CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3758
Family Name 5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)piperidin-4-yl)-2-naphthamide Family
No. of Seeds 4 No. of Other Members 6
Family Centroid CFAMM00297416 Functional Category Investigative Drug
Superfamily 5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)piperidin-4-yl)-2-naphthamide Superfamily
Class Class 1625

Cousin Family NamesSeedsMembers
5-alpha reductase inhibitor azasteroid derivative Dutasteride ... 36 124
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Mu-type opioid receptor Ligand Fentanyl Family 9 647
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
DNA Binder Procarbazine Family 8 358
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Motilin receptor Ligand GSK962040 Family 30 457
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
K-604 family 4 71
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Pan-DAC Inhibitor AR-42 Family 21 153
Amonafide family 3 35
Bavisant family 9 65
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Delta-type opioid receptor Ligand Sb 227122 Family 7 5
C-C chemokine receptor type 5 Ligand Tak-220 Family 8 56
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Vasopressin-neurophysin 2-copeptin Inhibitor Niravoline Family 7 45
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Vasopressin V2 receptor Ligand VP-343 Family 1 0
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Urokinase-type plasminogen activator Inhibitor 6-(n-phenylcarb... 2 11
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
Poly [ADP-ribose] polymerase 1 Inhibitor 3,4-dihydro-5-methyl-... 3 2
Epidermal growth factor receptor Ligand 5,6-bis-p-tolylamino-i... 2 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Integrin beta-3 Inhibitor L-767679 Family 3 6
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 3
Integrin beta-3 Inhibitor L-750034 Family 7 38
Integrin beta-3 Inhibitor SB-208651 Family 9 28
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Poly [ADP-ribose] polymerase 1 Inhibitor 8-amino-6h,11h-indeno... 3 9
Transient receptor potential cation channel subfamily V member... 6 33
Poly [ADP-ribose] polymerase 1 Inhibitor 3-morpholin-4-ylmethy... 1 2
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 13
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Tic... 11 31
Acetylcholinesterase Inhibitor Bw-28c51 Family 3 8
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
Aurora kinase B Inhibitor Hesperadin Family 1 1
Integrin alpha-2 and Integrin beta-3 Inhibitor 3-(3-(carbamoyl... 7 13
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 13
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Serine/threonine-protein kinase Chk1 Inhibitor 6-(3-aminopropy... 2 7
Transient receptor potential cation channel subfamily V member... 1 5
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Telomerase reverse transcriptase Inhibitor 2,7-bis[2-(piperidi... 6 8
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 2 17
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 7
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Inhibit... 5 23
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 12 4
D(2) dopamine receptor Ligand PD-168077 Family 6 5
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 2 7
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(3-cyanophe... 7 5
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Dihydroorotate dehydrogenase Inhibitor N-(4-bromo-2-methylphen... 1 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Substance-P receptor ligand AGN-PC-00FJ8P family 6 10
D(4) dopamine receptor ligand AGN-PC-074VC9 family 2 3
Vasopressin V1a receptor ligand AGN-PC-074VJP family 3 1
Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)am... 6 3
Substance-K receptor ligand 4-(4-methylphenyl)-N-[1-[[(2S)-5-[... 6 0
Acetylcholinesterase inhibitor AGN-PC-07ZFTY family 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEDE family 7 17
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZFJZ family 1 3
Vasopressin V1a receptor ligand AGN-PC-074VSA family 3 0
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 4 8
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 15 24
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
C-C chemokine receptor type 5 ligand AC1L9USC family 3 2
Progesterone receptor and Androgen receptor ligand AGN-PC-080P... 4 27
Cathepsin K and Cathepsin B inhibitor AGN-PC-01Z23J family 2 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 7 5
C-C chemokine receptor type 3 ligand 4-[(3-acetylphenyl)carbam... 3 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 4
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7345980... 4 6
C-C chemokine receptor type 3 ligand SureCN6703027 family 2 1
Acetylcholinesterase inhibitor CHEMBL1651130 family 2 3
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 3
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 7 1
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 10 0
Acetylcholinesterase inhibitor 2-[2-(1-benzylpiperidin-4-yl)et... 2 9
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 3 0
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 6 5
Sigma non-opioid intracellular receptor 1 ligand 2-(2-nitrophe... 2 5
Hypoxia-inducible factor 1-alpha and Ubiquitin carboxyl-termin... 1 1
D(3) dopamine receptor and Alpha-1B adrenergic receptor ligand... 11 8
Prelamin-A/C inhibitor CHEMBL1547148 family 1 8
Peptide deformylase inhibitor (2R)-2-[[formyl(hydroxy)amino]me... 2 1
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 8 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Neuromedin-K receptor ligand SureCN2477089 family 2 4
