CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFID38
Family Name C-C chemokine receptor type 3 Ligand YM-344031 Family
No. of Seeds 19 No. of Other Members 106
Family Centroid CFAMM00175833 Functional Category Investigative Drug with Natural Product
Superfamily Substance-P receptor Ligand TAK-637 Superfamily
Class Class 840

Cousin Family NamesSeedsMembers
Receptor-type tyrosine-protein kinase FLT3 inhibitor indoline ... 4 151
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Amrino... 3 55
HIV protease Inhibitor Saquinavir Family 64 428
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Gamma-aminobutyric acid A receptor Ligand Bromazepam Family 2 60
Histamine H1 receptor Ligand Triprolidine Family 19 316
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
26S proteasome Inhibitor Bortezomib Family 7 65
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
Prothrombin Inhibitor Dabigatran Family 7 182
Transient receptor potential cation channel subfamily V member... 15 158
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Histidine decarboxylase Inhibitor Bf-derm1 Family 12 95
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Histone deacetylase 1 Inhibitor MS-275 Family 4 41
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Receptor-type tyrosine-protein kinase FLT3 Inhibitor SU5614 Fa... 4 36
Thromboxane A2 receptor Ligand Bibv 308 Family 14 40
Substance-P receptor Ligand GSK424887 Family 8 184
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Reverse transcriptase Inhibitor IDX899 Family 2 118
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Coagulation factor X Inhibitor Otamixaban Family 9 21
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Growth hormone receptor Ligand EP-51216 Family 34 390
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
D(4) dopamine receptor Ligand SPI-376 Family 7 84
Substance-P receptor Ligand TAK-637 Family 18 63
Amg 423 family 7 47
Setipiprant family 5 118
ABC294640 family 5 75
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
CP-18770 family 6 27
Pixantrone family 2 3
JAK Inhibitor Momelotinib Family 33 83
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
C-C chemokine receptor type 5 Ligand Sch 351125 Family 6 29
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
PF-4136309 family 16 27
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
NF-kappa-B and Protein kinase C zeta type Inhibitor Go6976 Family 9 71
Arachidonate 5-lipoxygenase Inhibitor Ici 207968 Family 3 7
Class II cytokine receptor Ligand IL-10 Family 7 45
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-chlorophenyl)-5-... 2 8
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Aromatase Inhibitor Rogletimide Family 1 2
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Integrin beta-3 Inhibitor Elarofiban Family 28 45
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 4
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
Cyclin-dependent kinase 1 and G2/mitotic-specific cyclin-B1 In... 2 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 3 5
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Histone deacetylase 6 Inhibitor N-(quinolin-3-yl)-6-(sulfamoyl... 4 8
Alpha-1A adrenergic receptor Ligand L-771688 Family 8 14
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Cannabinoid receptor 2 Ligand JWH-204 Family 6 10
Cannabinoid receptor 2 Ligand JWH-249 Family 7 13
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Amine oxidase [flavin-containing] B Inhibitor Lazebemide Family 2 13
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 5 10
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
Poly [ADP-ribose] polymerase 1 Inhibitor 2-ethylquinoline-8-ca... 3 4
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Gonadotropin-releasing hormone receptor Ligand [d-ncy(methyl)4... 32 0
Serine/threonine-protein kinase Chk1 Inhibitor BIS-IMIDE A Family 1 3
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 19 12
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
5-hydroxytryptamine receptor 2C Ligand Cyclo[(6-bromotryptopha... 3 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Peroxisome proliferator-activated receptor gamma Ligand 2-chlo... 5 19
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Urotensin-2 receptor Ligand Palosuran Family 4 4
Kinesin-like protein KIF11 Inhibitor 9h-carbazole-2-carbaldehy... 1 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Metabotropic glutamate receptor 5 Ligand 1-(3-(2-methylquinoli... 2 12
