CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFID3755
Family Name Delta-type opioid receptor and Mu-type opioid receptor Ligand N Alpha-amidino-tyr(me)-pro-trp-p-cl-phe-nh2 Family
No. of Seeds 18 No. of Other Members 72
Family Centroid CFAMM00297331 Functional Category Investigative Drug with Natural Product
Superfamily Delta-type opioid receptor and Mu-type opioid receptor Ligand N Alpha-amidino-tyr(me)-pro-trp-p-cl-phe-nh2 Superfamily
Class Class 897

Cousin Family NamesSeedsMembers
Leutinizing-hormone-releasing hormone inhibitor peptide Leupro... 43 911
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Cysteinyl leukotriene receptor 1 Ligand Zafirlukast Family 48 78
Gonadotropin-releasing hormone receptor Ligand decapeptide ana... 9 162
Epidermal Growth Factor family 111 209
DNA Binder Primaquine Family 3 245
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Parathyroid hormone/parathyroid hormone-related peptide recept... 55 256
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
Insulin receptor Ligand Insulin, Porcine Family 61 205
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
HIV-1 protease Inhibitor Atazanavir Family 16 58
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Gastrin/cholecystokinin type B receptor ligand oligopeptide Ce... 35 209
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
5-hydroxytryptamine receptor Ligand Metergolin Family 2 11
DNA Binder Elliptinium Acetate Family 11 116
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Mast/stem cell growth factor receptor Kit and Vascular endothe... 1 4
Substance-P receptor Ligand GSK424887 Family 8 184
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Vascular endothelial growth factor receptor 2 Ligand E 7080 Fa... 7 17
Growth hormone receptor Ligand EP-51216 Family 34 390
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
NS5A protein Inhibitor Bms 790052 Family 5 9
BIBT986 family 7 96
CBP-501 family 7 8
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
AEZS-108 family 5 2
Indeglitazar family 3 39
Eluxadoline family 4 85
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Lethal factor Inhibitor GM6001 Family 50 435
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Renin Inhibitor Enalkiren Family 56 44
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Chymase Inhibitor NK3201 Family 1 0
Tyrosine kinase Inhibitor PKI166 Family 17 198
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibi... 1 8
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
5-hydroxytryptamine receptor 3A and Alpha-2A adrenergic recept... 31 24
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Renin Inhibitor (h-261)boc-his-pro-phe-his-leu(oh)-val-ile-his... 33 41
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Plasminogen and Prothrombin Inhibitor 2-(2-hydroxy-phenyl)-1h-... 3 69
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-his-agly-ile-v... 3 2
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Alpha-1A adrenergic receptor Ligand A-131701 Family 16 17
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
D(2) dopamine receptor Ligand SLV-314 Family 19 69
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Delta-type opioid receptor and Gastrin/cholecystokinin type B ... 19 0
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
Platelet-derived growth factor receptor alpha and Platelet-der... 2 13
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 50 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 36 15
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 2 3
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Angiotensin-converting enzyme and Endothelin-converting enzyme... 2 10
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 13 15
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Falcipain-2B Inhibitor FITC-LMNNAEHINQFYMFI Family 3 5
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Histone deacetylase Inhibitor ST-5732 Family 8 6
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 46 0
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Potassium voltage-gated channel subfamily H member 2 Ligand (1... 64 70
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Transient receptor potential cation channel subfamily V member... 2 12
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
C-C chemokine receptor type 5 ligand AC1LAJEM family 4 14
C-C chemokine receptor type 5 ligand (2,4-dimethyl-1-oxidopyri... 5 4
Pol polyprotein inhibitor pyridin-2-ylmethyl N-[(2R)-1-[[(2S,3... 15 8
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16f ... 3 18
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 1 18
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 7 16
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 3 28
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 5 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 1
Neutrophil collagenase and Stromelysin-3 inhibitor AC1MORIH fa... 7 9
5-hydroxytryptamine receptor 6 ligand N-[3-[[(2R)-1-methylpyrr... 6 0
Protein farnesyltransferase subunit beta and Protein farnesylt... 3 0
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 3 5
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 8 8
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Acetylcholinesterase and Muscarinic acetylcholine receptor M2 ... 2 7
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-[3-cy... 2 5
Aurora kinase A inhibitor SureCN761545 family 2 2
Aurora kinase A inhibitor SureCN761045 family 2 0
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 5 40
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 2 0
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Renin inhibitor AGN-PC-09M9MJ family 2 23
Casein kinase I isoform delta and Mitogen-activated protein ki... 3 18
