptor 1 ligand 2-(3-bromophe... 5 1
Substance-P receptor ligand (3S,4S)-N-[[3,5-bis(trifluoromethy... 8 9
Renin and Potassium voltage-gated channel subfamily H member 2... 1 0
Renin and Potassium voltage-gated channel subfamily H member 2... 3 2
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
C-C chemokine receptor type 5 ligand AGN-PC-075XOD family 2 0
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 4 1
Substance-P receptor ligand (3R,4R)-1-(1-acetylpiperidine-4-ca... 9 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (3R... 7 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (3R... 6 1
Sodium-dependent serotonin transporter and Sodium-dependent do... 6 3
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 8 4
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 4
Melanocortin receptor 4 ligand SureCN6183720 family 2 5
C-C chemokine receptor type 2 ligand (2S)-N-[[3,5-bis(trifluor... 1 0
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Substance-P receptor ligand AGN-PC-073QYE family 6 11
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 3
C-C chemokine receptor type 2 ligand (1S,3R)-N-[[3-fluoro-5-(t... 22 27
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 4 0
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-(cyanomethyl)-... 1 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 4
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 14 5
P2X purinoceptor 7 inhibitor (2S)-N-[[2-chloro-3-(trifluoromet... 3 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 1
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
Receptor activity-modifying protein 1 and Calcitonin gene-rela... 2 4
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2-chloro-5-... 3 1
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
C-C chemokine receptor type 1 ligand N-[(2R)-1-[(4S)-4-(4-chlo... 15 6
C-C chemokine receptor type 1 ligand 4-chloro-N-[(2R)-1-[(4S)-... 6 3
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 4
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
Histamine H3 receptor ligand AGN-PC-01WA6E family 10 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 6 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-2-... 6 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 7 1
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 2 6
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 3 1
Sodium-dependent dopamine transporter and Transporter inhibito... 6 0
Substance-P receptor and Potassium voltage-gated channel subfa... 5 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 10 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor methyl ... 6 2
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 0
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
Substance-P receptor ligand SureCN8936495 family 1 0
Sodium-dependent noradrenaline transporter inhibitor AGN-PC-07... 1 1
Sodium-dependent dopamine transporter and Muscarinic acetylcho... 2 6
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 0
Histone deacetylase 1 and Histone deacetylase 8 inhibitor meth... 1 3
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[ethyl-[2-(4... 1 1
Melanocortin receptor 4 ligand NBI-12i family 1 0
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 9
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 1
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 0
Histone deacetylase 6 and Histone deacetylase 2 inhibitor 6-[[... 1 0
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[(3,4-dichlo... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor N-... 1 0
Neuromedin-K receptor and Substance-K receptor ligand AGN-PC-0... 2 0
Neutrophil collagenase and Macrophage metalloelastase inhibito... 1 0
Aldose reductase inhibitor SureCN8804611 family 2 0
Prostaglandin E synthase inhibitor AGN-PC-09QMEJ family 2 0
Substance-P receptor ligand 1-benzyl-3-[bis(4-chlorophenyl)met... 1 3
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor N-[(2S)-1-[[... 1 3
C-C chemokine receptor type 2 ligand (2S)-N-[[3,5-bis(trifluor... 1 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 2,6-d... 1 1
Dipeptidyl peptidase 4 inhibitor SureCN14523901 family 7 1
Cannabinoid receptor 1 ligand AGN-PC-078YV8 family 1 2
Beta-lactamase inhibitor CHEMBL1317875 family 1 5
Prelamin-A/C inhibitor CHEMBL1353052 family 1 1
Voltage-dependent T-type calcium channel subunit alpha-1H and ... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00296833 CHEMBL459384 Bioactive N-[(1S)-3-[4-[[2-(4-chlorophenyl)acetyl]-ethylamino]piperidin-1-yl]-1-phenylbutyl]cyclobutanecarboxamide
CFAMM00296825 CHEMBL413057 Bioactive ST50942394
CFAMM00296839 CHEMBL214630 Bioactive (2S,4S)-2-amino-4-[(4-chlorophenyl)methylamino]-5-phenyl-1-piperidin-1-ylpentan-1-one
CFAMM00296811 CHEMBL311397 Bioactive (2R)-2-[3-(4-chlorophenyl)propyl]-N-[(2S)-3-cyclohexyl-1-oxo-1-(2-phenylethylamino)propan-2-yl]-N'-hydroxybutanediamide
CFAMM00296857 CHEMBL1938516 Bioactive N-[(1S)-1-(4-chlorophenyl)-2-methylpropyl]-3-(4-phenylpiperidin-1-yl)propanamide
CFAMM00296863 CHEMBL1760315 Bioactive (2S)-6-[(4-chlorophenyl)methylamino]-2-[(4-fluoro-3,5-dimethylphenyl)methyl]-N-hydroxyhexanamide
CFAMM00296862 CHEMBL1760451 Bioactive (2S)-6-[(4-chlorophenyl)methylamino]-2-[(4-fluoro-3-methylphenyl)methyl]-N-hydroxyhexanamide
CFAMM00296841 DNC013209 Investigative Drug N1-(4-chlorobenzyl)-2-benzyl-N3-hydroxymalonamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27513 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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