CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFID3883
Family Name Prolyl endopeptidase Inhibitor SUAM-1221 Family
No. of Seeds 42 No. of Other Members 47
Family Centroid CFAMM00299562 Functional Category Investigative Drug
Superfamily Prolyl endopeptidase Inhibitor SUAM-1221 Superfamily
Class Class 634

Cousin Family NamesSeedsMembers
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Opioid receptor Ligand Methadone Family 3 39
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Penicillin binding protein inhibitor β-lactam aminopenicillin ... 12 359
Sodium channel protein type 5 subunit alpha Ligand Indecainide... 2 41
Sodium channel protein type 5 subunit alpha Ligand Mephenytoin... 5 51
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Diet... 29 276
Tumor necrosis factor Inhibitor Thalidomide Family 3 50
Acetylcholinesterase Inhibitor Ambenonium Family 4 71
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
DNA Binder Procarbazine Family 8 358
Noradrenergic re-uptake Inhibitor Milnacipran Family 7 51
Prothrombin Inhibitor Ximelagatran Family 5 48
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 2 9
Peripheral carotid chemoreceptor Ligand Doxapram Family 4 36
Bacterial outer membrane Inhibitor Polymyxin B Family 17 181
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Dopamine reuptake Inhibitor Amineptine Family 2 5
Motilin receptor Ligand GSK962040 Family 30 457
C-C chemokine receptor type 5 Ligand AZD5672 Family 25 70
Substance-P receptor Ligand Orvepitant Family 11 46
Kappa-type opioid receptor Ligand Asimadoline Family 14 54
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 3
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 2 18
Tumor necrosis factor Inhibitor Talactoferrin Alfa Family 26 131
Substance-P receptor Ligand Vestipitant Family 14 137
Thymosin Beta-4 family 8 30
Bavisant family 9 65
Neuropeptide Y receptor type 1 Ligand BIBO3304 Family 4 69
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Melanocortin receptor 4 Ligand Ro-27-3225 Family 6 52
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Reverse transcriptase Inhibitor 3-benzylamino-5-ethyl-6-methyl... 2 24
Histone deacetylase 1 Inhibitor Chlamydocin Family 2 1
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
72 kDa type IV collagenase Inhibitor Batimastat Family 6 52
Integrin alpha-V and Integrin beta-3 Inhibitor C[rgd-(s)-alpha... 19 95
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Prothrombin Inhibitor Efegatran Family 9 47
Neutrophil elastase Inhibitor FK-706 Family 8 85
Neprilysin Inhibitor Thiorphan Family 41 68
Prothrombin Inhibitor LB30812 Family 12 36
Prothrombin Inhibitor Ppack Family 5 4
Neuromedin-K receptor Ligand Senktide Family 15 22
Prothrombin Inhibitor D-leucyl-n-(3-chlorobenzyl)-l-prolinamid... 18 168
Prothrombin Inhibitor D-leucyl-n-(4-carbamimidoylbenzyl)-l-pro... 13 44
Renin Inhibitor N-methyl-n-(methylbenzyl)formamide Family 2 17
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU83876 F... 3 51
Cathepsin F and Cruzipain Inhibitor Benzoyl-arginine-alanine-m... 49 348
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Bifunctional epoxide hydrolase 2 Inhibitor 1-cyclohexyl-3-phen... 3 12
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Disintegrin and metalloproteinase domain-containing protein 17... 8 7
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 10 52