Pol polyprotein and Cytochrome P450 3A4 inhibitor P3 arylpyrro... 19 1
Renin inhibitor (1R,5S)-N-cyclopropyl-N-[(2-methoxy-3-methylpy... 2 3
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 5 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 2 15
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 4 53
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-... 2 9
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Somatostatin receptor type 2 ligand (2R,3S)-N-[(5-amino-1,3-di... 2 5
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
Renin and Cathepsin D inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-... 2 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Prostaglandin D2 receptor 2 ligand SureCN137822 family 3 0
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 3
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
Platelet-activating factor receptor ligand SureCN7497229 family 4 2
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... 17 4
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 0
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
Pol polyprotein inhibitor propan-2-yl N-[(2S)-1-[[(2S,3S,5R)-3... 6 2
Histone deacetylase inhibitor (3S,6S,9S,12R)-3-[(2S)-butan-2-y... 1 0
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (3S,... 1 16
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 6
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Renin inhibitor [2-(3-fluoro-2,6-dimethylphenoxy)-1-phenylpyrr... 5 12
Retinoic acid receptor RXR-alpha ligand (E)-3-[3-(3,5-ditert-b... 5 5
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 2 11
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 1
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 9 4
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 2
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 3 4
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 3
Renin and Potassium voltage-gated channel subfamily H member 2... 13 11
Renin and Potassium voltage-gated channel subfamily H member 2... 4 0
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Prothrombin and Cationic trypsin inhibitor (2S)-1-[(2R)-3,3-di... 5 9
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Histamine H3 receptor ligand AGN-PC-075YXY family 1 4
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Vascular endothelial growth factor receptor 2 and Vascular end... 2 52
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Cholinesterase and Acetylcholinesterase inhibitor 4-oxo-N-[9-(... 11 13
Platelet-derived growth factor receptor beta and Macrophage co... 1 4
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Dual specificity protein kinase TTK inhibitor 2-[1-[4-[[6-(cyc... 8 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Type-1 angiotensin II receptor ligand N-[2-(3-methoxyphenyl)et... 2 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 0
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
Plasmepsin-2 and Cathepsin D inhibitor 4-[4-[[(2S,3S)-1-[[(3S,... 3 0
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 3 2
Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... 5 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Growth hormone secretagogue receptor type 1 ligand SureCN36380... 6 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 159
KiSS-1 receptor ligand (2S)-N-[(2S)-1-[[(2S)-4-amino-1-[[(2S)-... 3 0
Pancreatic alpha-amylase and Gastrin/cholecystokinin type B re... 7 1
Cathepsin K inhibitor (1R,2R)-N-(1-cyanocyclopropyl)-2-(6-meth... 3 0
Mu-type opioid receptor and Mu-type opioid receptor ligand (3S... 6 2
Fatty-acid amide hydrolase 1 inhibitor [3-(3-carbamoylpyrrol-1... 4 6
Substance-P receptor ligand AGN-PC-01VLKE family 9 11
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 1 1
Acetylcholinesterase and Cholinesterase inhibitor N-[5-[(6-chl... 4 2
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 1 1
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 3 5
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-[5-(diflu... 7 0
Beta-2 adrenergic receptor ligand SureCN5346426 family 8 0
Beta-2 adrenergic receptor ligand SureCN4598646 family 7 7
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 0
Cholinesterase and Acetylcholinesterase inhibitor 6-[4-[2-fluo... 17 0
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 3
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Growth hormone secretagogue receptor type 1 ligand N-[(1R)-2-(... 3 2
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Disintegrin and metalloproteinase domain-containing protein 17... 5 4
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Bifunctional epoxide hydrolase 2 inhibitor 8-(quinoline-5-carb... 1 0
Egl nine homolog 1 inhibitor 2-(2-methoxy-4-phenylphenyl)-8-[(... 1 0
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Transient receptor potential cation channel subfamily V member... 6 1
Collagenase 3 inhibitor 1-[6-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Glutamate receptor ionotropic, NMDA 2B ligand SureCN5532501 fa... 1 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 1 2
C-C chemokine receptor type 2 ligand (E)-1-[4-[2-hydroxy-1-[4-... 2 2
Vasopressin V2 receptor and Vasopressin V1a receptor ligand 2-... 1 26
Proteinase-activated receptor 1 and Prothrombin ligand (2S)-N-... 3 23
Coagulation factor VII inhibitor CHEMBL269354 family 1 0
Pol polyprotein inhibitor Palinavir deriv. 13 family 1 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
Neutrophil collagenase and Stromelysin-3 inhibitor [3-[[1-amin... 3 2
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 8 13
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Platelet-activating factor receptor ligand N,N-dimethyl-6-phen... 12 18
Neutrophil collagenase and Stromelysin-1 inhibitor (3R)-N-hydr... 2 0
