CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3976
Family Name Aldose reductase Inhibitor 3-(3-benzoyl-1h-pyrrol-1-yl)propanoic Acid Family
No. of Seeds 3 No. of Other Members 7
Family Centroid CFAMM00300729 Functional Category Investigative Drug with Human Metabolite
Superfamily Integrase and Aldose reductase Binder Superfamily
Class Class 1565

Cousin Family NamesSeedsMembers
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Thromboxane A2 receptor Ligand Ridogrel Family 7 83
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Cyclooxygenase Inhibitor Ketorolac Family 3 40
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Diacylglycerol O-acyltransferase 2 and Hydroxycarboxylic acid ... 4 45
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Interleukin-1 beta and Interleukin-6 Inhibitor Ibudilast Family 2 11
D(3) dopamine receptor Ligand SB-277011 Family 13 178
D(4) dopamine receptor Ligand SPI-376 Family 7 84
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Integrase Inhibitor L-731,988 Family 1 4
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 3 5
Fatty acid-binding protein, adipocyte and Fatty acid-binding p... 3 11
MO15-related protein kinase Pfmrk Inhibitor (e)-1-(4-nitro-phe... 2 9
Cannabinoid receptor 2 Ligand JWH-204 Family 6 10
Cannabinoid receptor 2 Ligand JWH-249 Family 7 13
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Glutamate receptor 1 Ligand Piriqualone Family 8 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Platelet-activating factor receptor ligand A-85783 family 13 62
Progesterone receptor and Androgen receptor ligand AGN-PC-04V9... 2 2
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
Serine/threonine-protein kinase pim-3 and Serine/threonine-pro... 4 6
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 12
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Prostaglandin D2 receptor 2 ligand 2-[3-[(E)-2-cyano-3-(N-meth... 9 9
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
D(3) dopamine receptor and D(2) dopamine receptor ligand (7S)-... 2 19
72 kDa type IV collagenase and Interstitial collagenase inhibi... 1 1
Histone deacetylase 6 and Histone deacetylase 8 inhibitor N-hy... 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
Prostaglandin E synthase inhibitor 3-(4-dodecanoyl-1,5-dimethy... 2 0
Arachidonate 5-lipoxygenase inhibitor 1-[1-(4-methylphenyl)sul... 1 0
Histone deacetylase 1 and HD2 type histone deacetylase HDA106 ... 1 2
D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 1
Pyrrolizines Metabolite 2,3-Dihydro-5-methyl-1H-pyrrolizine-7-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00300729 DNC014202 Investigative Drug 3-(3-Benzoyl-1H-pyrrol-1-yl)propanoic acid
CFAMM00300732 DNC014204 Investigative Drug 2-(3-benzoyl-1H-pyrrol-1-yl)acetic acid
CFAMM00300731 DNC014203 Investigative Drug 4-(3-Benzoyl-1H-pyrrol-1-yl)butanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45918 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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