Metabotropic glutamate receptor 1 Ligand N-(2-phenylpropyl)qui... 3 1
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Acetylcholinesterase Inhibitor Infractopicrin Family 1 1
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
Tubulin beta chain Inhibitor 2-m-tolyl-1h-[1,8]naphthyridin-4-... 5 2
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Histone deacetylase Inhibitor ST-5732 Family 8 6
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Cycl... 7 6
Substance-K receptor ligand 1-N,2-N-bis[2-(1H-indol-3-yl)ethyl... 1 0
Substance-P receptor ligand AGN-PC-01ZIXQ family 13 42
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Huntingtin and Glycogen synthase kinase-3 beta inhibitor SB 21... 2 4
C-C chemokine receptor type 5 ligand AC1LAJEM family 4 14
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 3 7
Rho-associated protein kinase 2 and cAMP-dependent protein kin... 2 7
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 17 14
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 1 13
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 2 1
Cathepsin K inhibitor [(3S)-1-(1H-indole-6-carbonyl)-4,4-dimet... 2 4
Vasopressin V2 receptor and Vasopressin V1a receptor ligand [2... 2 5
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-[4... 4 0
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Glycogen synthase kinase-3 beta inhibitor AGN-PC-07ZA4D family 1 0
Prolyl endopeptidase inhibitor [(2S,3aS,7aS)-2-(pyrrole-1-carb... 2 0
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 1 10
Histone deacetylase 3 and Histone deacetylase 6 inhibitor Tria... 20 37
Mitogen-activated protein kinase 14 and Mast/stem cell growth ... 4 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 1 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 4
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 3 28
Cholecystokinin receptor type A ligand A-65186 family 2 6
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 5 0
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 14 8
Cathepsin L1 inhibitor Bio2_000267 family 9 1
Sodium-dependent serotonin transporter and D(2) dopamine recep... 13 2
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 0
ALK tyrosine kinase receptor ligand SureCN1600195 family 1 1
Vascular endothelial growth factor receptor 2 and Receptor-typ... 7 4
Neuropeptide Y receptor type 5 ligand 2-[4-(benzenesulfonamido... 2 27
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745NK family 2 6
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 13
Smoothened homolog inhibitor SureCN1091571 family 2 2
Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0
Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... 2 0
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 1 0
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Histamine H3 receptor and Cytochrome P450 3A4 ligand AGN-PC-08... 15 5
Vasopressin V1b receptor ligand 2-[3-(3-chlorophenyl)-1-oxo-7-... 2 12
Disintegrin and metalloproteinase domain-containing protein 17... 2 11
Prothrombin and Cationic trypsin inhibitor tert-butyl N-[(2R)-... 4 3
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... 6 0
Renin inhibitor SureCN1144364 family 3 15
Serine/threonine-protein kinase pim-3 and Serine/threonine-pro... 4 6
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M8RE fa... 6 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07PRSG fa... 6 0
Serine/threonine-protein kinase mTOR and DNA-dependent protein... 6 7
Neuronal acetylcholine receptor subunit alpha-7 and Acetylchol... 2 3
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 4 21
Coagulation factor X inhibitor 1-amino-N-[(1R)-2-[4-(4-fluoro-... 2 7
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Renin inhibitor [(2S,4S,5S,7R)-4-amino-8-(butylamino)-5-hydrox... 3 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 19
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 13 1
Cathepsin K inhibitor SureCN2155973 family 3 1
Cruzipain and Cathepsin F inhibitor SureCN12999199 family 2 1
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... 3 0
Gonadotropin-releasing hormone receptor ligand AGN-PC-075KV1 f... 4 1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Cellular tumor antigen p53 and Ferritin light chain inhibitor ... 1 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 1
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 5 2
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
