CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3926
Family Name Leukotriene A-4 hydrolase Inhibitor SA-6541 Family
No. of Seeds 4 No. of Other Members 32
Family Centroid CFAMM00300177 Functional Category Investigative Drug with Natural Product
Superfamily Leukotriene A-4 hydrolase Inhibitor SA-6541 Superfamily
Class Class 2932

Cousin Family NamesSeedsMembers
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Angiotensin-converting enzyme Inhibitor Benazepril Family 7 123
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Motilin receptor Ligand GSK962040 Family 30 457
Integrin alpha-4 Inhibitor BIO-1211 Family 16 83
Neprilysin Inhibitor Thiorphan Family 41 68
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 18
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Protein kinase C eta type and Protein kinase C delta type Inhi... 9 12
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Amine oxidase [flavin-containing] B Inhibitor L-136662 Family 3 20
Aldose reductase Inhibitor (4-methyl-2-oxo-2h-quinolin-1-yl)-a... 1 15
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
Protein farnesyltransferase subunit beta and Protein farnesylt... 3 5
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(2-a... 2 8
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 6 6
Angiotensin-converting enzyme inhibitor (2S)-1-[(2S)-2-sulfany... 7 23
Pol polyprotein inhibitor Lysine Sulfonamide 11o family 2 6
Mitogen-activated protein kinase 1 and M17 leucyl aminopeptida... 1 21
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
Dipeptidyl peptidase 4 inhibitor SureCN1499864 family 4 7
Stromelysin-1 inhibitor 6-(4'-FLUORO-BIPHENYL-4-YL)-4-(3-METHY... 3 0
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 3 5
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-1-... 3 3
Angiotensin-converting enzyme inhibitor (2S)-2-[[(3R)-5-(carbo... 6 4
Angiotensin-converting enzyme inhibitor AGN-PC-076HUL family 1 0
Sodium channel protein type 9 subunit alpha ligand tert-butyl ... 2 30
fMet-Leu-Phe receptor ligand (2S)-2-[[(2S)-2-[[(2S)-2-[(4-chlo... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 4 2
Growth hormone secretagogue receptor type 1 ligand SureCN77944... 1 2
Granzyme B and Caspase-3 inhibitor CHEMBL304368 family 2 1
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
Caspase-8 and Caspase-3 inhibitor (3S)-3-[[(2S)-4-methyl-2-[[2... 3 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 5
Angiotensin-converting enzyme inhibitor 6-methyl-4-(4-methylph... 1 1
Angiotensin-converting enzyme inhibitor 89177-63-9 family 2 0
Neprilysin and Angiotensin-converting enzyme inhibitor 3-[(3S)... 1 0
Prostaglandin E synthase and DNA-(apurinic or apyrimidinic sit... 1 0
Angiotensin-converting enzyme inhibitor AGN-PC-076I0I family 1 2
Glycogen synthase kinase-3 beta inhibitor NSC690619 family 1 2
Putative NP ZINC08876684 Family 38 1
2-[[(2S)-2-[(3-oxo-2,4-dihydroquinoxaline-1-carbonyl)amino]-3-... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00300185 CHEMBL416979 Bioactive SureCN10345800
CFAMM00300208 CHEMBL415932 Bioactive 2-[(3S)-3-[[(2S)-4-methyl-2-sulfanylpentanoyl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid
CFAMM00300201 CHEMBL160361 Bioactive AGN-PC-00N8FR
CFAMM00300177 DNC014052 Investigative Drug SA-6541

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27059 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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