CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3955
Family Name Amine oxidase [flavin-containing] A and Amine oxidase [flavin-containing] B Inhibitor 2-[7-(benzyloxy)-2-oxo-2h-chromen-4-yl]acetamide Family
No. of Seeds 3 No. of Other Members 27
Family Centroid CFAMM00300437 Functional Category Investigative Drug with Natural Product
Superfamily Amine oxidase [flavin-containing] A and Amine oxidase [flavin-containing] B Inhibitor 2-[7-(benzyloxy)-2-oxo-2h-chromen-4-yl]acetamide Superfamily
Class Class 2426

Cousin Family NamesSeedsMembers
Cannabinoid receptor 1 Ligand Marinol Family 32 454
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Cyclooxygenase inhibitor salicylate derivative Aspirin family 3 234
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Heat shock protein 90, putative Inhibitor Cromoglicate Family 14 2827
DNA Binder Methoxsalen Family 10 1638
Muscarinic acetylcholine receptor Ligand Flavoxate Family 9 350
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Ipriflavone family 62 2480
Rotenone family 16 107
Agrimophol family 10 22
Salicin family 5 629
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
Oxi4503 family 4 27
Acolbifene family 10 115
Free fatty acid receptor 1 Ligand TAK-875 Family 2 54
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Integrase Inhibitor L-708,906 Family 1 8
Endothelin-1 receptor Ligand PD156707 Family 41 211
Proto-oncogene tyrosine-protein kinase Src Inhibitor Malonic A... 1 34
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Arachidonate 15-lipoxygenase Inhibitor Isoscopoletin Family 5 98
Platelet-activating factor receptor Ligand L-652731 Family 5 116
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 Ligand... 4 26
Glucocorticoid receptor Ligand 1-methoxy-6-phenyl-6h-benzo[c]c... 2 22
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 2,5-... 2 96
Acetylcholinesterase Inhibitor Territrem B Family 3 21
DNA-dependent protein kinase catalytic subunit Inhibitor 7-pro... 5 49
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
Phospholipase A2 Inhibitor 3,9-dihydroxy-2,10-diprenylpterocap... 9 25
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 127
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Ellagi... 1 11
Acetylcholinesterase Inhibitor AP-2238 Family 2 109
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 160
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 3 9
Kappa-type opioid receptor Ligand Anisocoumarin H Family 3 5
Androgen receptor Ligand 2-methoxy-4-(o-tolyloxy)benzonitrile ... 5 12
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
Amine oxidase [flavin-containing] B Inhibitor (s)(+)-7-fluoro-... 11 11
NAD(P)H dehydrogenase [quinone] 1 Inhibitor Ethyl Bis(4-hydrox... 5 7
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Cytochrome P450 2D6 Inhibitor 4-methylaminomethyl-7-methoxycou... 3 80
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Amine oxidase [flavin-containing] B Inhibitor 4-oxo-4h-chromen... 2 3
Amine oxidase [flavin-containing] B Inhibitor 8-bromo-6-methyl... 5 44
Cytochrome P450 3A4 Inhibitor Diethoxyflourescein Family 3 9
Heat shock cognate 71 kDa protein Inhibitor NSC-119913 Family 2 1
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-c... 5 72
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 0
Tyrosinase Inhibitor 3-(2,4-dihydroxyphenyl)-propionic Acid Et... 3 8
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Androgen receptor Ligand Palodesangren E Family 12 43
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
