CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3744
Family Name Tyrosinase Inhibitor 3-(2,4-dihydroxyphenyl)-propionic Acid Ethylester Family
No. of Seeds 3 No. of Other Members 8
Family Centroid CFAMM00297069 Functional Category Investigative Drug with Human Metabolite
Superfamily Tyrosinase and DNA polymerase Binder Superfamily
Class Class 2550

Cousin Family NamesSeedsMembers
Prostaglandin G/H synthase 2 Inhibitor Diflunisal Family 7 421
Tyrosine 3-monooxygenase Inhibitor L-tyrosine Family 4 36
Prostaglandin G/H synthase 1 Inhibitor Salicyclic Acid Family 3 39
Cyclooxygenase inhibitor salicylate derivative Aspirin family 3 234
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor Mycophenola... 4 353
Oestrogen receptor ligand Dienestrol Family 35 440
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Ipriflavone family 62 2480
taste receptor Ligand Cynarin Family 6 124
Agrimophol family 10 22
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
Free fatty acid receptor 1 Ligand TAK-875 Family 2 54
Macrophage migration inhibitory factor and Prothrombin Inhibit... 2 49
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Steryl-sulfatase Inhibitor 4-sulfamoyloxy-benzoic Acid Hexyl E... 11 1
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 I... 2 19
Steryl-sulfatase Inhibitor Sulfamic Acid 3-(4-hydroxy-benzoyl)... 3 2
Estrogen receptor beta Ligand 3,6-dihydroxy-2-(4-hydroxy-pheny... 2 23
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 127
4-aminobutyrate aminotransferase, mitochondrial and Succinate-... 4 22
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
L-selectin and P-selectin Inhibitor 2,3,4-trihydroxybenzoic Ac... 2 10
Tyrosine-protein phosphatase non-receptor type 1 Ligand Licoag... 9 32
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80
Kappa-type opioid receptor Ligand Anisocoumarin H Family 3 5
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Squalene monooxygenase Inhibitor Octyl_gallate Family 5 5
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 3 7
NAD(P)H dehydrogenase [quinone] 1 Inhibitor Ethyl Bis(4-hydrox... 5 7
Tyrosine-protein phosphatase non-receptor type 1 Ligand Kuwano... 3 3
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Amine oxidase [flavin-containing] B Inhibitor 4-oxo-4h-chromen... 2 3
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 0
Tyrosinase Inhibitor 4-adamantyl Resorcinol Family 1 1
Androgen receptor Ligand Palodesangren E Family 12 43
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 27
Protein kinase C beta type and Protein kinase C eta type inhib... 1 0
Neuropeptide Y receptor type 5 and Thioredoxin glutathione red... 13 6
G2/mitotic-specific cyclin-B1 and Cyclin-dependent kinase 1 in... 2 8
Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor propan... 3 5
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 8
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 2
Glutamate carboxypeptidase 2 inhibitor 2-[(3-hydroxyphenyl)met... 1 0
Benzopyrans Metabolite (-)-trans-3,4-Dihydro-4,8-dihydroxy-3-m... 1 0
Prenol Lipids Metabolite 13-Hydroxydihydromelleolide Family 3 0
Benzoic Acid and Derivatives Metabolite Methyl 3-(2,3-dihydrox... 1 3
Putative NP ZINC49600254 Family 8 2
Putative NP ZINC04043753 Family 8 6
2-(2-methoxyphenyl)-5-oxooxolane-3-carboxylate NP ZINC00132596... 4 2
Putative NP ZINC03197541 Family 1 0
2,4-bis(4-hydroxyphenyl)cyclobutane-1,3-dicarboxylate NP ZINC0... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00297068 DNC013261 Investigative Drug 3-(2,4-dihydroxyphenyl)propionic acid
CFAMM00297070 DNC013263 Investigative Drug 3-(2,4-dihydroxyphenyl)-propionic acid octylester
CFAMM00297069 DNC013262 Investigative Drug 3-(2,4-dihydroxyphenyl)-propionic acid ethylester

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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