CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3760
Family Name Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methylquinolin-7-yl)benzonitrile Family
No. of Seeds 7 No. of Other Members 27
Family Centroid CFAMM00297453 Functional Category Investigative Drug with Natural Product
Superfamily Metabotropic glutamate receptor 5 and E3 ubiquitin-protein ligase Mdm2 Binder Superfamily
Class Class 1788

Cousin Family NamesSeedsMembers
DNA topoisomerase 2-beta inhibitor acridine derivative Amsacri... 1 4
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Dihydroorotate dehydrogenase Inhibitor LY214352 Family 2 17
Cytochrome b Inhibitor 2-nonyl-4-hydroxyquinoline N-OXIDE Family 2 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Acetylcholinesterase Inhibitor Velnacrine Family 2 29
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Melanin-concentrating hormone receptor 1 Ligand 8-sec-butoxy-q... 30 39
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-((3-methox... 3 9
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 38 35
Metabotropic glutamate receptor 5 Ligand 3-hydroxy-5-(2-methyl... 2 1
Metabotropic glutamate receptor 5 Ligand (3-(2-methylquinolin-... 3 6
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YQD... 1 5
Neuropeptide Y receptor type 1 ligand SureCN7959923 family 1 6
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 5
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
Leukotriene B4 receptor 1 ligand SureCN8987110 family 8 20
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
Arachidonate 5-lipoxygenase inhibitor (2E)-2-[2-butyl-1-[4-(qu... 1 12
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Prostaglandin D2 receptor 2 ligand SureCN137822 family 3 0
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
Cysteinyl leukotriene receptor 1 ligand SureCN7008285 family 12 97
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
Corticotropin-releasing factor receptor 1 ligand 2-(2-ethyl-4,... 4 9
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 12 3
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Corticotropin-releasing factor receptor 1 ligand 3-ethyl-1-(2-... 5 15
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[4... 7 4
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[2... 4 4
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 3 5
C5a anaphylatoxin chemotactic receptor 1 ligand 2-(2,6-diethyl... 3 5
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
Prothrombin and Trypsin-1 inhibitor AGN-PC-074I4I family 3 1
Proteinase-activated receptor 1 ligand (3R,3aS,4S,4aR,8aS,9aR)... 1 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Adenosine receptor A1 ligand BAS 00727702 family 1 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 2
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Dipeptidyl peptidase 4 inhibitor 2-[3-(aminomethyl)-4-(4-fluor... 3 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 4
Arachidonate 5-lipoxygenase inhibitor 4-(furan-3-yl)-7-[[5-(4-... 2 1
Coagulation factor X and Cationic trypsin inhibitor 1qb6 family 4 15
Beta-lactamase and Muscleblind-like protein 1 inhibitor 2,3-Bi... 1 2
Metabotropic glutamate receptor 1 ligand (Z)-[(3-ethyl-2-metho... 1 4
2,4,6-trimethyl-2,3-dihydrofuro[3,2-c]quinoline NP ZINC0009476... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00297470 DNC013371 Investigative Drug 7-(3-methoxyphenyl)-2-methylquinoline
CFAMM00297462 DNC013351 Investigative Drug 3-isobutoxy-5-(2-methylquinolin-7-yl)benzonitrile
CFAMM00297467 DNC013362 Investigative Drug 7-(2-methoxyphenyl)-2-methylquinoline
CFAMM00297474 DNC014347 Investigative Drug 2-Benzoxy-5-(2-methylquinolin-7-yl)benzonitrile
CFAMM00297453 DNC013356 Investigative Drug 3-methoxy-5-(2-methylquinolin-7-yl)benzonitrile
CFAMM00297452 DNC013354 Investigative Drug 3-ethoxy-5-(2-methylquinolin-7-yl)benzonitrile
CFAMM00297472 DNC013361 Investigative Drug 7-(4-methoxyphenyl)-2-methylquinoline

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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