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 3
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Nociceptin receptor Ligand Fggftgcrkscrk Family 10 0
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(6... 1 12
Beta-secretase 1 Inhibitor Glu-leu-asp-leu-(choh-ch2)-ala-ala-... 15 11
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Tic... 11 31
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
Dipeptidyl peptidase 4 Inhibitor N4-(4-chlorobenzyl)-2,4-diami... 10 22
Melanocortin receptor 4 and Substance-K receptor Ligand Hoo-ph... 3 19
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Substance-P receptor Ligand [sar9,met(o2)11]-sp Family 34 9
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Cytosolic phospholipase A2 Inhibitor Methyl 2-(2-oxo-8-phenylo... 2 3
Integrin alpha-V Inhibitor C[rgdf-(3s)-carboxymorpholine] Family 10 2
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Cathepsin S Inhibitor N-(1-oxobutan-2-yl)-3-(trifluoromethyl)b... 2 10
Aminopeptidase N Inhibitor N1,2-dibenzyl-n3-hydroxymalonamide ... 5 23
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-benza... 3 9
Endothelin-converting enzyme 1 Inhibitor PO3 2-leu-nal-o-3k Fa... 3 26
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 80
Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2... 8 13
Genome polyprotein Inhibitor Acasp-glu-met-glu-cha-cys Family 3 6
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Aminopeptidase N Inhibitor 2-benzyl-n1-hydroxy-n3-(4-phenylbut... 5 3
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 3 10
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand N-(3-... 1 7
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
Prothrombin and Coagulation factor X inhibitor AGN-PC-074UE2 f... 1 0
Pol polyprotein inhibitor penicillin deriv. 49 family 3 19
Substance-P receptor ligand (2S)-N-[(2S)-1-[benzyl(methyl)amin... 5 9
Pol polyprotein inhibitor penicillin deriv. 38 family 1 1
Substance-K receptor ligand (4S)-4-amino-1-[4-(oxan-4-ylmethyl... 1 2
Cathepsin K inhibitor [(3S)-4,4-dimethyl-2-oxo-1-(2-phenylethy... 7 9
Prolyl endopeptidase inhibitor SureCN194654 family 3 4
B2 bradykinin receptor ligand SureCN13864840 family 1 6
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 2 0
Coagulation factor X inhibitor (6S,8aS)-2-benzhydrylsulfonyl-N... 5 5
72 kDa type IV collagenase and Matrilysin inhibitor (2S,3R)-N-... 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 7
C-C chemokine receptor type 5 ligand AC1L9USC family 3 2
Plasminogen and Plasma kallikrein inhibitor CHEMBL2016864 family 9 16
Carboxypeptidase B and Carboxypeptidase B2 inhibitor (2S)-7-am... 3 9
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 4 2
Kappa-type opioid receptor ligand 6-[2-oxo-2-[(2S)-2-(pyrrolid... 6 4
Kappa-type opioid receptor ligand 1-[(2S)-2-(pyrrolidin-1-ylme... 4 0
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor S-(3,3-di... 2 3
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 3 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 5 11
Prothrombin inhibitor (2S)-N-[[2-(aminomethyl)-5-chlorophenyl]... 5 11
Baculoviral IAP repeat-containing protein 2 and Baculoviral IA... 2 2
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4S,5S)-4-(1,3-dih... 3 14
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 5 3
Sodium-dependent dopamine transporter and Transporter inhibito... 4 3
Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 2
Substance-P receptor and Neuromedin-K receptor ligand N-[(3R,4... 2 0
Prothrombin inhibitor SureCN7341151 family 6 7
Oxytocin receptor and Vasopressin V1a receptor ligand L 365209... 6 1
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-2-[... 14 4
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 18
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 6
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 3
Survival motor neuron protein inhibitor CHEMBL1323700 family 1 4
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 1 8
Prothrombin inhibitor (2S)-N-[4-(2-amino-2-iminoethyl)cyclohex... 2 0
Prolyl endopeptidase inhibitor (2R)-1-[(2S)-1-[3-[(2R)-2-acety... 15 9
Prolyl endopeptidase inhibitor 2-hydroxy-1-[(2S)-1-[(2S)-1-[3-... 8 0
Acetylcholinesterase inhibitor 5-benzoyl-2-[2-(1-benzylpiperid... 2 3
Neprilysin inhibitor SureCN489232 family 3 9
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 2
Cathepsin S inhibitor SureCN7062841 family 7 7
Peptide deformylase inhibitor (2R)-N-[(2S)-1-(4-fluorophenyl)-... 4 0
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor N-[(2S)... 1 0
Cathepsin K inhibitor [(3R)-4,4-dimethyl-1-phenylpentan-3-yl] ... 7 7
Cathepsin K and Cathepsin S inhibitor 1-benzyl-3-[(2S)-1-[[cya... 1 0
Neuromedin-K receptor ligand SureCN2477089 family 2 4
Chymase and Chymotrypsinogen A inhibitor tert-butyl N-[(2S)-1-... 2 7
Renin and Cathepsin D inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-... 3 4
Coagulation factor X inhibitor (6S,8aS)-N-[(1-carbamimidoylpip... 6 0
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (2S... 16 24
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 0
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 7 16
Dipeptidyl peptidase 4 inhibitor (3R)-4-[(3R)-3-amino-4-(2,4,5... 6 6
Dipeptidyl peptidase 4 inhibitor (3S)-4-[(3R)-3-amino-4-(2,4,5... 1 1
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... 4 9
Vasopressin V1a receptor ligand (2R)-3-(4-chlorophenyl)-2-[[2-... 6 2
Vasopressin V1a receptor ligand N-[(2R)-3-(4-chlorophenyl)-1-[... 6 0
Dipeptidyl peptidase 8 inhibitor (2S)-2-amino-4-[4-[bis(4-fluo... 2 9
Kappa-type opioid receptor ligand N-methyl-N-[(1S)-2-pyrrolidi... 3 17
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 1 1
Sigma non-opioid intracellular receptor 1 ligand (10aS)-2-(2-p... 1 2
Lysosomal Pro-X carboxypeptidase inhibitor (2S,3S)-2-[(2-amino... 3 3
Sigma non-opioid intracellular receptor 1 ligand 2-(3-bromophe... 5 1
Substance-P receptor ligand (3S,4S)-N-[[3,5-bis(trifluoromethy... 8 9
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 2 1
Dipeptidyl peptidase 4 inhibitor SureCN2709139 family 5 7
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 4 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 9 0
Peptide deformylase inhibitor (2S)-N-benzoyl-1-[(2R)-2-(cyclop... 2 2
Substance-P receptor ligand (3R,4R)-1-(1-acetylpiperidine-4-ca... 9 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (3R... 6 1
NS3 inhibitor SureCN14450642 family 4 7
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 8 4
Dipeptidyl peptidase 4 inhibitor 4-cyano-N-[4-[(2S)-2-cyanopyr... 1 1
Dipeptidyl peptidase 4 inhibitor (2S,3S)-3-amino-4-[(3S)-3-flu... 1 5
C-C chemokine receptor type 2 ligand (2S)-N-[[3,5-bis(trifluor... 1 0
Histamine H3 receptor and Acetylcholinesterase ligand 1-[4-[[4... 1 2