C-C chemokine receptor type 5 ligand AC1LA259 family 1 1
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 0
C-C chemokine receptor type 5 and Muscarinic acetylcholine rec... 3 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
Prelamin-A/C and Tyrosyl-DNA phosphodiesterase 1 inhibitor nif... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 1
Prothrombin and Trypsin-1 inhibitor SureCN12636557 family 9 1
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Disintegrin and metalloproteinase domain-containing protein 17... 3 3
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Somatostatin receptor type 2 ligand (2R,3S)-N-[(5-amino-1,3-di... 2 5
Prelamin-A/C and Pyruvate kinase PKM inhibitor CHEMBL1481187 f... 1 7
Mitogen-activated protein kinase 1 and Nonstructural protein 1... 1 33
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 4
Peptide deformylase inhibitor (2R)-N-[(2S)-3,3-dimethyl-1-oxo-... 2 1
Platelet-activating factor receptor ligand YM-461 family 1 11
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 10 9
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
C-C chemokine receptor type 1 ligand N-[(2S,3S,5R)-5-carbamoyl... 10 4
Metabotropic glutamate receptor 2 and Metabotropic glutamate r... 5 3
Metabotropic glutamate receptor 2 ligand AGN-PC-00A1HD family 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 1
Serine/threonine-protein kinase D3 and Protein kinase C delta ... 3 0
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Dipeptidyl peptidase 4 inhibitor (2S)-1-[2-[5-(aminomethyl)-2-... 4 4
Metabotropic glutamate receptor 1 ligand GTPL6334 family 6 4
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Glycogen synthase kinase-3 beta and Tyrosine-protein kinase JA... 1 0
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Pol polyprotein inhibitor (2S,4S,5S)-5-acetamido-6-cyclohexyl-... 3 3
Glucocorticoid receptor ligand N-ethyl-2-fluoro-N-[3,3,3-trifl... 16 7
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04SK7R family 3 3
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Prothrombin inhibitor AGN-PC-09QKE4 family 1 0
Neuromedin-K receptor ligand 3-methylsulfinyl-N-[(1S)-1-phenyl... 3 5
Substance-K receptor ligand N-[1-[[(2S)-1-[[1-(oxan-4-ylmethyl... 3 0
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Prostaglandin E synthase inhibitor AGN-PC-09QHBK family 3 1
Gonadotropin-releasing hormone receptor and Cytochrome P450 3A... 5 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 2-... 18 2
Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... 3 1
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
ALK tyrosine kinase receptor and Insulin receptor ligand 9-eth... 9 8
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... 4 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4S,... 5 2
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
Hepatocyte growth factor receptor ligand AGN-PC-08XYH0 family 8 4
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SVV family 2 12
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
Histamine H3 receptor ligand SureCN1857507 family 1 4
C-C chemokine receptor type 3 and Probable C-C chemokine recep... 2 4
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 3 5
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
Renin inhibitor (3R,4S)-N-cyclopropyl-N-[[2-(3-methoxypropyl)q... 2 0
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801305 ... 2 0
Mitogen-activated protein kinase 9 and MAP kinase-activated pr... 1 0
C-X-C chemokine receptor type 3 ligand (6aR,9R)-N-phenyl-4-(2-... 5 0
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
B1 bradykinin receptor ligand AGN-PC-005XAO family 3 17
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 4 11
B1 bradykinin receptor ligand 6-(8-fluoro-4-methyl-1-oxophthal... 3 0
B1 bradykinin receptor ligand 5-(8-chloro-4-methyl-1-oxophthal... 1 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Histamine H3 receptor ligand N-methyl-N-[(3R)-1-propan-2-ylpyr... 3 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL186461 family 2 4
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 12
Neuronal acetylcholine receptor subunit alpha-7 ligand AGN-PC-... 7 1
Cytochrome P450 2D6 and Cytochrome P450 2C19 inhibitor Demethy... 1 4
CGMP-dependent protein kinase inhibitor AGN-PC-075XII family 25 7
Renin and Potassium voltage-gated channel subfamily H member 2... 13 11
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 7 0
