CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3895
Family Name Metabotropic glutamate receptor 5 Ligand 5-(2-(3-chlorophenyl)ethynyl)pyrimidine Family
No. of Seeds 2 No. of Other Members 13
Family Centroid CFAMM00299850 Functional Category Investigative Drug
Superfamily Metabotropic glutamate receptor 5 Binder Superfamily 4
Class Class 2236

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family 10 145
Transient receptor potential cation channel subfamily V member... 16 295
Reverse transcriptase Inhibitor Dapivirine Family 5 72
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
D(4) dopamine receptor Ligand L-745,870 Family 30 205
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Plasminogen and Tissue-type plasminogen activator Inhibitor N-... 1 5
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 4 30
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Sodium channel protein type 1 subunit alpha and Sodium channel... 1 2
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Macrophage migration inhibitory factor Inhibitor 1-(2-chloroph... 2 22
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Reverse transcriptase Inhibitor PT-109 Family 6 7
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Metabotropic glutamate receptor 5 Ligand 2-(3,5-dichlorophenyl... 2 3
Metabotropic glutamate receptor 5 Ligand 5-(2-m-tolylethynyl)p... 7 49
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Dihydrofolate reductase inhibitor AC1LAKWV family 2 0
Dihydrofolate reductase inhibitor 6-[[(4-chloronaphthalen-1-yl... 2 1
Dipeptidyl peptidase 4 inhibitor Aminomethylpyrimidine 1ck family 6 3
Cell division cycle 7-related protein kinase and Dual specific... 3 1
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 5
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 14 14
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 2
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... 2 0
Dihydrofolate reductase inhibitor 5-[(4-bromonaphthalen-1-yl)m... 1 2
Nitric oxide synthase, inducible inhibitor N-(3-chlorophenyl)-... 1 0
Dihydropyrimidine dehydrogenase [NADP(+)] inhibitor 5-[(E)-2-p... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00299857 CHEMBL21414 Bioactive AGN-PC-042YGR
CFAMM00299850 DNC013911 Investigative Drug 5-(2-(3-chlorophenyl)ethynyl)pyrimidine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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