CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3822
Family Name Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family
No. of Seeds 9 No. of Other Members 23
Family Centroid CFAMM00298185 Functional Category Investigative Drug
Superfamily Tyrosinase and Fatty-acid amide hydrolase 1 Binder Superfamily
Class Class 2658

Cousin Family NamesSeedsMembers
Beta-2 adrenergic receptor Ligand Formoterol Family 16 63
Beta-1 adrenergic receptor Ligand Practolol Family 2 82
Acyl-CoA desaturase Inhibitor Isoxyl Family 5 62
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
C-C chemokine receptor type 1 Ligand BX-471 Family 10 67
Beta-3 adrenergic receptor Ligand Cgp 12177 Family 3 8
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Alpha-1 adrenergic receptor Ligand DC-015 Family 8 25
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
Inosine-5'-monophosphate dehydrogenase Inhibitor VX-148 Family 2 3
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 20
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor Liga... 40 90
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Substance-K receptor Ligand MEN-14933 Family 13 154
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 11 13
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-... 12 44
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Fatty-acid amide hydrolase 1 Inhibitor 2-fluorophenyl 4-(octyl... 15 9
Fatty-acid amide hydrolase 1 Inhibitor Propan-2-one O-4-(hexyl... 12 4
Fatty-acid amide hydrolase 1 Inhibitor Benzaldehyde O-4-ethoxy... 21 4
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Fatty-acid amide hydrolase 1 Inhibitor Phenmedipham Family 2 5
Aromatase Inhibitor 2,3-dimethoxy-4'-amino-trans-stilbene Family 5 12
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 1 0
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
Beta-1 adrenergic receptor ligand 1-[2-[[(2S)-3-(2-cyanophenox... 10 4
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 2
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 6
Beta-1 adrenergic receptor ligand 4-[2-[[(2S)-3-(2-cyano-5-flu... 3 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 2
Peroxisome proliferator-activated receptor gamma and Peroxisom... 2 10
Bifunctional epoxide hydrolase 2 inhibitor SureCN2729784 family 3 9
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
Transient receptor potential cation channel subfamily V member... 3 15
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 3 1
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor SureCN... 2 11
Nuclear receptor ROR-gamma and Menin ligand CHEMBL1432265 family 1 18
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 3
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
Substance-P receptor ligand (2S,4S)-1-N-(3-chlorophenyl)-2-N-[... 5 2
Gastrin/cholecystokinin type B receptor ligand 1-[3-[[2-(3-met... 2 12
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-088O2I family 3 3
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-088O2K family 2 0
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
Carbonic anhydrase 12 and Probable transmembrane carbonic anhy... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 11 4
Gonadotropin-releasing hormone receptor ligand SureCN5756131 f... 5 7
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 16 6
Transient receptor potential cation channel subfamily V member... 1 0
Renin and Cytochrome P450 3A4 inhibitor SureCN6719989 family 2 0
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 4 19
Sphingosine 1-phosphate receptor 1 ligand 2-methoxy-N-[(4-phen... 2 23
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 6 3
Bifunctional epoxide hydrolase 2 inhibitor 1-(1-adamantyl)-3-[... 2 1
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-[(4... 8 4
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-(2-... 5 3
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-[(4... 10 0
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-[(2... 2 0
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-(2,... 2 11
Furin inhibitor phenyl 2-[[(2S)-1-[[(2S)-1-[[(2S)-1-(4-carbami... 2 5
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 1 0
Bifunctional epoxide hydrolase 2 inhibitor SureCN3178516 family 3 1
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
Translocator protein inhibitor CHEMBL2332259 family 2 0
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 8
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 3 0
Histamine H3 receptor and Histamine receptor H3 ligand 1-[4-[3... 2 0
Histamine H3 receptor and Histamine receptor H3 ligand 1-(3,5-... 1 0
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-ethylbutanoyl)... 11 0
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 20 23
Hormone-sensitive lipase inhibitor SureCN7553414 family 1 1
Neuropeptide Y receptor type 5 ligand 3-[4-(4-fluorophenoxy)ph... 4 0
Neuropeptide Y receptor type 5 ligand 1-[1-(4-fluorophenyl)pro... 2 8
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZ6 family 3 6
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-00RZQT family 3 4
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Prostacyclin receptor ligand CAY10441 family 1 0
Histamine H3 receptor ligand AGN-PC-07ZCFA family 1 0
C-C chemokine receptor type 3 ligand SureCN6700764 family 2 2
Histone deacetylase 8 and Histone deacetylase 6 inhibitor (3S)... 4 16
Protein-S-isoprenylcysteine O-methyltransferase inhibitor N-[2... 1 2
DNA polymerase III PolC-type inhibitor 6-(3-ethyl-4-methylanil... 1 0
Adenosine receptor A3 ligand N-(4-methoxyphenyl)-2-oxo-1H-quin... 1 2
Dihydrofolate reductase inhibitor 4-[[4-(4,6-diamino-2,2-dimet... 1 1
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN9818603 f... 2 2
Menin and Histone-lysine N-methyltransferase 2A inhibitor CHEM... 1 0
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 6-[2-... 1 1
Glucagon receptor ligand 2-chloro-N-[[3-chloro-4-(4-chlorophen... 1 7
Acetylcholinesterase and Butyrylcholinesterase inhibitor AGN-P... 3 0
Acyl-CoA:cholesterol acyltransferase inhibitor [2,6-di(propan-... 1 0
Quinazolines Metabolite Dictyoquinazol B Family 2 1
4,4,6-trimethyl-1,3-dihydroimidazo[1,2-a]indol-2-one NP ZINC02... 37 0
N-(4-acetamidophenyl)-2-(2,2-dimethyl-3,4-dihydrochromen-6-yl)... 1 0
Putative NP ZINC04043041 Family 4 1
8,10,10-trimethyl-3,4-dihydro-1H-pyrimido[1,2-a]indol-2-one NP... 14 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00298191 CHEMBL77589 Bioactive AGN-PC-00FM0N
CFAMM00298198 CHEMBL1606928 Bioactive 1-(4-methoxyphenyl)-3-[2-(3-prop-1-en-2-ylphenyl)propan-2-yl]urea
CFAMM00298202 CHEMBL2047837 Bioactive [4-(2,3-dihydro-1-benzofuran-5-ylcarbamoylamino)phenyl] sulfamate
CFAMM00298195 CHEMBL2047826 Bioactive [4-[(4-phenylmethoxyphenyl)carbamoylamino]phenyl] sulfamate
CFAMM00298187 CHEMBL77276 Bioactive 1-[1-(4-methoxyphenyl)propan-2-yl]-1-methyl-3-(4-phenoxyphenyl)urea
CFAMM00298194 CHEMBL2047820 Bioactive [4-[(4-methoxy-2-methylphenyl)carbamoylamino]phenyl] sulfamate
CFAMM00298186 CHEMBL77273 Bioactive 1-methyl-3-(4-phenoxyphenyl)-1-[(2R)-1-phenylpropan-2-yl]urea
CFAMM00298199 CHEMBL77639 Bioactive 1-[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]-1-methyl-3-(4-phenoxyphenyl)urea
CFAMM00298185 DNC013592 Investigative Drug 1-(4-(benzyloxy)phenyl)-3-hydroxyurea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27513 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543