Tyrosyl-DNA phosphodiesterase 1 and Microtubule-associated pro... 1 1
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 7
Retinoic acid receptor RXR-alpha and Peroxisome proliferator-a... 3 17
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-ben... 5 334
Peroxisome proliferator-activated receptor alpha and Peroxisom... 7 6
Endothelin-1 receptor ligand (2S)-2-(1,3-benzodioxol-5-yl)-4-m... 17 0
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 0
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 7 13
Carbonic anhydrase 2 and Carbonic anhydrase 5A, mitochondrial ... 3 5
Carbonic anhydrase 2 and Carbonic anhydrase 5A, mitochondrial ... 3 2
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 2
Amine oxidase [flavin-containing] A inhibitor AGN-PC-00LZQK fa... 1 24
Acetylcholinesterase and Butyrylcholinesterase inhibitor [3-[[... 1 65
NAD(P)H dehydrogenase [quinone] 1 inhibitor AGN-PC-0AKS1I family 1 0
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 2 2
Solute carrier family 22 member 6 and Histone-lysine N-methylt... 1 1
Neuropeptide Y receptor type 5 and Thioredoxin glutathione red... 13 6
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[2-... 1 0
Multidrug resistance protein 1 inhibitor CHEMBL1 family 2 0
Thioredoxin glutathione reductase and Beta-lactamase inhibitor... 1 0
Cytochrome P450 3A4 inhibitor 4-[(2E)-6-[(E)-3-hydroxy-2,6-dim... 3 2
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 8
Carbonic anhydrase 9 and Carbonic anhydrase 12 inhibitor 5,10-... 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 7
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand LY320135... 1 0
Vitamin K epoxide reductase complex subunit 1 inhibitor AGN-PC... 1 0
Amine oxidase [flavin-containing] B inhibitor (2S)-1-[[7-[(3-f... 2 15
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 1
Benzoxepines Metabolite 4,5-Dihydro-1-benzoxepin-3(2H)-one Family 1 2
Phenylacetic Acid Derivatives Metabolite Guaicyl phenylacetate... 1 3
NP (z)-2-(4-isopropylbenzylidene)-3-oxo-2,3-dihydrobenzofuran-... 16 0
Putative NP ZINC04043753 Family 8 6
diethylcarbamate NP 3-(2,5-dimethoxyphenyl)-4-methyl-2-oxo-2h-... 3 0
2-amino-3-methylpentanoate NP 2-((3-(4-fluorophenoxy)-4-oxo-4h... 13 2
NP 4-(((3-(4-chlorophenyl)-2-methyl-4-oxo-4h-chromen-7-yl)oxy)... 14 0
2-(2-methoxyphenyl)-5-oxooxolane-3-carboxylate NP ZINC00132596... 4 2
NP 2,2,11,12-tetramethyl-3,4,8,9-tetrahydro-2h-cyclopenta[c]fu... 3 1
NP 3-(4-methoxyphenoxy)-4-oxo-4h-chromen-7-yl 4-bromobenzoate ... 13 0
3-pentyl-5-(phenoxymethyl)oxolan-2-one NP ZINC02116245 Family 4 0
NP (z)-2-((2-methyl-2h-chromen-3-yl)methylene)-3-oxo-2,3-dihyd... 74 1
(4-methyl-2-oxochromen-7-yl) (2R)-2-amino-4-methylpentanoate N... 1 0
4-oxochromene-2-carboxylate NP Ethyl 3-(7-(2-(4-bromophenyl)-2... 10 1
NP Ethyl 7-((2-chlorobenzoyl)oxy)-3-(2-methoxyphenyl)-4-oxo-4h... 37 1
orobenzoate NP 3-(2-methoxyphenyl)-2-methyl-4-oxo-4h-chromen-7... 22 0
1-benzofuran-3-one NP ZINC02367988 Family 9 0
benzenesulfonate NP ZINC09051160 Family 47 2
Putative NP ZINC02424323 Family 24 0
bromobenzoate NP ZINC11865066 Family 6 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00300443 CHEMBL146222 Bioactive 3-phenylmethoxy-7,8,9,10-tetrahydrobenzo[c]chromen-6-one
CFAMM00300442 CHEMBL142799 Bioactive 7-phenylmethoxy-2,3-dihydro-1H-cyclopenta[c]chromen-4-one
CFAMM00300437 DNC014140 Investigative Drug 2-[7-(Benzyloxy)-2-oxo-2H-chromen-4-yl]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26830 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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