CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3774
Family Name Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naphthyridin-3-yl)benzonitrile Family
No. of Seeds 4 No. of Other Members 20
Family Centroid CFAMM00297570 Functional Category Investigative Drug
Superfamily Metabotropic glutamate receptor 5 and Platelet-derived growth factor receptor beta Binder Superfamily
Class Class 24

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Calcium-activated potassium channel subunit alpha-1 Ligand Qui... 3 46
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
DNA Binder Elliptinium Acetate Family 11 116
Na+-K+-ATPase transmembrane protein Inhibitor Sanguinarine Family 8 20
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Multidrug resistance protein 3 Inhibitor LY335979 Family 1 3
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
SB1518 family 7 103
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Apricoxib family 8 77
Indeglitazar family 3 39
PF-02545920 family 16 140
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Dihydroorotate dehydrogenase Inhibitor LY214352 Family 2 17
Tyrosine kinase Inhibitor PKI166 Family 17 198
Cytochrome b Inhibitor 2-nonyl-4-hydroxyquinoline N-OXIDE Family 2 22
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 5 23
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Platelet-derived growth factor receptor alpha and Platelet-der... 6 8
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 0
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 13 26
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 5
D(2) dopamine receptor Ligand SLV-314 Family 19 69
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... 3 7
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-((3-methox... 3 9
Squalene synthase Inhibitor ER-119884 Family 2 3
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Indoleamine 2,3-dioxygenase 1 Inhibitor 5-aminoquinolin-8-ol F... 3 16
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-m... 2 12
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methyl... 7 27
Metabotropic glutamate receptor 5 Ligand 3-hydroxy-5-(2-methyl... 2 1
Metabotropic glutamate receptor 5 Ligand (3-(2-methylquinolin-... 3 6
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Progesterone receptor and Glucocorticoid receptor ligand (5Z)-... 5 2
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YQD... 1 5
5-hydroxytryptamine receptor 6 ligand N-[3-[[(2R)-1-methylpyrr... 6 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 5
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Neuropeptide Y receptor type 1 ligand SureCN7959923 family 1 6
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 5 40
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 2 0
5-hydroxytryptamine receptor 6 ligand SureCN5502542 family 4 2
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 3 18
5-hydroxytryptamine receptor 2C and Cytochrome P450 1A2 ligand... 6 4
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL15681... 1 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
D(2) dopamine receptor ligand 129722-25-4 family 2 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Prostaglandin D2 receptor 2 ligand SureCN137822 family 3 0
Progesterone receptor and Androgen receptor ligand AGN-PC-04QD... 1 0
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS5MA ... 3 4
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 0
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 2 2
Somatostatin receptor type 2 ligand SureCN4317006 family 10 1
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Retinoic acid receptor RXR-alpha ligand (E)-3-[3-(3,5-ditert-b... 5 5
Sigma non-opioid intracellular receptor 1 ligand 6-methoxy-1'-... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 42 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 10
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Integrase inhibitor (Z)-4-[1-[(4-fluorophenyl)methyl]-5-methox... 1 0
Serine/threonine-protein kinase B-raf inhibitor pyrrole-based ... 2 0
RAC-alpha serine/threonine-protein kinase inhibitor N-[(2S)-1-... 2 1
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Neuronal acetylcholine receptor subunit alpha-7 ligand 5-[6-[[... 1 0
Beta-secretase 1 inhibitor CHEMBL2152919 family 1 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Sodium-dependent serotonin transporter and Histamine H3 recept... 6 4
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Egl nine homolog 1 inhibitor 2-(2-methoxy-4-phenylphenyl)-8-[(... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 19 11
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Corticotropin-releasing factor receptor 1 ligand 3-ethyl-1-(2-... 5 15
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[2... 4 4
C5a anaphylatoxin chemotactic receptor 1 ligand 2-(2,6-diethyl... 3 5
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Renin inhibitor SureCN6043852 family 2 0
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Dihydrofolate reductase and Dihydrofolate reductase type 1 inh... 8 1
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
D(1A) dopamine receptor and D(3) dopamine receptor ligand RU-2... 3 4
5-hydroxytryptamine receptor 6 ligand 1-[9-(2,5-dimethoxypheny... 2 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
Oxytocin receptor and Vasopressin V1a receptor ligand 4-methox... 9 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
Glucocorticoid receptor ligand SureCN3894124 family 3 0
Protein kinase C theta type and Protein kinase C delta type in... 10 7
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 2
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 14 2
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 2 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[7-(2-chloropheny... 2 0
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-07PXWQ f... 3 2
Dipeptidyl peptidase 4 inhibitor 2-[3-(aminomethyl)-4-(4-fluor... 3 0
Corticotropin-releasing factor receptor 1 ligand 2-[2,6-dimeth... 10 10
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Reverse transcriptase/RNaseH inhibitor 6Et-7,9-diMe-PBOA-5thio... 1 1
Acetylcholinesterase and Cholinesterase inhibitor P10358 family 2 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 4
Small conductance calcium-activated potassium channel protein ... 1 1
Beta-lactamase and Muscleblind-like protein 1 inhibitor 2,3-Bi... 1 2
Metabotropic glutamate receptor 1 ligand (Z)-[(3-ethyl-2-metho... 1 4
NP 3-(6-chloro-1h-indol-1-yl)-1-(6,7-dimethoxy-3,4-dihydroisoq... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00297568 CHEMBL198432 Bioactive AGN-PC-075Y8O
CFAMM00297574 CHEMBL238346 Bioactive AGN-PC-076BU0
CFAMM00297570 DNC013398 Investigative Drug 3-methoxy-5-(1,5-naphthyridin-3-yl)benzonitrile
CFAMM00297583 DNC013403 Investigative Drug 3-methoxy-5-(1,6-naphthyridin-7-yl)benzonitrile

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27510 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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