CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3868
Family Name Fatty-acid amide hydrolase 1 Inhibitor 8-phenyloctylcarbamic Acid Biphenyl-3-yl Ester Family
No. of Seeds 12 No. of Other Members 1
Family Centroid CFAMM00298623 Functional Category Investigative Drug
Superfamily Fatty-acid amide hydrolase 1 Binder Superfamily 4
Class Class 2531

Cousin Family NamesSeedsMembers
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Acetylcholinesterase Inhibitor Rivastigmine Family 2 59
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha-1 adrenergic receptor ligand Dextroamphetamine derivativ... 5 29
Sigma non-opioid intracellular receptor 1 ligand opiate Dextro... 9 33
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Substance-P receptor Ligand Ezlopitant Family 10 207
5-hydroxytryptamine receptor 2A Ligand Pimavanserin Family 4 23
Dapoxetine family 3 40
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Extracellular calcium-sensing receptor Ligand Nps 568 Family 5 54
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... 4 31
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 7
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
Fatty-acid amide hydrolase 1 Inhibitor 3-(trifluoromethyl)phen... 3 0
Fatty-acid amide hydrolase 1 Inhibitor Phenylcarbamic Acid Bip... 3 7
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
Fatty-acid amide hydrolase 1 Inhibitor Adamant-1-ylcarbamic Ac... 1 0
Fatty-acid amide hydrolase 1 Inhibitor 3-(4,5-dihydrooxazol-2-... 6 11
Acetylcholinesterase inhibitor [(3aR,8bS)-3,8b-dimethyl-1,2,3a... 1 27
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Cathepsin K inhibitor [1-(3-methoxyphenyl)-2-methylpropan-2-yl... 2 10
Melatonin receptor type 1A ligand [7-methoxy-1-[2-(propanoylam... 3 0
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 117
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Cholinesterase and Acetylcholinesterase inhibitor AGN-PC-009M2... 1 6
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 7 4
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 1 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 0
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Fatty-acid amide hydrolase 1 inhibitor [4-hydroxy-3-(3-sulfamo... 2 0
Lanosterol synthase and Cycloartenol synthase inhibitor 2-hydr... 1 1
Chymase inhibitor 1,3-bis[(3-methoxyphenyl)methyl]-1,3-diazeti... 3 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-006SR... 1 2
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 0
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-009L5C family 1 0
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 1 1
Toluenes Metabolite Metaxalone Family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00298618 CHEMBL2314108 Bioactive FAAH Inhibitor, 2g
CFAMM00298628 CHEMBL188301 Bioactive [3-(3-hydroxyphenyl)phenyl] N-cyclohexylcarbamate
CFAMM00298617 CHEMBL487534 Bioactive AGN-PC-04T7AO
CFAMM00298615 CHEMBL360405 Bioactive AGN-PC-0094GO
CFAMM00298620 CHEMBL521228 Bioactive AGN-PC-04T78X
CFAMM00298624 DNC013791 Investigative Drug 6-Phenylhexylcarbamic Acid Biphenyl-3-yl Ester
CFAMM00298623 DNC013790 Investigative Drug 8-Phenyloctylcarbamic Acid Biphenyl-3-yl Ester
CFAMM00298627 DNC013798 Investigative Drug Cyclohexylmethylcarbamic Acid Biphenyl-3-yl Ester
CFAMM00298622 DNC013796 Investigative Drug Benzylcarbamic Acid Biphenyl-3-yl Ester
CFAMM00298626 DNC013793 Investigative Drug Indan-2-ylcarbamic Acid Biphenyl-3-yl Ester
CFAMM00298621 DNC013794 Investigative Drug Phenethylcarbamic Acid Biphenyl-3-yl Ester
CFAMM00298625 DNC013792 Investigative Drug 4-Phenylbutylcarbamic Acid Biphenyl-3-yl Ester

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24517 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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