CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3842
Family Name Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3-yl Acetate Family
No. of Seeds 8 No. of Other Members 46
Family Centroid CFAMM00298372 Functional Category Investigative Drug with Natural Product
Superfamily Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3-yl Acetate Superfamily
Class Class 2449

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Acetylcholinesterase Inhibitor Pyridostigmine Family 5 197
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Histamine H1 receptor Ligand Doxylamine Family 2 91
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
DNA Binder Elliptinium Acetate Family 11 116
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Multidrug resistance protein 3 Inhibitor LY335979 Family 1 3
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Neuronal acetylcholine receptor subunit alpha-4 Ligand Isproni... 49 172
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 31
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Apricoxib family 8 77
Indeglitazar family 3 39
Grt 6005/06 family 4 22
PF-02545920 family 16 140
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Dihydroorotate dehydrogenase Inhibitor LY214352 Family 2 17
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Melanin-concentrating hormone receptor 1 Ligand 8-sec-butoxy-q... 30 39
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
Glycogen synthase kinase-3 beta Inhibitor 9-n-ethyl-8-ethoxy-m... 3 0
Squalene synthase Inhibitor ER-119884 Family 2 3
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Indoleamine 2,3-dioxygenase 1 Inhibitor 5-aminoquinolin-8-ol F... 3 16
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
Progesterone receptor Ligand PF-02367982 Family 2 8
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-m... 2 12
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Translocator protein Inhibitor 4-methoxy-5-phenyl-6-thia-10b-a... 7 32
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methyl... 7 27
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Neuronal acetylcholine receptor subunit beta-2 Ligand ABT-594 ... 4 5
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Translocator protein inhibitor SureCN13502542 family 20 2
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YQD... 1 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 1
Sigma non-opioid intracellular receptor 1 ligand 1'-butyl-6-me... 23 0
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 5
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 7 13
Smoothened homolog inhibitor AGN-PC-088VBV family 1 2
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Neuropeptide Y receptor type 1 ligand SureCN7959923 family 1 6
5-hydroxytryptamine receptor 2A and Alpha-1A adrenergic recept... 4 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 9 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
5-hydroxytryptamine receptor 6 ligand SureCN5502542 family 4 2
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Translocator protein inhibitor (4-chloro-6-phenylpyrrolo[2,1-d... 2 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 15
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
Reverse transcriptase/RNaseH inhibitor AC1L9TRY family 1 7
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Coagulation factor X and Anionic trypsin-2 inhibitor AGN-PC-07... 1 1
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL15681... 1 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 7
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Progesterone receptor and Androgen receptor ligand AGN-PC-04QD... 1 0
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 9 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Retinoic acid receptor RXR-alpha ligand (E)-3-[3-(3,5-ditert-b... 5 5
Sigma non-opioid intracellular receptor 1 ligand 6-methoxy-1'-... 2 0
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 2 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
Sodium-dependent serotonin transporter inhibitor SureCN6575591... 2 0
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 3
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2489170 f... 8 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
Prostaglandin D2 receptor 2 ligand 2-[3-(4-chlorophenoxy)-5-fl... 3 3
Corticotropin-releasing factor receptor 1 ligand 2-(2-ethyl-4,... 4 9
Sodium-dependent serotonin transporter and D(2) dopamine recep... 3 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Integrase inhibitor (Z)-4-[1-[(4-fluorophenyl)methyl]-5-methox... 1 0
Serine/threonine-protein kinase B-raf inhibitor pyrrole-based ... 2 0
RAC-alpha serine/threonine-protein kinase inhibitor N-[(2S)-1-... 2 1
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Sodium-dependent serotonin transporter and Sodium-dependent do... 2 0
