CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3807
Family Name Delta-type opioid receptor and Mu-type opioid receptor Ligand H-dmt-tic-nh-ch2-imid Family
No. of Seeds 13 No. of Other Members 15
Family Centroid CFAMM00298007 Functional Category Investigative Drug with Natural Product
Superfamily Mu-type opioid receptor and Delta-type opioid receptor Binder Superfamily 3
Class Class 2341

Cousin Family NamesSeedsMembers
Leutinizing-hormone-releasing hormone inhibitor peptide Leupro... 43 911
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Epidermal Growth Factor family 111 209
Histamine H1 receptor Ligand Astemizole Family 7 240
Insulin receptor Ligand Insulin, Porcine Family 61 205
Insulin-degrading enzyme inhibitor cyclic polypeptide Bacitrac... 30 259
Gastrin/cholecystokinin type B receptor ligand oligopeptide Ce... 35 209
Renin Inhibitor Remikiren Family 100 126
Histamine H1 receptor Ligand Mizolastine Family 14 603
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
AEZS-108 family 5 2
Eluxadoline family 4 85
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
Putative histidine protein kinase Inhibitor Closantel 6 Family 1 2
Renin Inhibitor Enalkiren Family 56 44
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
Tyrosine kinase Inhibitor PKI166 Family 17 198
Renin Inhibitor (h-261)boc-his-pro-phe-his-leu(oh)-val-ile-his... 33 41
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-his-agly-ile-v... 3 2
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Oestrogen receptor and Estrogen receptor beta Ligand 4-(2-phen... 2 9
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Delta-type opioid receptor and Gastrin/cholecystokinin type B ... 19 0
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 50 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 36 15
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Indoleamine 2,3-dioxygenase 1 Inhibitor 2-(1h-imidazol-4-yl)be... 2 6
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 0
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 46 0
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
Prothrombin inhibitor SureCN5856722 family 3 16
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Serine/threonine-protein kinase B-raf inhibitor 3-[7-[4-[[(3R)... 6 7
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Proto-oncogene tyrosine-protein kinase Src and Cyclin-dependen... 2 1
Adenosine receptor A1 and Adenosine receptor A2b ligand 3-meth... 7 19
Integrin beta-3 and Integrin alpha-V inhibitor 2-[1-[2-[[4-(1H... 6 2
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 5 0
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Adenosine receptor A3 and Adenosine receptor A2a ligand 4-(5-b... 2 5
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Pol polyprotein inhibitor propan-2-yl N-[(2S)-1-[[(2S,3S,5R)-3... 6 2
Histone deacetylase inhibitor (3S,6S,9S,12R)-3-[(2S)-butan-2-y... 1 0
Hepatocyte growth factor receptor ligand 4-[(6-phenyl-[1,2,4]t... 3 6
Renin inhibitor [2-(5-fluoro-2-methylphenoxy)-5-hydroxy-1-phen... 2 0
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 9 4
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 1 6
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 1 3
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Delta-type opioid receptor ligand ethyl N-[3-[(R)-[4-[ethyl(me... 2 6
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Estrogen receptor beta and Estrogen receptor ligand SureCN6442... 1 2
Histamine H3 receptor ligand 1-[4-(1H-imidazol-5-ylmethyl)pipe... 1 2
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Vascular endothelial growth factor receptor 2 and Vascular end... 4 2
Lysine--tRNA ligase inhibitor 4-[[[2-(2-piperazin-1-ylpyridin-... 2 1
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
Coagulation factor VII inhibitor [3-[(5E)-5-(5-carbamimidoyl-1... 3 2
C-C chemokine receptor type 5 ligand AC1MHRXO family 5 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 11 1
Smoothened homolog inhibitor N-[4-methyl-3-(5-phenyl-1H-imidaz... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 1
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Phosphatidylinositol 4-kinase beta inhibitor (4E)-2-fluoro-4-[... 1 3
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
Renin inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-[[(1R,2S)-3-cycl... 3 0
Type-2 angiotensin II receptor and Type-1A angiotensin II rece... 2 24
Purine nucleoside phosphorylase inhibitor SureCN6345422 family 9 11
Neutrophil collagenase and Matrix metalloproteinase-9 inhibito... 1 1
Cationic trypsin and Prothrombin inhibitor 2-ketobenzothiazole... 1 3
Melanocyte-stimulating hormone receptor and Melanocortin recep... 1 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
5-hydroxytryptamine receptor 2B ligand SureCN1299002 family 2 8
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 2 0
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-04WWHE family 2 0
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-04WVYY family 1 0
Serine/threonine-protein kinase mTOR inhibitor 3-(cyclohexylme... 2 1
Calcitonin gene-related peptide type 1 receptor ligand N-[5-(4... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00297996 CHEMBL2371780 Bioactive (2S)-2-[[(3S)-2-[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]amino]-3-(1H-imidazol-5-yl)propanoic acid
CFAMM00298007 DNC013553 Investigative Drug H-Dmt-Tic-NH-CH2-Imid
CFAMM00298006 DNC013554 Investigative Drug H-Dmt-Tic-NH-CH2-ImidPh

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

42891 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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