Melanin-concentrating hormone receptor 1 and Cytochrome P450 2... 3 4
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 13 3
Prolyl endopeptidase and Seprase inhibitor [(2R)-1-[2-[(2,5-di... 3 2
Histamine H3 receptor ligand N-ethyl-3-fluoro-3-[3-fluoro-4-(p... 3 0
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-(cyanomethyl)-... 1 0
Prolyl endopeptidase and Seprase inhibitor [(2R)-1-(4-oxo-4-ph... 1 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 4
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 3 0
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 4 0
P2X purinoceptor 7 inhibitor SureCN8516206 family 5 1
P2X purinoceptor 7 inhibitor (4S)-3-methyl-N-[[2-methyl-3-(tri... 3 0
Kappa-type opioid receptor ligand 1-[4-acetyl-2-[[(3S)-3-hydro... 2 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Menin inhibitor CHEMBL2314816 family 2 6
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
Cannabinoid receptor 2 ligand 1-adamantyl(1,3-dihydroisoindol-... 1 0
Receptor activity-modifying protein 1 and Calcitonin gene-rela... 2 4
Cationic trypsin and Prothrombin inhibitor (2S)-N-[(2S)-5-(dia... 2 0
Dipeptidyl peptidase 4 inhibitor 4-[4-[(3S,5S)-5-(1,3-thiazoli... 3 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 3 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 15 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 1
Cationic trypsin and Prothrombin inhibitor (3S,6S)-6-amino-6-b... 4 2
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 7 1
Alpha-1A adrenergic receptor and Histamine H1 receptor ligand ... 13 1
Prolyl endopeptidase inhibitor 1-[(4R)-4-(pyrrolidine-1-carbon... 11 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 3 1
Follicle-stimulating hormone receptor ligand N-[[3-[4-[[(2S,5S... 7 0
Substance-P receptor and Potassium voltage-gated channel subfa... 5 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Mu-type opioid receptor ligand CHEMBL303404 family 1 1
Prolyl endopeptidase inhibitor ethyl 2-oxo-2-[(2S)-1-[(2S)-1-(... 1 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 10 0
Coagulation factor X inhibitor ethyl 2-[[(3S)-3-[[2-[[(2R)-2-(... 4 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor methyl ... 6 2
Prolyl endopeptidase inhibitor [(2S)-2-(pyrrolidine-1-carbonyl... 3 0
Collagenase 3 and Interstitial collagenase inhibitor (4-benzyl... 2 0
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
Prothrombin inhibitor methyl (3S)-3-[[(6S,8aS)-2-benzylsulfony... 5 1
C-C chemokine receptor type 5 ligand 1-[[(3S,4S)-1-(cyclohexyl... 1 0
Prolyl endopeptidase inhibitor SureCN8938628 family 2 0
Pepsin A and Renin inhibitor N-[(3R)-1-[[(1S)-1-hydroxy-3-[[(2... 1 0
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor Su... 1 1
Sigma non-opioid intracellular receptor 1 ligand tert-butyl N-... 1 9
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 1 0
C-C chemokine receptor type 5 ligand N-[1-[(3R)-4-[benzenesulf... 3 1
72 kDa type IV collagenase and Disintegrin and metalloproteina... 1 13
Prolyl endopeptidase and Seprase inhibitor [(2R)-1-[2-[benzoyl... 2 0
Histone deacetylase 1 and Histone deacetylase 8 inhibitor meth... 1 3
Prothrombin inhibitor [(1R)-4-carbamimidoylsulfanyl-1-[[2-[met... 1 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[2-(3-methy... 1 0
Angiotensin-converting enzyme inhibitor SureCN7263641 family 2 11
Melanocortin receptor 4 and Melanocortin receptor 3 ligand (2S... 2 0
