CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3835
Family Name 5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-methylphenyl)propan-2-amine Family
No. of Seeds 14 No. of Other Members 3
Family Centroid CFAMM00298286 Functional Category Investigative Drug
Superfamily 5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-methylphenyl)propan-2-amine Superfamily
Class Class 1226

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha adrenergic receptor ligand catecholamine Phenylephrine F... 4 39
Alpha-1 adrenergic receptor ligand Dextroamphetamine derivativ... 5 29
Beta-2 adrenergic receptor Ligand Bambuterol Family 4 9
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Substance-P receptor Ligand Ezlopitant Family 10 207
D(3) dopamine receptor Ligand U-99194A Family 7 33
Dapoxetine family 3 40
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Extracellular calcium-sensing receptor Ligand Nps 568 Family 5 54
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
5-hydroxytryptamine receptor 2A Ligand Phenethylamine Family 3 25
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 24
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... 4 31
Cannabinoid receptor 1 Ligand N-(3,5-dimethoxyphenethyl)oleami... 5 49
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 11 21
5-hydroxytryptamine receptor 2A Ligand C-(5-bromo-4,7-dimethox... 9 6
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 6
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 10 15
Cytochrome P450 2D6 Inhibitor 4-methylaminomethyl-7-methoxycou... 3 80
Aromatase Inhibitor 2,3,4-trimethoxy-4'-amino-trans-stilbene F... 9 14
Aromatase Inhibitor 2,3-dimethoxy-4'-amino-trans-stilbene Family 5 12
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Tubulin beta chain Inhibitor Colchinol Family 3 109
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 3 10
5-hydroxytryptamine receptor 2A Ligand (s)-(-)-(4,5,6-trimetho... 3 1
Fatty-acid amide hydrolase 1 Inhibitor 8-phenyloctylcarbamic A... 12 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 2
Sigma non-opioid intracellular receptor 1 ligand 1-[4-(4-metho... 1 0
D(3) dopamine receptor ligand S 14297 family 1 2
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Kinesin-like protein KIF11 inhibitor 2-amino-5-(4-methoxypheny... 1 4
5-hydroxytryptamine receptor 7 and Alpha-2C adrenergic recepto... 3 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 3
Substance-P receptor ligand (5S,10S)-5-(4-fluorophenyl)-10-(2-... 3 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 11
5-hydroxytryptamine receptor 2A ligand methyl 3-[4-[(2R)-2-ami... 1 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Membrane primary amine oxidase inhibitor 2-hydrazinyl-1-(4-met... 1 2
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 4 3
5-hydroxytryptamine receptor 1A ligand (Z)-1-diazonio-3-[[7-(d... 1 1
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-006SR... 1 2
Amine oxidase [flavin-containing] A inhibitor AGN-PC-054NIM fa... 1 0
Amine oxidase [flavin-containing] A inhibitor 1-(4-ethylsulfan... 1 1
Trace amine-associated receptor 1 ligand 4-[4-(2-AMINO-ETHYL)-... 1 0
Tubulin alpha-1A chain inhibitor 1,2,3-trimethoxy-4-[(6R)-6-ni... 1 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 0
Putative NP ZINC00050501 Family 6 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00298282 CHEMBL1204134 Bioactive 1-[2,5-dimethoxy-4-(3-phenylpropyl)phenyl]propan-2-amine;hydrochloride
CFAMM00298274 CHEMBL268890 Bioactive 1-(4-hexyl-2,5-dimethoxyphenyl)propan-2-amine
CFAMM00298279 CHEMBL120116 Bioactive 1-[4-[(2S)-butan-2-yl]-2,5-dimethoxyphenyl]propan-2-amine
CFAMM00298278 CHEMBL1204088 Bioactive 1-(2,5-dimethoxy-4-octylphenyl)propan-2-amine;hydrochloride
CFAMM00298285 CHEMBL418994 Bioactive 1-[2,5-dimethoxy-4-(4-phenylbutyl)phenyl]propan-2-amine
CFAMM00298277 CHEMBL1204089 Bioactive 1-(4-benzyl-2,5-dimethoxyphenyl)propan-2-amine;hydrochloride
CFAMM00298283 CHEMBL1204133 Bioactive 1-(4-hexyl-2,5-dimethoxyphenyl)propan-2-amine;hydrochloride
CFAMM00298276 CHEMBL119924 Bioactive 1-[4-[(2R)-butan-2-yl]-2,5-dimethoxyphenyl]propan-2-amine
CFAMM00298286 DNC013657 Investigative Drug 1-(2,6-dimethoxy-4-methylphenyl)propan-2-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27430 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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