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL1935258 family 7 2
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 8 5
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Delta-type opioid receptor and Potassium voltage-gated channel... 2 0
Cathepsin L1 and Cathepsin S inhibitor N-[(2S)-4-methyl-1-oxo-... 3 3
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 3 2
Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... 3 8
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 14 1
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
Cathepsin L1 and Cathepsin S inhibitor N-[(2S)-4-methyl-1-oxo-... 2 4
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 7 1
Serine/threonine-protein kinase PLK1 and MAP kinase-activated ... 1 2
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 5
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
5-hydroxytryptamine receptor 3A ligand 3-methyl-N-[7-[[3-methy... 2 0
Adenosine receptor A2b and Adenosine receptor A2a ligand N-(4-... 2 14
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Dipeptidyl peptidase 4 inhibitor 2-[[2-[(3R)-3-aminopiperidin-... 1 0
Calcitonin gene-related peptide type 1 receptor ligand 3-[1-[4... 5 3
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 5 3
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Cannabinoid receptor 1 ligand N-[2-(cyclopropylamino)-2-oxoeth... 5 5
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 9 5
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 1 0
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 1 1
Hematopoietic prostaglandin D synthase inhibitor 4-(3-methylis... 1 7
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Egl nine homolog 1 inhibitor 2-[5-methyl-6-[[1-oxo-2-(4-phenyl... 4 3
B1 bradykinin receptor ligand methyl 2-fluoro-6-[3-fluoro-4-[[... 22 11
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-4-ylpi... 5 8
Poly [ADP-ribose] polymerase 1 inhibitor 8-[[4-fluoro-3-(4-pyr... 5 2
Substance-P receptor ligand Netupitant family 5 2
Prothrombin and Tissue-type plasminogen activator inhibitor 2-... 4 5
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 2 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 2 0
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Melanin-concentrating hormone receptor 1 ligand N-[(3S)-1-[[(3... 2 0
Histamine H1 receptor and Alpha-1B adrenergic receptor ligand ... 8 1
Microsomal triglyceride transfer protein large subunit inhibit... 13 0
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Smoothened homolog inhibitor 3-pyridin-3-yl-N-[1-[[6-[4-[(3-py... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
ALK tyrosine kinase receptor ligand N-[6-[[4-(2-hydroxypropan-... 2 0
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 2 11
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Neuromedin-K receptor and Potassium voltage-gated channel subf... 13 2
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 3 2
Vascular endothelial growth factor receptor 2 and Angiopoietin... 14 0
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Cathepsin S inhibitor N-[(S)-[1-(1-cyanocyclopropyl)triazol-4-... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 6 0
Serine/threonine-protein kinase Chk1 inhibitor 3-[5-(piperidin... 1 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
Coagulation factor X and Prothrombin inhibitor SureCN5819494 f... 5 8
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Cannabinoid receptor 1 ligand N-(cyclobutylmethyl)-3-[[4-(meth... 1 1
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand N-(oxan-... 2 0
Cannabinoid receptor 1 ligand N-(cyclobutylmethyl)-3-[[4-(tria... 1 0
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 2 0
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Fatty-acid amide hydrolase 1 inhibitor 1-[3-[4-(6-phenylhexyl)... 1 0
G-protein coupled bile acid receptor 1 ligand 2-(ethylamino)-6... 5 4
Integrin alpha-V and Integrin beta-6 inhibitor 3-[[2-[4-[(4-me... 4 3
Seprase and Prolyl endopeptidase inhibitor [(2R)-1-[(2R)-2-[(2... 4 2
Neutrophil elastase inhibitor N-[(2S)-3-methyl-1-oxo-1-[(2S)-2... 4 4
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 3
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 1
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 3 4
Beta-secretase 1 inhibitor N-[3-[(4R,5R,6S)-2-amino-5-fluoro-4... 4 11
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Gonadotropin-releasing hormone receptor ligand 6-[(4-chloro-2-... 3 3
