CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3903
Family Name Sodium-dependent dopamine transporter Inhibitor Secocularidine Family
No. of Seeds 3 No. of Other Members 9
Family Centroid CFAMM00299985 Functional Category Investigative Drug
Superfamily Acetylcholinesterase Inhibitor Galantamine Superfamily
Class Class 332

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand catecholamine Dopamine family 9 170
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Beta adrenergic receptor ligand catecholamine group Isoprotere... 7 130
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Delta-type opioid receptor ligand opiate analog Codeine Family 15 184
u-type opioid receptor ligand opiate analog Buprenorphine Family 78 234
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Beta-2 adrenergic receptor ligand catecholamine Orciprenaline ... 13 13
Beta-2 adrenergic receptor ligand catecholamine Salbutamol Family 10 90
Beta-2 adrenergic receptor Ligand Bambuterol Family 4 9
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Neuronal acetylcholine receptor subunit alpha-2 Ligand Metocur... 18 169
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Serotonin re-uptake Inhibitor Paroxetine Family 6 19
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Tyrosinase Inhibitor Monobenzone Family 6 197
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Oestrogen receptor ligand Dienestrol Family 35 440
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Zucapsacin family 7 177
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Translocator protein Inhibitor Dextofisopam Family 3 250
5-hydroxytryptamine receptor 1A Ligand MN-305 Family 12 26
D(3) dopamine receptor Ligand U-99194A Family 7 33
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Vernakalant family 1 1
Oxi4503 family 4 27
Acolbifene family 10 115
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 2 5
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
Arachidonate 5-lipoxygenase Inhibitor Caffeic Acid Family 3 32
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Peptide deformylase, mitochondrial Inhibitor Tylophorinidine F... 7 1
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
5-hydroxytryptamine receptor 2A Ligand Phenethylamine Family 3 25
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 24
Arachidonate 15-lipoxygenase Inhibitor Isoscopoletin Family 5 98
Platelet-activating factor receptor Ligand L-652731 Family 5 116
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-... 3 9
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 5 13
Tubulin beta chain Inhibitor Combretastatin Family 3 5
Arachidonate 15-lipoxygenase and Arachidonate 5-lipoxygenase I... 3 18
Neutrophil elastase Inhibitor N,n-bis(cyanomethyl)-3,4-dimetho... 3 30
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 2 1
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Beta-secretase 1 Inhibitor Eckol Family 6 40
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
D(1A) dopamine receptor Ligand SCH-12679 Family 1 0
Tubulin beta chain Inhibitor Colchinol Family 3 109
D(2) dopamine receptor and D(1A) dopamine receptor Ligand 3-ch... 2 0
Kappa-type opioid receptor Ligand Morphinan Cyclic Imine Analo... 20 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 7 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 4 10
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 2 2
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 2 2
Transient receptor potential cation channel subfamily V member... 2 6
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 8 4
Mu-type opioid receptor and Sigma non-opioid intracellular rec... 10 20
D(1A) dopamine receptor ligand DOXANTHINE family 3 0
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 2
Alpha-1A adrenergic receptor and 5-hydroxytryptamine receptor ... 1 0
D(1A) dopamine receptor and D(3) dopamine receptor ligand N,N-... 3 1
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 7 4
DNA-(apurinic or apyrimidinic site) lyase and Menin inhibitor ... 1 6
Transient receptor potential cation channel subfamily V member... 14 7
Transient receptor potential cation channel subfamily V member... 1 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
Muscarinic acetylcholine receptor M3 and Beta-2 adrenergic rec... 2 1
Sigma non-opioid intracellular receptor 1 ligand BAS 04057753 ... 5 8
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Histamine H3 receptor ligand SureCN6071181 family 2 1
7-dehydrocholesterol reductase inhibitor 2-[2-(4-chlorophenyl)... 2 3
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
Muscarinic acetylcholine receptor M5 and Muscarinic acetylchol... 1 3
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 22 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
Transient receptor potential cation channel subfamily V member... 4 40
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 7
Putative Bioactive 5-hexyl-2-[4-[(4-methylpiperazin-1-yl)methy... 2 0
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 2 26
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 3 14
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 5
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 10 8
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Sodium-dependent noradrenaline transporter and Cytochrome P450... 11 2
High affinity choline transporter 1 inhibitor 1-[4-(3,4,5-trim... 2 3
Phenols and Derivatives Metabolite 2-Ethoxy-4-(4-methyl-1,3-di... 1 0
NP (z)-n-((4-(3,4-dimethoxyphenyl)tetrahydro-2h-pyran-4-yl)met... 3 2
Putative NP ZINC08453899 Family 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00299972 CHEMBL542785 Bioactive SureCN8203328
CFAMM00299985 DNC013977 Investigative Drug SECOCULARIDINE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27744 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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