Prolyl endopeptidase inhibitor 2-{3-[(2s)-4,4-Difluoro-2-(Pyrr... 2 2
Histamine H3 receptor ligand [(3aR,6aR)-4-[4-[2-[(2R)-2-methyl... 6 0
C-C chemokine receptor type 5 ligand N-benzyl-N-[(3R)-1-[(1S,5... 1 3
Histamine H3 receptor ligand Conessine analogue, 13e family 1 0
Growth hormone-releasing hormone receptor ligand (1S)-1'-[(2R)... 7 4
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor N-... 9 0
Receptor tyrosine-protein kinase erbB-2 and Disintegrin and me... 3 4
Receptor tyrosine-protein kinase erbB-2 and Disintegrin and me... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 6
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Prothrombin inhibitor 1-(2-amino-3,3-diphenylpropanoyl)-N-[(3-... 1 1
Interstitial collagenase and 72 kDa type IV collagenase inhibi... 1 1
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1
Ribonucleoside-diphosphate reductase large subunit and Ribonuc... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Glucose-dependent insulinotropic receptor ligand (1-methylcycl... 4 3
Gamma-secretase subunit PEN-2 inhibitor SureCN5966881 family 1 9
Histone deacetylase 8 and Histone deacetylase 1 inhibitor tert... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor Su... 6 5
Papain and Cathepsin S inhibitor dipeptide-derived nitrile, 28... 1 2
Histamine H3 receptor ligand (2S)-N-(2,3-dihydro-1H-inden-2-yl... 2 1
Peptide deformylase and Peptide deformylase 1A, chloroplastic/... 1 2
P2X purinoceptor 7 inhibitor SureCN2574353 family 1 1
Pdk3 protein and [Pyruvate dehydrogenase (acetyl-transferring)... 3 0
NS3 inhibitor 6-[[(2S)-1-[[(2S)-1-[(2S)-2-[[1-(cyclopropylamin... 2 0
Dipeptidyl peptidase 4 inhibitor SureCN14523901 family 7 1
Dipeptidyl peptidase 4 inhibitor (2S,4S)-4-fluoro-1-[2-[[(E)-2... 1 0
Prolyl endopeptidase inhibitor 3eq9 family 1 0
C5a anaphylatoxin chemotactic receptor 1 ligand SureCN12047569... 1 7
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 1 0
4'-phosphopantetheinyl transferase ffp and Beta-lactamase inhi... 1 0
DNA polymerase beta and Muscleblind-like protein 1 inhibitor C... 1 0
Smoothened homolog inhibitor N-cyclohexyl-1,3-dioxo-2-[(1S,2R)... 2 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (3... 2 0
carboxamide NP (s)-n1-(1-hydrazinyl-1-oxo-3-phenylpropan-2-yl)... 2 0
NP Tert-butyl ((s)-1-oxo-1-((1r,5s)-8-oxo-5,6-dihydro-1h-1,5-m... 1 0
NP (s,e)-3-benzylidenehexahydropyrrolo[1,2-a]pyrazine-1,4-dion... 2 2
4-[[[1-[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-pheny... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00299590 CHEMBL1765235 Bioactive SureCN12658496
CFAMM00299605 CHEMBL63045 Bioactive SureCN8745486
CFAMM00299631 CHEMBL33094 Bioactive (2S)-1-(3,3-dimethyl-2-oxopentanoyl)-N-(3-phenylpropyl)pyrrolidine-2-carboxamide
CFAMM00299582 CHEMBL1087219 Bioactive SureCN8795141
CFAMM00299611 CHEMBL311012 Bioactive SureCN8549466
CFAMM00299604 CHEMBL307793 Bioactive CHEMBL307793
CFAMM00299554 CHEMBL62580 Bioactive SureCN9045240
CFAMM00299617 CHEMBL2178958 Bioactive (2S)-1-[(2S,4S)-4-azido-1-(4-phenylbutanoyl)pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
CFAMM00299630 CHEMBL1086845 Bioactive ACMC-20mgl7
CFAMM00299568 CHEMBL373821 Bioactive 1-[(3R,8aS)-3-benzyl-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-2-phenylethanone
CFAMM00299581 CHEMBL119398 Bioactive 1-[(2S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbonyl]pyrrolidine-2-carbaldehyde