Motilin receptor ligand SureCN2768052 family 3 0
Coagulation factor X inhibitor ethyl (3R,4S)-3-[(3-chloro-1H-i... 5 0
C-C chemokine receptor type 2 ligand 2-[4-(5-amino-1H-indol-3-... 3 2
Tankyrase-1 inhibitor N-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1... 3 2
Seprase and Prolyl endopeptidase inhibitor 7-chloro-N-[2-[(2S)... 3 3
Beta-secretase 1 and Beta-secretase 2 inhibitor SureCN14726714... 4 1
Prostaglandin D2 receptor 2 ligand 2-[3-[(E)-2-cyano-3-(N-meth... 9 9
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Acetylcholinesterase inhibitor N-[6-[4-[(6-chloro-1,2,3,4-tetr... 9 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 1
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 4 0
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 4 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(3-fluo... 6 4
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 7 7
Calcitonin gene-related peptide type 1 receptor ligand (2R)-5-... 1 0
Metabotropic glutamate receptor 5 ligand AGN-PC-09SALK family 2 15
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 7 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 2 1
Cathepsin K inhibitor AGN-PC-046RTV family 4 1
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 6-(b... 5 5
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 18
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 5
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 8
C-C chemokine receptor type 2 ligand SureCN5947024 family 11 0
Metabotropic glutamate receptor 1 ligand 4-[1-(2-fluoropyridin... 1 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 1 2
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 1
Hepatocyte growth factor receptor and Protein-tyrosine kinase ... 2 15
Proteinase-activated receptor 1 and Prothrombin ligand (2S)-N-... 3 23
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 3 0
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Substance-P receptor ligand AGN-PC-004REJ family 3 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 4 1
Cannabinoid receptor 1 ligand AGN-PC-07R6QU family 4 2
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Platelet-activating factor receptor ligand N,N-diethyl-3-[(4R)... 11 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 2
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 1
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Cyclin-dependent kinase 2 inhibitor SureCN6589205 family 2 2
Substance-K receptor and Substance-P receptor ligand 3,5-dichl... 3 0
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 6 4
Stromelysin-3 and Neutrophil collagenase inhibitor AGN-PC-074N... 3 1
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand (7S)-... 2 19
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Alpha-1B adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
Histone deacetylase 1 inhibitor AGN-PC-0456JP family 1 0
Gonadotropin-releasing hormone receptor ligand methyl 4-[2-[[(... 2 1
Platelet-activating factor receptor ligand SureCN9852997 family 1 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 0
Coagulation factor X inhibitor AGN-PC-078Y0T family 11 0
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 5 2
Neuromedin-K receptor ligand SureCN3894466 family 1 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 1 0
KiSS-1 receptor ligand SureCN5132924 family 2 4
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[4-oxo-3-(4-p... 2 1
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 0
72 kDa type IV collagenase and Interstitial collagenase inhibi... 1 1
KiSS-1 receptor ligand N-[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-... 1 0
Coagulation factor X and Prothrombin inhibitor N,1-bis[(3-carb... 1 1
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor SureCN4998361 family 1 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Somatostatin receptor type 4 and Somatostatin receptor type 5 ... 3 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Cytochrome P450 2C9 inhibitor AGN-PC-04XDND family 1 3
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
Dipeptidyl peptidase 4 inhibitor SureCN5777667 family 1 4
Beta-secretase 1 and Beta-secretase 2 inhibitor SureCN4964150 ... 3 0
P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin... 3 3
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor Piperazine analogue, ... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
P2X purinoceptor 7 inhibitor N'-quinolin-5-yladamantane-1-carb... 2 9