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
Pol polyprotein and Protease inhibitor 161186-51-2 family 5 0
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 1
Neutrophil collagenase and Matrix metalloproteinase-9 inhibito... 1 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 15
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 1 4
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
Substance-P receptor ligand SureCN2139814 family 7 7
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Endothelin B receptor and Endothelin-1 receptor ligand N-[(2R)... 12 3
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 7
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 2
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 6 4
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
5-hydroxytryptamine receptor 6 ligand 2-[(2Z)-2-[3-[(3-methoxy... 1 11
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Gonadotropin-releasing hormone receptor ligand methyl 4-[2-[[(... 2 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 1
Gastrin/cholecystokinin type B receptor ligand CHEMBL338525 fa... 1 10
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 1
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 5 2
Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy... 1 1
Melanocyte-stimulating hormone receptor and Melanocortin recep... 1 0
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 1 3
KiSS-1 receptor ligand [2-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S... 1 1
KiSS-1 receptor ligand SureCN5132924 family 2 4
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... 2 10
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 4 1
KiSS-1 receptor ligand N-[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-... 1 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-methoxypheny... 1 0
Substance-P receptor ligand AGN-PC-00FIT5 family 3 11
CGMP-dependent protein kinase inhibitor AGN-PC-0761UG family 1 2
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 1 0
Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methox... 1 2
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 15 1
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
Protein kinase C theta type and Protein kinase C delta type in... 10 7
Cholecystokinin receptor type A ligand AGN-PC-077KXF family 2 0
Histidinol dehydrogenase inhibitor (3S)-3-amino-1-(1,3-benzodi... 1 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Acyl-CoA desaturase inhibitor SureCN1182719 family 1 0
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
5-hydroxytryptamine receptor 4 ligand 4-amino-5-chloro-N-[1-[8... 2 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 5 1
Bombesin receptor subtype-3 ligand 2-[[(E)-furan-2-ylmethylide... 2 4
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 3
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 1 0
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 2 1
Pol polyprotein inhibitor N-benzyl-2,2-difluoro-4-[[(2S)-3-met... 1 1
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-08866Z fa... 2 0
Leucyl-cystinyl aminopeptidase inhibitor SureCN988709 family 1 14
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 2 10
E3 ubiquitin-protein ligase Mdm2 and Protein Mdm4 inhibitor CH... 2 1
Melanocortin receptor 4 and Melanocortin receptor 3 ligand (2S... 1 0
Sphingosine 1-phosphate receptor 1 ligand (2S)-2-[[2-(1H-imida... 4 7
Phospho-N-acetylmuramoyl-pentapeptide-transferase inhibitor (2... 1 1
Coagulation factor VII and Tissue factor inhibitor 5-azaindole... 4 3
Histone deacetylase 1 inhibitor (2S)-2-[[2-(5-methoxy-2-methyl... 2 2
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 1
C-X-C chemokine receptor type 2 ligand 4-[5-cyano-2-(4-fluorop... 1 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Lutropin-choriogonadotropic hormone receptor ligand 5-[2-(4-te... 1 1
Bile acid receptor ligand SureCN1243717 family 1 4
Caspase-3 and Caspase-7 inhibitor (2S)-N-[(3S)-2-hydroxy-5-oxo... 4 1
DNA polymerase beta and Cruzipain inhibitor CHEMBL1462186 family 1 0
Platelet-derived growth factor receptor beta and Vascular endo... 1 3
Vascular endothelial growth factor receptor 2 ligand (2Z)-2-[[... 1 0
Oxysterols receptor LXR-beta ligand indole derivative, 39 family 2 0
Coagulation factor VII and Tissue factor inhibitor 5-azaindole... 1 0
Pol polyprotein inhibitor Phenprocoumon IndolEtCONH deriv. family 2 0
Indoleamine 2,3-dioxygenase 1 inhibitor CHEMBL576950 family 1 0
Indoles Metabolite 4-[N-(p-Coumaroyl)serotonin-4''-yl]-N-ferul... 3 0
NP N-(1h-indol-6-yl)-3-(4-methoxy-1h-indol-1-yl)propanamide Fa... 2 0
Putative NP ZINC40309500 Family 4 0
Putative NP ZINC40310254 Family 74 1
NP N1-(5-bromo-1-ethyl-2-oxoindolin-3-yl)-N2-(2-(5-methoxy-1H-... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00297395 CHEMBL198771 Bioactive N-[(2R)-1-[[(2S)-1-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-4-(4-methoxyphenyl)-1-(pentanoylamino)cyclohexane-1-carboxamide
CFAMM00297342 CHEMBL412984 Bioactive (2R)-1-[(2R)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-(4-chlorophenyl)propanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]-N-[(2R)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00297372 CHEMBL373212 Bioactive N-[(2R)-1-[[(2S)-1-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-1-(pentanoylamino)-4-(4-propan-2-yloxyphenyl)cyclohexane-1-carboxamide
CFAMM00297363 CHEMBL7610 Bioactive RWJ-54003
CFAMM00297406 CHEMBL539937 Bioactive AGN-PC-073OG1
CFAMM00297331 DNC013334 Investigative Drug N alpha-amidino-Tyr(Me)-Pro-Trp-p-Cl-Phe-NH2

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27523 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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