CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3944
Family Name Fatty-acid amide hydrolase 1 Inhibitor 3-(benzo[d]oxazol-2-yl)phenyl Propylcarbamate Family
No. of Seeds 1 No. of Other Members 6
Family Centroid CFAMM00300322 Functional Category Investigative Drug with Natural Product
Superfamily Neutrophil elastase and Fatty-acid amide hydrolase 1 Binder Superfamily
Class Class 994

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Oxaprozin Family 33 450
Nitric oxide synthase, endothelial Inhibitor Acclaim Family 2 15
Egl nine homolog 2 Inhibitor FG-4592 Family 1 4
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Benoxapr... 1 76
Substance-P receptor Ligand R 673 Family 2 127
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
C-C chemokine receptor type 2 and C-C motif chemokine 2 Ligand... 3 52
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Chymase Inhibitor Y-40613 Family 11 56
Melatonin receptor type 1B Ligand N-(3-benzooxazol-7-yl-propyl... 26 101
Peroxisome proliferator-activated receptor gamma Ligand SB-213... 2 54
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
Fatty-acid amide hydrolase 1 Inhibitor (z)-1-(benzo[d]oxazol-2... 2 27
Oestrogen receptor and Estrogen receptor beta Ligand 2-(6-hydr... 9 22
Prostacyclin receptor and Prostaglandin E2 receptor EP3 subtyp... 4 17
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
Leukotriene A-4 hydrolase Inhibitor 2-[4-(2-azepan-1-ylethoxy)... 5 15
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Peroxisome proliferator-activated receptor alpha Ligand BMS-68... 10 16
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 1 4
Arachidonate 5-lipoxygenase Inhibitor 5-methyl-n-phenylbenzo[d... 5 13
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 4 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 7
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[3-(1,3-be... 3 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 21
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16f ... 3 18
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
5-hydroxytryptamine receptor 3A ligand 2-[(3S)-3-ethylmorpholi... 10 18
5-hydroxytryptamine receptor 3A and Potassium voltage-gated ch... 1 0
Neutrophil elastase inhibitor 1-N-[(2S)-1-[(2S)-2-[[(2S)-1-(1,... 7 1
Neutrophil elastase inhibitor methyl 2-[(2S)-3-methyl-2-[[(2S)... 2 0
Prelamin-A/C inhibitor CHEMBL1374443 family 1 6
Thyroid hormone receptor beta ligand CHEMBL1397256 family 1 12
Pol polyprotein inhibitor (2S)-4-(1,3-benzoxazol-2-ylmethyl)-1... 1 0
Inosine-5'-monophosphate dehydrogenase inhibitor SureCN1318237... 2 12
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 5 12
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 4 1
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 1 1
Peroxisome proliferator-activated receptor gamma and Peroxisom... 4 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and Dual 3',5'... 27 20
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 14 24
Prostaglandin E2 receptor EP4 subtype and Prostaglandin E2 rec... 7 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 3
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
Peroxisome proliferator-activated receptor alpha and Peroxisom... 5 2
Peroxisome proliferator-activated receptor gamma and Peroxisom... 10 5
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 1 1
Peroxisome proliferator-activated receptor gamma and Peroxisom... 3 0
Cathepsin S inhibitor (2S,4R)-4-(benzenesulfonyl)-N-[1-(1,3-be... 4 0
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 1
Cholesteryl ester transfer protein inhibitor 2-(4-chloro-2,3-d... 1 1
Coagulation factor X and Plasma kallikrein inhibitor (2R)-N-[2... 1 0
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 11 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(2,6-di... 2 4
Neutrophil elastase inhibitor methyl 2-[(2S)-2-[[(2S)-1-[(2S)-... 3 0
Cathepsin S and Cathepsin L1 inhibitor (2S)-2-(1,3-benzoxazol-... 1 9
Peroxisome proliferator-activated receptor gamma and Peroxisom... 7 2
Peroxisome proliferator-activated receptor gamma and Peroxisom... 4 3
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15
D(4) dopamine receptor ligand SureCN8704964 family 1 2
Cellular tumor antigen p53 inhibitor CHEMBL1592002 family 1 0
Cholesteryl ester transfer protein inhibitor AGN-PC-09QKST family 1 3
Cholesteryl ester transfer protein inhibitor AGN-PC-09QM3I family 1 9
Reverse transcriptase/RNaseH inhibitor 3-[2-(4,7-difluoro-1,3-... 3 1
Cholesteryl ester transfer protein inhibitor N-[4-(5-chloro-7-... 1 0
Cholesteryl ester transfer protein inhibitor AGN-PC-07R9U4 family 1 1
Arachidonate 5-lipoxygenase inhibitor (4E)-4-[(E,4Z)-4-(3H-1,3... 6 6
Reverse transcriptase/RNaseH inhibitor 3-(1,3-benzoxazol-2-ylm... 1 0
2-enenitrile NP ZINC05025155 Family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00300322 DNC014111 Investigative Drug 3-(benzo[d]oxazol-2-yl)phenyl propylcarbamate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27513 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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