Mitogen-activated protein kinase 14 inhibitor SureCN14185127 f... 2 0
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 2 2
Histamine H3 receptor ligand SureCN3542210 family 1 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 1
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[4-[3-(dimethylamino)... 106 49
Melanin-concentrating hormone receptor 1 ligand SureCN4917950 ... 3 5
D(3) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 2 0
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
P2Y purinoceptor 12 inhibitor (4S)-4-[(4,6-diphenylpyridine-2-... 1 0
Metabotropic glutamate receptor 1 ligand AGN-PC-07CPMZ family 1 0
P2Y purinoceptor 12 inhibitor pentyl 4-[(2S)-5-[(2-methylpropa... 18 0
Poly [ADP-ribose] polymerase 1 inhibitor SureCN3553433 family 22 0
Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethy... 9 1
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-3-[4-[4-[[... 2 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R6UP family 2 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R9GP family 5 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 2 0
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 1 3
C-X-C chemokine receptor type 3 ligand AGN-PC-07ZH3V family 1 1
Heat shock protein HSP 90-alpha inhibitor CHEMBL1760611 family 19 25
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801315 ... 1 0
Prolyl endopeptidase inhibitor 4-phenyl-1-[(2S,4S)-4-(4-pyridi... 2 1
Bifunctional epoxide hydrolase 2 inhibitor 1-(2,4-dimethylphen... 2 0
Methionine aminopeptidase 1 inhibitor ethyl 4-[4-(2-pyridin-2-... 2 3
Histone deacetylase 6 and Histone deacetylase 8 inhibitor N-hy... 1 0
Acetylcholinesterase inhibitor CHEMBL267591 family 5 0
Metabotropic glutamate receptor 5 ligand 3-methyl-1-[2-[3-(tri... 3 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
Histamine H3 receptor ligand Conessine analogue, 12e family 1 6
Coagulation factor X inhibitor (3R,4R)-3-N-[2-fluoro-4-(2-oxop... 1 0
Trypsin-1 and Coagulation factor X inhibitor 3-[5-(4-carbamimi... 1 0
Muscarinic acetylcholine receptor M2 ligand 2-[3-[(E)-[1-[6-[4... 5 0
Protein-glutamine gamma-glutamyltransferase 2 inhibitor SureCN... 2 2
Vesicular acetylcholine transporter and Sigma non-opioid intra... 2 0
Cytochrome P450 2C19 and Cytochrome P450 3A4 inhibitor (E)-3-[... 4 0
Histone deacetylase 1 inhibitor N-[(2S)-1,8-dioxo-1-[2-(2-phen... 2 0
Tyrosine-protein kinase JAK3 inhibitor (3Z)-5-pyridin-3-yl-3-(... 1 0
Cyclin-dependent kinase 2 inhibitor pyrrollylactam indolinone ... 1 0
Proto-oncogene Wnt-3 inhibitor CHEMBL563202 family 2 0
3-[(3S)-2,5-dioxo-3,4-dihydro-1H-1,4-benzodiazepin-3-yl]-N-pyr... 1 0
2,3,6,7-tetrahydropyrazino[1',2':1,2]pyrido[3,4-b]indole-1,4(1... 3 0
9H-pyrido[3,4-b]indole-3-carboxamide NP (1-(3-bromophenyl)-9h-... 5 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00175748 CHEMBL185687 Bioactive AGN-PC-075GBE
CFAMM00175808 CHEMBL465925 Bioactive SureCN4699580
CFAMM00175821 CHEMBL465917 Bioactive [4-(3,4-difluoroanilino)piperidin-1-yl]-[3-[4-[[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]pyridin-2-yl]methanone
CFAMM00175769 CHEMBL518229 Bioactive [3-[4-[[(3S,5R)-3,5-dimethylpiperazin-1-yl]methyl]-3-fluorophenyl]pyridin-2-yl]-[4-(4-fluoroanilino)piperidin-1-yl]methanone
CFAMM00175767 CHEMBL2348329 Bioactive 2-(2-fluoroanilino)-1-[(2S)-2-(2-fluorophenyl)pyrrolidin-1-yl]-2-(4-pyridin-3-ylphenyl)ethanone
CFAMM00175707 CHEMBL463881 Bioactive [3-[4-[[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]pyridin-2-yl]-[4-(3-fluoroanilino)piperidin-1-yl]methanone
CFAMM00175818 CHEMBL2364307 Bioactive SureCN2766773
CFAMM00175782 CHEMBL465094 Bioactive [3-[4-[[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl]-3-fluorophenyl]pyridin-2-yl]-[4-(3-fluoroanilino)piperidin-1-yl]methanone
CFAMM00175797 CHEMBL2364326 Bioactive SureCN5123409
CFAMM00175817 CHEMBL2364306 Bioactive SureCN2765501
CFAMM00175756 CHEMBL1824642 Bioactive [2-[(3-fluoro-2-methylphenyl)methyl]-1-phenylpyrrolo[3,2-c]pyridin-3-yl]-piperazin-1-ylmethanone
CFAMM00175721 CHEMBL1081612 Bioactive [(2S)-4-[3-fluoro-4-(2-methylphenyl)benzoyl]-2-methylpiperazin-1-yl]-(1H-indol-6-yl)methanone
CFAMM00175749 CHEMBL126366 Bioactive N,N-diethyl-4-[isoquinolin-5-yl(piperazin-1-yl)methyl]benzamide
CFAMM00175833 DPR000120 Investigative Drug YM-344031

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

22920 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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