CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3848
Family Name Metabotropic glutamate receptor 5 Ligand 5-(2-m-tolylethynyl)pyrimidine Family
No. of Seeds 7 No. of Other Members 49
Family Centroid CFAMM00298516 Functional Category Investigative Drug
Superfamily Metabotropic glutamate receptor 5 Binder Superfamily 4
Class Class 2236

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family 10 145
Transient receptor potential cation channel subfamily V member... 15 457
Reverse transcriptase Inhibitor Dapivirine Family 5 72
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 4 30
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Metabotropic glutamate receptor 5 Ligand 2-(3,5-dichlorophenyl... 2 3
Metabotropic glutamate receptor 5 Ligand 2-(3-bromophenyl)-7-m... 3 1
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 2
Metabotropic glutamate receptor 5 Ligand 5-(2-(3-chlorophenyl)... 2 13
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 3 4
Cathepsin K inhibitor 4-[2,2-dimethylpropyl-[[4-(1,2,4-triazol... 2 1
Cathepsin K and Cathepsin L1 inhibitor 5-[3-(3,4-dihydro-1H-is... 2 0
Cathepsin K inhibitor 4-[2,2-dimethylpropyl-[[4-[3-(4-piperidi... 2 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 14 14
Dihydrofolate reductase inhibitor 5-[(4-bromonaphthalen-1-yl)m... 1 2
Dihydropyrimidine dehydrogenase [NADP(+)] inhibitor 5-[(E)-2-p... 1 0
Sigma non-opioid intracellular receptor 1 and Alpha-1B adrener... 1 4


External ID

Functional Category

Molecule Name

CFAMM00298516 DNC013722 Investigative Drug 5-(2-m-tolylethynyl)pyrimidine
CFAMM00298548 DNC013908 Investigative Drug 5-Biphenyl-4-ylethynyl-pyrimidine
CFAMM00298515 DNC013720 Investigative Drug 2-(phenylethynyl)pyrimidine
CFAMM00298547 DNC013907 Investigative Drug 5-(2-(2,5-dimethylphenyl)ethynyl)pyrimidine
CFAMM00298514 DNC013721 Investigative Drug 2-ethoxy-5-(m-tolylethynyl)pyrimidine
CFAMM00298529 DNC013719 Investigative Drug 2-(m-tolylethynyl)pyrimidine
CFAMM00298503 DNC013910 Investigative Drug 5-(2-(4-fluoro-3-methylphenyl)ethynyl)pyrimidine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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