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 24 11
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 6
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 3
Mitogen-activated protein kinase 14 and Cytochrome P450 2C9 in... 2 0
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 2 4
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 8 1
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 6 9
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 3 5
Follicle-stimulating hormone receptor ligand AGN-PC-005HER family 5 2
C-C chemokine receptor type 3 and Sodium-dependent serotonin t... 12 2
Delta-type opioid receptor and Potassium voltage-gated channel... 3 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 2 1
Transient receptor potential cation channel subfamily V member... 1 1
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
C-C chemokine receptor type 2 ligand N-[2-[[(2S,3S)-1-[(2,4-di... 13 8
C-C chemokine receptor type 2 ligand N-[3-amino-5-(trifluorome... 4 1
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 19
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Histamine H3 receptor and Potassium voltage-gated channel subf... 9 0
Bifunctional epoxide hydrolase 2 inhibitor 1-(3-acetylphenyl)-... 1 3
Substance-P receptor and Potassium voltage-gated channel subfa... 5 0
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 2 17
Transient receptor potential cation channel subfamily A member... 1 1
Nociceptin receptor ligand 2-[3-[1-[(1R)-1,2-dihydroacenaphthy... 2 0
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 5 2
Melanin-concentrating hormone receptor 1 ligand AGN-PC-0762XZ ... 3 1
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(cyanomethyl)-... 1 6
C-C chemokine receptor type 3 ligand 1-(3-acetylphenyl)-3-[3-[... 9 1
Mitogen-activated protein kinase 14 inhibitor 3-(3-benzamido-4... 2 0
P2X purinoceptor 7 inhibitor 2-[3-fluoro-4-(trifluoromethyl)ph... 3 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
Vasopressin V1a receptor and Vasopressin V2 receptor ligand Su... 1 1
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 11
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
5-hydroxytryptamine receptor 7 ligand 2-[4-[4-(2-oxo-1,3,4,5-t... 1 0
Proteinase-activated receptor 1 ligand 2-[[2-[[2-[acetyl-[(E)-... 6 15
C-C chemokine receptor type 3 ligand SureCN3935453 family 4 11
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 7 12
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 2
Atrial natriuretic peptide receptor 1 and Atrial natriuretic p... 3 0
Growth hormone secretagogue receptor type 1 ligand SureCN77944... 1 2
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 4 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
Mitogen-activated protein kinase 14 inhibitor 5-(2-chloro-4-fl... 3 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 1
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 3 0
Protease and Replicase polyprotein 1a inhibitor AC1LALLS family 1 0
C-C chemokine receptor type 3 ligand AGN-PC-075BAT family 1 0
Vascular endothelial growth factor receptor 2 ligand isoindoli... 1 0
Transient receptor potential cation channel subfamily V member... 1 1
Histone deacetylase 6 and Histone deacetylase 2 inhibitor 4-[[... 2 1
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
Muscarinic acetylcholine receptor M3 ligand N-[[4-fluoro-3-[3-... 3 0
Mitogen-activated protein kinase 14 inhibitor 3-(2-amino-4-oxo... 1 2
Urotensin-2 receptor and Kappa-type opioid receptor ligand Sur... 2 1
Vascular endothelial growth factor receptor 2 ligand SureCN578... 1 2
Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family 2 1
Mitogen-activated protein kinase 14 and Serine/threonine-prote... 1 1
D(1A) dopamine receptor and D(3) dopamine receptor ligand 1-[4... 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 1 0
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-[2-(1-hydroxy-3... 3 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 3 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 3
Neutrophil elastase inhibitor 1-[(2S)-3-methyl-2-[(4-nitrobenz... 1 1
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
C-C chemokine receptor type 5 ligand AC1MHP8Y family 1 0
Glucagon receptor and Adenylate cyclase type 1 ligand AGN-PC-0... 1 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1
Histone deacetylase 1 inhibitor AGN-PC-07ZGOT family 2 1
Tyrosine-protein kinase ITK/TSK and Mast/stem cell growth fact... 1 0
Glucose-dependent insulinotropic receptor ligand AGN-PC-04UO8L... 2 2
B1 bradykinin receptor ligand 4-(4-oxothiochromen-3-yl)-N-[(1R... 1 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[[1... 2 5
E3 ubiquitin-protein ligase XIAP and Cytochrome P450 3A4 inhib... 2 0
Coagulation factor X and Coagulation factor VII inhibitor AGN-... 1 2
Histone deacetylase 1 inhibitor 2-[4-[(2-aminophenyl)carbamoyl... 1 1
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-04XL6C family 2 0
Cyclin-dependent kinase 4 inhibitor SureCN3569974 family 1 0
Glutathione reductase, mitochondrial inhibitor (S)-2-(4-Nitrob... 1 3
Progesterone receptor ligand AGN-PC-00PB7N family 2 1
Acenes Metabolite C.I. Pigment Red 149 Family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00297424 CHEMBL340131 Bioactive SureCN4929265
CFAMM00297420 CHEMBL516127 Bioactive SureCN5106052
CFAMM00297416 DNC013345 Investigative Drug N-(1-(4-nitrobenzyl)piperidin-4-yl)-2-naphthamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24517 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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