CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3970
Family Name Prostaglandin G/H synthase 2 Inhibitor 2-(4-(methylsulfonyl)phenyl)-3-phenylquinoline Family
No. of Seeds 7 No. of Other Members 33
Family Centroid CFAMM00300630 Functional Category Investigative Drug
Superfamily Prostaglandin G/H synthase 2 and 5-hydroxytryptamine receptor 6 Binder Superfamily
Class Class 2554

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Prostaglandin G/H synthase 2 Inhibitor Etoricoxib Family 2 99
Thromboxane A2 receptor Ligand Ramatroban Family 13 49
5-hydroxytryptamine receptor 6 Ligand SB-742457 Family 9 66
D(1B) dopamine receptor Ligand LE-300 Family 65 452
E7820 family 9 56
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 22
5-hydroxytryptamine receptor 6 Ligand E-6837 Family 22 44
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 16
5-hydroxytryptamine receptor 6 Ligand 4-(4,6-dinitro-1h-indol-... 4 19
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 14 19
NF-kappa-B Inhibitor 9-chloro-5h-6-thia-4,5-diaza-chrysene 6,6... 3 27
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Arachidonate 15-lipoxygenase Inhibitor PD-146176 Family 1 3
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
C-C chemokine receptor type 5 ligand AC1LAJBP family 2 6
Motilin receptor and Cytochrome P450 2D6 ligand 7-[[6-(4-chlor... 2 1
Protein kinase C theta type and Protein kinase C delta type in... 7 17
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 10 2
5-hydroxytryptamine receptor 6 ligand CHEMBL1950756 family 8 8
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 1 11
Cathepsin L1 inhibitor Bio2_000267 family 9 1
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 1
Cannabinoid receptor 2 ligand AGN-PC-09M5PW family 12 2
Cannabinoid receptor 2 ligand 1,1,1-trifluoro-N-[(1R)-1-[4-[1-... 2 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 5 10
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 4 0
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 2 4
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 4
Prostaglandin G/H synthase 2 inhibitor AGN-PC-03VWKZ family 2 34
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 4-[2-(... 2 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 13 1
5-hydroxytryptamine receptor 6 ligand SureCN3411879 family 10 3
5-hydroxytryptamine receptor 6 and Muscarinic acetylcholine re... 7 3
5-hydroxytryptamine receptor 6 ligand 1-(4-chlorophenyl)sulfon... 8 4
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 12 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
Prostaglandin D2 receptor 2 ligand 2-[5-fluoro-2-methyl-3-[(4-... 3 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 2 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 4 0
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 7 1
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-6-br... 5 1
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 2 0
5-hydroxytryptamine receptor 6 ligand 9-(2-bromophenyl)sulfony... 2 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 5 2
5-hydroxytryptamine receptor 6 ligand 2-methyl-5-methylsulfany... 1 1
Prostaglandin G/H synthase 2 inhibitor 1-(3-fluorophenyl)-2-me... 1 5
Prostaglandin G/H synthase 2 inhibitor 1-(3,4-difluorophenyl)-... 1 3
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 6-(b... 5 5
Capsid scaffolding protein inhibitor AC1O583J family 5 1
Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor 2-(2,6... 3 10
5-hydroxytryptamine receptor 7 ligand 6-[(2R)-2-[2-(4-methylpi... 1 0
5-hydroxytryptamine receptor 6 ligand 3,4-dichloro-N-[3-[[(2R)... 5 0
Prostaglandin G/H synthase 2 inhibitor AGN-PC-03NCPN family 4 0
Prostaglandin G/H synthase 2 inhibitor SureCN6345015 family 6 1
Prostaglandin G/H synthase 2 inhibitor AGN-PC-03NCPD family 6 2
5-hydroxytryptamine receptor 6 ligand 2-[[(1Z)-1-[5-(benzenesu... 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 6 ligand 4-bromo-N-[3-[[(2S)-1-me... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00300637 CHEMBL525250 Bioactive AGN-PC-03NCPL
CFAMM00300657 CHEMBL524543 Bioactive SureCN6342283
CFAMM00300629 CHEMBL197392 Bioactive SureCN4031846
CFAMM00300649 CHEMBL525246 Bioactive AGN-PC-03NCPI
CFAMM00300645 CHEMBL499070 Bioactive AGN-PC-00EVXS
CFAMM00300638 CHEMBL501208 Bioactive AGN-PC-00OX8P
CFAMM00300630 DNC014182 Investigative Drug 2-(4-(methylsulfonyl)phenyl)-3-phenylquinoline

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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