CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3984
Family Name Metabotropic glutamate receptor 5 Ligand N-(3-(3-cyanobenzamido)phenyl)-2-methoxybenzamide Family
No. of Seeds 2 No. of Other Members 13
Family Centroid CFAMM00300784 Functional Category Investigative Drug with Natural Product
Superfamily Histone deacetylase 2 and Metabotropic glutamate receptor 5 Binder Superfamily
Class Class 281

Cousin Family NamesSeedsMembers
D(2) dopamine receptor Ligand Nemonapride Family 70 283
Beta-1 adrenergic receptor Ligand Acebutolol Family 2 27
D(4) dopamine receptor Ligand PD-165167 Family 2 96
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Cytochrome P450 1B1 Inhibitor N-(2,4-dimethoxy-phenyl)-3,5-dim... 1 110
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Amyloid beta A4 protein Inhibitor 6-iodo-4'-methylaminoflavone... 3 33
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Gamma-aminobutyric acid receptor Ligand 2-(2-amino-phenyl)-6-m... 4 23
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Nuclear receptor ROR-gamma and Menin ligand CHEMBL1432265 family 1 18
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 7 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Prelamin-A/C and Cruzipain inhibitor CHEMBL1598118 family 1 3
Trace amine-associated receptor 1 ligand EPPTB family 4 9
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 2 0
Sphingosine 1-phosphate receptor 1 ligand 2-methoxy-N-[(4-phen... 2 23
Mitogen-activated protein kinase 14 inhibitor N-[2-fluoro-5-[(... 4 5
D(3) dopamine receptor and D(4) dopamine receptor ligand SureC... 3 19
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 2
Prostaglandin E2 receptor EP1 subtype ligand 3-acetamido-5-[2-... 5 1
Trace amine-associated receptor 1 ligand ZINC07609882 family 2 0
Amine oxidase [flavin-containing] B and Adenosine receptor A2b... 2 2
Major prion protein and Microtubule-associated protein tau inh... 2 10
Ras-related protein Rab-9A and Niemann-Pick C1 protein inhibit... 1 4


External ID

Functional Category

Molecule Name

CFAMM00300779 CHEMBL1080481 Bioactive BAS 00649851
CFAMM00300784 DNC014238 Investigative Drug N-(3-(3-cyanobenzamido)phenyl)-2-methoxybenzamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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