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... 6 1
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Translocator protein inhibitor N-methyl-2-(2-oxo-5-pyridin-4-y... 8 15
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 2
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand Piper... 3 14
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 1-... 8 6
Neuronal acetylcholine receptor subunit alpha-7 ligand 5-[6-[[... 1 0
Beta-secretase 1 inhibitor (5S)-3'-(3,4-difluorophenyl)-7'-(2-... 4 0
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 5 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Histamine H3 receptor and D(3) dopamine receptor ligand BODILI... 1 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
P2Y purinoceptor 1 inhibitor 1-(4-tert-butylphenyl)-3-[2-(2-pr... 4 14
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Growth hormone secretagogue receptor type 1 ligand SureCN47965... 3 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 6 4
5-hydroxytryptamine receptor 6 ligand 2-methyl-5-(2-nitropheno... 1 6
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 4 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand 4-[1-... 1 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 3
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Egl nine homolog 1 inhibitor 2-(2-methoxy-4-phenylphenyl)-8-[(... 1 0
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Serine/threonine-protein kinase Chk1 and Aurora kinase B inhib... 14 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 1 2
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[2... 4 4
C5a anaphylatoxin chemotactic receptor 1 ligand 2-(2,6-diethyl... 3 5
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Renin inhibitor SureCN6043852 family 2 0
Renin inhibitor SureCN6042213 family 2 3
D(2) dopamine receptor ligand SureCN10575660 family 1 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 5 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 0
5-hydroxytryptamine receptor 6 ligand 1-[9-(2,5-dimethoxypheny... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
RAC-alpha serine/threonine-protein kinase inhibitor Isoquinoli... 1 0
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 2 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
Oxytocin receptor and Vasopressin V1a receptor ligand 4-methox... 9 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
Protein kinase C theta type and Protein kinase C delta type in... 10 7
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 2
Nociceptin receptor and Mu-type opioid receptor ligand N-[[(1S... 2 3
Bifunctional epoxide hydrolase 2 and Voltage-dependent L-type ... 2 1
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
Inosine-5'-monophosphate dehydrogenase inhibitor 5-[(1R)-1-[1-... 2 9
B2 bradykinin receptor ligand SureCN13145573 family 7 6
B2 bradykinin receptor and Cytochrome P450 3A4 ligand SureCN15... 4 0
Sodium-dependent serotonin transporter and D(2) dopamine recep... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 2
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
Nischarin inhibitor SureCN7810370 family 1 0
RAC-alpha serine/threonine-protein kinase and Rho-associated p... 1 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 6 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
D(4) dopamine receptor ligand AGN-PC-00FE9S family 1 6
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[7-(2-chloropheny... 2 0
Glutamate receptor ionotropic, NMDA 2B and Cytochrome P450 2D6... 2 3
Corticotropin-releasing factor receptor 1 ligand 2-[2,6-dimeth... 9 0
DNA gyrase subunit B and DNA gyrase subunit A inhibitor (1S,2R... 4 6
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 1
Corticotropin-releasing factor receptor 1 ligand N-[(1R,2S)-2-... 3 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Reverse transcriptase/RNaseH inhibitor 6Et-7,9-diMe-PBOA-5thio... 1 1
Acetylcholinesterase and Cholinesterase inhibitor P10358 family 2 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 4
Peroxisome proliferator-activated receptor delta and Peroxisom... 1 2
Muscleblind-like protein 1 and Lysosomal alpha-glucosidase inh... 2 0
Histamine H1 receptor and Histamine H2 receptor ligand AGN-PC-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00298355 CHEMBL326943 Bioactive (6-phenylpyrrolo[2,1-d][1,5]benzoxazepin-7-yl) acetate
CFAMM00298382 CHEMBL157135 Bioactive SureCN6583143
CFAMM00298375 CHEMBL135807 Bioactive (6-phenylpyrrolo[2,1-d][1,5]benzoxazepin-7-yl) 4-methylpiperazine-1-carboxylate
CFAMM00298349 CHEMBL347133 Bioactive SureCN6586865
CFAMM00298372 DNC013681 Investigative Drug 1-(2-morpholinoethyl)-1H-indol-3-yl acetate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27746 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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