CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3960
Family Name Prostaglandin G/H synthase 2 Inhibitor 5-methoxy-2-(4-(methylsulfonyl)phenyl)-1h-indole Family
No. of Seeds 3 No. of Other Members 12
Family Centroid CFAMM00300477 Functional Category Investigative Drug
Superfamily Androgen receptor and Oestrogen receptor Binder Superfamily
Class Class 1404

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Serine/threonine-protein kinase PLK1 Inhibitor HMN-214 Family 3 58
Apricoxib family 8 77
Indeglitazar family 3 39
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Plasminogen and Prothrombin Inhibitor 2-(2-hydroxy-phenyl)-1h-... 3 69
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Oestrogen receptor and Estrogen receptor beta Ligand ZK-119010... 2 16
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
Platelet-derived growth factor receptor alpha and Platelet-der... 2 13
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
5-hydroxytryptamine receptor 6 ligand N-[3-[[(2R)-1-methylpyrr... 6 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 5
Cannabinoid receptor 2 ligand AGN-PC-09M5M9 family 1 0
5-hydroxytryptamine receptor 6 ligand SureCN5502542 family 4 2
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 15
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Arachidonate 15-lipoxygenase inhibitor AGN-PC-075CKO family 1 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 2 0
5-hydroxytryptamine receptor 6 ligand CHEMBL1950763 family 1 1
5-hydroxytryptamine receptor 6 ligand SureCN5253197 family 4 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
5-hydroxytryptamine receptor 6 ligand 9-(4-methoxyphenyl)sulfo... 1 0
5-hydroxytryptamine receptor 6 ligand 1-(2-bromo-4-methoxyphen... 2 1
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Neutrophil collagenase and Stromelysin-1 inhibitor (3R)-N-hydr... 2 0
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 6 ligand 1-[9-(2,5-dimethoxypheny... 2 0
5-hydroxytryptamine receptor 6 ligand AGN-PC-075BWR family 1 1
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-difluo... 3 3
Oxytocin receptor and Vasopressin V1a receptor ligand 4-methox... 9 8
5-hydroxytryptamine receptor 6 and Cytochrome P450 3A4 ligand ... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Indoles Metabolite Murrastifoline F Family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00300475 CHEMBL499068 Bioactive SureCN6348857
CFAMM00300474 CHEMBL499069 Bioactive SureCN6341317
CFAMM00300477 DNC014155 Investigative Drug 5-methoxy-2-(4-(methylsulfonyl)phenyl)-1H-indole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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