CFAMM00299596 CHEMBL65284 Bioactive (2S)-1-[(2S)-1-[2-[(2S)-1,2,3,4-tetrahydronaphthalen-2-yl]acetyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbaldehyde
CFAMM00299636 CHEMBL2024671 Bioactive (2S)-1-[(2R)-1-(4-phenylbutanoyl)pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
CFAMM00299587 CHEMBL75968 Bioactive [(2S,3aS,7aS)-2-(1,2-oxazolidine-2-carbonyl)-2,3,3a,4,5,6,7,7a-octahydroindol-1-yl]-[(1R,2S)-2-phenylcyclopropyl]methanone
CFAMM00299553 CHEMBL2448354 Bioactive [(1R)-5-amino-1-[[(2S)-1-(3-phenylpropanoyl)pyrrolidine-2-carbonyl]amino]pentyl]boronic acid;hydrochloride
CFAMM00299629 CHEMBL194993 Bioactive SureCN2709317
CFAMM00299567 CHEMBL1088415 Bioactive SureCN8792888
CFAMM00299580 CHEMBL1087606 Bioactive [(2S,3aS,7aS)-2-(2,5-dihydropyrrole-1-carbonyl)-2,3,3a,4,5,6,7,7a-octahydroindol-1-yl]-[(1R,2R)-2-phenylcyclopropyl]methanone
CFAMM00299559 CHEMBL421519 Bioactive [(2S,3aS,7aS)-2-(pyrrolidine-1-carbonyl)-2,3,3a,4,5,6,7,7a-octahydroindol-1-yl]-[(1R,2S)-2-phenylcyclopropyl]methanone
CFAMM00299573 CHEMBL1087103 Bioactive [(2S,3aS,7aS)-2-(1,2-oxazolidine-2-carbonyl)-2,3,3a,4,5,6,7,7a-octahydroindol-1-yl]-[(1R,2R)-2-phenylcyclopropyl]methanone
CFAMM00299602 CHEMBL1160014 Bioactive N-[(4-aminocyclohexyl)methyl]-1-[(2R)-2-(methylamino)-3-phenylpropanoyl]pyrrolidine-2-carboxamide
CFAMM00299615 CHEMBL169572 Bioactive (2S)-1-[(2S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbonyl]pyrrolidine-2-carbaldehyde
CFAMM00299628 CHEMBL80839 Bioactive SureCN8548209
CFAMM00299579 CHEMBL1087605 Bioactive SureCN9182610
CFAMM00299593 CHEMBL79213 Bioactive [(2S,3aS,7aS)-2-(pyrrolidine-1-carbonyl)-2,3,3a,4,5,6,7,7a-octahydroindol-1-yl]-[(1R,2S)-2-(4-methylphenyl)cyclopropyl]methanone
CFAMM00299608 CHEMBL305681 Bioactive [(2S,3aS,7aS)-2-(pyrrolidine-1-carbonyl)-2,3,3a,4,5,6,7,7a-octahydroindol-1-yl]-[(1R,2S)-2-[3-(trifluoromethyl)phenyl]cyclopropyl]methanone
CFAMM00299585 CHEMBL302654 Bioactive (2S)-1-[(2S)-1-[2-(2,3-dihydro-1H-inden-2-yl)acetyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbaldehyde
CFAMM00299564 CHEMBL362971 Bioactive 1-[(2S)-2-[(2S)-2-(2-hydroxyacetyl)pyrrolidine-1-carbonyl]pyrrolidin-1-yl]-4-phenylbutan-1-one
CFAMM00299578 CHEMBL80865 Bioactive [(2S,3aS,7aS)-2-(2,5-dihydropyrrole-1-carbonyl)-2,3,3a,4,5,6,7,7a-octahydroindol-1-yl]-[(1R,2S)-2-phenylcyclopropyl]methanone
CFAMM00299557 CHEMBL189620 Bioactive 4an0
CFAMM00299571 CHEMBL80684 Bioactive [(2S,3aS,7aS)-2-(pyrrolidine-1-carbonyl)-2,3,3a,4,5,6,7,7a-octahydroindol-1-yl]-[(1R,2S)-2-(4-fluorophenyl)cyclopropyl]methanone
CFAMM00299633 CHEMBL1087096 Bioactive 3-cyclohexyl-N-[(2S)-1-oxo-3-phenyl-1-[(2S)-2-(piperidine-1-carbonyl)pyrrolidin-1-yl]propan-2-yl]propanamide
CFAMM00299591 CHEMBL311848 Bioactive [(2S,3aS,7aS)-2-(2,3-dihydropyrrole-1-carbonyl)-2,3,3a,4,5,6,7,7a-octahydroindol-1-yl]-[(1R,2S)-2-phenylcyclopropyl]methanone
CFAMM00299556 CHEMBL375794 Bioactive SureCN5964431
CFAMM00299619 CHEMBL63745 Bioactive SureCN8155749
CFAMM00299570 CHEMBL363655 Bioactive (2S)-1-[(2S)-1-benzoylpyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
CFAMM00299612 CHEMBL308073 Bioactive SureCN9177116
CFAMM00299562 DNC013851 Investigative Drug SUAM-1221

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48712 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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