CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3872
Family Name Acetylcholinesterase Inhibitor 6-methyl-4-(4-phenylpiperazin-1-yl)coumarin Family
No. of Seeds 6 No. of Other Members 622
Family Centroid CFAMM00299178 Functional Category Investigative Drug with Natural Product
Superfamily Acetylcholinesterase Binder Superfamily
Class Class 2146

Cousin Family NamesSeedsMembers
D(4) dopamine receptor Ligand PD-165167 Family 2 96
Peptidyl-prolyl cis-trans isomerase A Inhibitor 7-amino-4-meth... 4 59
Mineralocorticoid receptor and Androgen receptor Ligand AL-43 ... 79 235
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Oxytocin receptor and Vasopressin V1a receptor Ligand L-371257... 8 92
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
DNA-dependent protein kinase catalytic subunit Inhibitor 4-mor... 7 54
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Amine oxidase [flavin-containing] B Inhibitor N-methyl-n-pheny... 6 25
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Cytochrome P450 2D6 Inhibitor 4-methylaminomethyl-7-methoxycou... 3 80
Aromatase Inhibitor 2,3,4-trimethoxy-4'-amino-trans-stilbene F... 9 14
Aromatase Inhibitor 3,5-diacetoxy-4'-amino-trans-stilbene Family 1 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
D(4) dopamine receptor and D(2) dopamine receptor ligand 7-[[4... 1 23
Androgen receptor ligand (6R,7R)-6,7-diethyl-4-(trifluoromethy... 15 20
Neuropeptide S receptor and Prelamin-A/C ligand CHEMBL1352632 ... 1 25
Acetylcholinesterase inhibitor trimethyl-(2-methyl-3-propanoyl... 3 2
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 4 65
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-ben... 5 334
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 117
Acetylcholinesterase and Cholinesterase inhibitor [3-[4-(3,4-d... 3 18
Nociceptin receptor and Mu-type opioid receptor ligand SureCN7... 13 22
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 5
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-[(4... 3 53
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-ben... 3 2
Acetylcholinesterase and Butyrylcholinesterase inhibitor [3-[[... 1 65
D(4) dopamine receptor ligand 8-methoxy-3-[(4-nitrophenyl)meth... 1 1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor AGN-PC-007ZS... 3 3
Retinoic acid receptor RXR-gamma and Retinoic acid receptor RX... 3 36
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 3
Beta-secretase 1 inhibitor AGN-PC-00QBHE family 1 0
DNA-dependent protein kinase catalytic subunit inhibitor 5-hyd... 1 7
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 2 6
Pol polyprotein inhibitor AC1L9TLB family 1 0
Trypanothione reductase inhibitor 3-(2-chlorophenothiazin-10-y... 1 0
Progesterone receptor ligand 7-(diethylamino)-6-(4-nitrophenyl... 2 0
Progesterone receptor ligand 6-(4-chlorophenyl)-7-(diethylamin... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 7
Endothelin B receptor and Endothelin-1 receptor ligand AGN-PC-... 3 1
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 1
NP 3-(2-(3,4-dihydroquinolin-1(2h)-yl)-2-oxoethyl)-7,8-dihydro... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00299312 CHEMBL52096 Bioactive 4-methyl-7-[3-(4-phenylpiperazin-1-yl)propoxy]chromen-2-one
CFAMM00298976 CHEMBL120661 Bioactive 3,4-dimethyl-7-[3-(4-phenylpiperazin-1-yl)propoxy]chromen-2-one
CFAMM00299173 DNC013818 Investigative Drug 6-Methyl-4-(4-o-tolylpiperazin-1-yl)coumarin
CFAMM00299178 DNC013817 Investigative Drug 6-Methyl-4-(4-phenylpiperazin-1-yl)coumarin

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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