CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3746
Family Name Sodium-dependent dopamine transporter and Sodium-dependent serotonin transporter Inhibitor Threo-1-aza-5-phenyl[4.4.0]decane Family
No. of Seeds 8 No. of Other Members 2
Family Centroid CFAMM00297098 Functional Category Investigative Drug
Superfamily Sodium-dependent dopamine transporter and Sodium-dependent serotonin transporter Inhibitor Threo-1-aza-5-phenyl[4.4.0]decane Superfamily
Class Class 346

Cousin Family NamesSeedsMembers
Alpha-1B adrenergic receptor ligand phenethylamine derivative ... 12 283
5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680
Adrenergic neuron Inhibitor guanidine isoquinoline analog Debr... 2 44
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Sibu... 7 127
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Amine oxidase [flavin-containing] B Inhibitor Phenelzine Family 7 15
Amine oxidase [flavin-containing] B Inhibitor Selegiline Family 6 26
Noradrenergic re-uptake Inhibitor Phentermine Family 2 11
Squalene monooxygenase Inhibitor Naftifine Family 8 32
Nuclear receptor subfamily 1 group I member 3 ligand piperazin... 3 82
Noradrenergic re-uptake Inhibitor Protriptyline Family 3 25
Beta adrenergic receptor Ligand Bretylium Family 3 11
Amine oxidase [flavin-containing] B Inhibitor Rasagiline Family 2 11
Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45
Noradrenergic re-uptake Inhibitor Maprotiline Family 6 33
Serotonin re-uptake Inhibitor Dexfenfluramine Family 6 31
Dermatan family 1 11
C-X-C chemokine receptor type 4 Ligand AMD-3100 Family 3 6
Glutamate receptor AMPA subtype and Noradrenaline uptake Ligan... 9 17
5-hydroxytryptamine receptor 2C Ligand Lorcaserin Family 8 38
Substance-P receptor Ligand Vestipitant Family 14 137
Zicronapine family 43 62
Sigma non-opioid intracellular receptor 1 Ligand Dimemorfan Fa... 5 15
Renin Inhibitor N-methyl-n-(methylbenzyl)formamide Family 2 17
Beta-secretase 1 Inhibitor 4-(4-fluorobenzyl)piperidine Family 2 4
D(2) dopamine receptor and D(3) dopamine receptor Ligand (-)-3... 15 19
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 3 7
Adenosine receptor A3 and Glutamate receptor ionotropic, NMDA ... 4 30
Dipeptidyl peptidase 4 Inhibitor 2-(2-chlorophenyl)-2-morpholi... 2 34
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 10
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
Histamine H3 receptor Ligand 1-[2-(2,4,6-trimethyl-phenyl)-eth... 9 15
Calcium-activated potassium channel subunit alpha-1 Ligand N-m... 2 10
Sodium-dependent serotonin transporter Inhibitor 1-(2-(naphtha... 5 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Potassium voltage-gated channel subfamily H member 2 Ligand [1... 2 23
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 1
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 6
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 17 9
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 4 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 1
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 4
Squalene synthase Inhibitor Zwitterionic Sulfobetaine Derivati... 2 20
Sigma non-opioid intracellular receptor 1 ligand CHEMBL101300 ... 2 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 4 2
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 7
Sodium-dependent serotonin transporter and Sodium-dependent no... 12 0
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
5-hydroxytryptamine receptor 7 and Sodium-dependent serotonin ... 5 1
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 18 4
Sigma non-opioid intracellular receptor 1 ligand 2-(3-iodophen... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 3
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 0
Transporter and Sodium-dependent serotonin transporter inhibit... 4 8
Muscarinic acetylcholine receptor M3 ligand 3-[8-(2-methoxyeth... 3 0
Sodium-dependent dopamine transporter inhibitor N-[[(1S,3S,4R,... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 9 0
Histamine H3 receptor and Acetylcholinesterase ligand 1-[4-[[4... 1 2
Sigma non-opioid intracellular receptor 1 ligand 1-[2-[4-[1-ad... 1 0
Histamine H3 receptor ligand SureCN1641166 family 3 0
5-hydroxytryptamine receptor 1A ligand SureCN8901985 family 1 0
Histamine H3 receptor ligand 2-benzyl-4-[4-(2-pyrrolidin-1-yle... 8 4
Histamine H3 receptor ligand (3aR,6aR)-2-propan-2-yl-4-[4-(2-p... 6 5
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 7
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
D(1A) dopamine receptor and D(2) dopamine receptor ligand A314... 3 1
Vesicular acetylcholine transporter inhibitor (1R,2R)-2-spiro[... 3 2
C-C chemokine receptor type 5 ligand 1-[[(3S,4S)-1-(cyclohexyl... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 2
Histamine H3 receptor ligand 1-[4-[4-(pyrrolidin-1-ylmethyl)ph... 4 2
D(2) dopamine receptor ligand AGN-PC-041NNJ family 1 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 1
Melanocortin receptor 4 ligand 1-[3-[2-(4-tert-butylphenyl)phe... 1 3
1-[(E)-3-phenylprop-2-enyl]-4-[[(4S)-4-prop-1-en-2-ylcyclohexe... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00297093 CHEMBL291228 Bioactive 1-cyclohexyl-3-[(E)-2-phenylethenyl]piperidine
CFAMM00297092 CHEMBL1824789 Bioactive CHEMBL1824789
CFAMM00297096 CHEMBL420291 Bioactive (3S,4S)-8-methyl-3-phenyl-4-propyl-8-azabicyclo[3.2.1]octane
CFAMM00297095 CHEMBL144552 Bioactive SureCN11205656
CFAMM00297094 CHEMBL39806 Bioactive 1-cyclohexyl-3-[(Z)-2-phenylethenyl]piperidine
CFAMM00297098 DNC013271 Investigative Drug threo-1-aza-5-phenyl[4.4.0]decane hydrochloride

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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