CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3987
Family Name Voltage-dependent calcium channel gamma-1 subunit Ligand NP-118809 Family
No. of Seeds 8 No. of Other Members 9
Family Centroid CFAMM00300841 Functional Category Investigative Drug
Superfamily Kappa-type opioid receptor Ligand Asimadoline Superfamily
Class Class 1062

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Opioid receptor Ligand Methadone Family 3 39
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Sodium channel protein type 5 subunit alpha Ligand Indecainide... 2 41
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family 5 255
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Diet... 29 276
Tumor necrosis factor Inhibitor Thalidomide Family 3 50
DNA Binder Procarbazine Family 8 358
Noradrenergic re-uptake Inhibitor Milnacipran Family 7 51
Peripheral carotid chemoreceptor Ligand Doxapram Family 4 36
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Neuromedin-K receptor Ligand Osanetant Family 38 192
Motilin receptor Ligand GSK962040 Family 30 457
C-C chemokine receptor type 5 Ligand AZD5672 Family 25 70
Substance-P receptor Ligand Orvepitant Family 11 46
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 2 18
Substance-P receptor Ligand Vestipitant Family 14 137
K-604 family 4 71
Pan-DAC Inhibitor AR-42 Family 21 153
Bavisant family 9 65
Neuropeptide Y receptor type 1 Ligand BIBO3304 Family 4 69
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Melanocortin receptor 4 Ligand Ro-27-3225 Family 6 52
Aldose reductase Inhibitor Alrestatin Family 2 11
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Neutrophil elastase Inhibitor FK-706 Family 8 85
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Prothrombin Inhibitor LB30812 Family 12 36
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Prothrombin Inhibitor Ppack Family 5 4
Prothrombin Inhibitor D-leucyl-n-(3-chlorobenzyl)-l-prolinamid... 18 168
Prothrombin Inhibitor D-leucyl-n-(4-carbamimidoylbenzyl)-l-pro... 13 44
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU83876 F... 3 51
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
Poly [ADP-ribose] polymerase 1 Inhibitor 3,4-dihydro-5-methyl-... 3 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 3
Histone deacetylase 1 Inhibitor 8-(3-benzoyl-ureido)-octanoic ... 7 13
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(6... 1 12
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Sodium-dependent dopamine transporter and Sodium-dependent nor... 10 28
Caspase-3 Inhibitor 2-phenethylisoquinoline-1,3,4-trione Family 6 0
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Tic... 11 31
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Acetyl-CoA carboxylase 1 and Acetyl-CoA carboxylase 2 Inhibito... 1 0
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
Dipeptidyl peptidase 4 Inhibitor N4-(4-chlorobenzyl)-2,4-diami... 10 22
Melanocortin receptor 4 and Substance-K receptor Ligand Hoo-ph... 3 19
Cathepsin G and Chymase Inhibitor JNJ-10311795 Family 1 3
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 4 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Serine/threonine-protein kinase Chk1 Inhibitor 6-(3-aminopropy... 2 7
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
Substance-P receptor Ligand [sar9,met(o2)11]-sp Family 34 9
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Fatty-acid amide hydrolase 1 Inhibitor 1-biphenyl-4-ylmethylma... 2 2
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Inhibit... 5 23
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Cathepsin S Inhibitor N-(1-oxobutan-2-yl)-3-(trifluoromethyl)b... 2 10
Aminopeptidase N Inhibitor N1,2-dibenzyl-n3-hydroxymalonamide ... 5 23
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-benza... 3 9
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 80
Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2... 8 13
Aminopeptidase N Inhibitor 2-benzyl-n1-hydroxy-n3-(4-phenylbut... 5 3
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3'... 14 11
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 3 10
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand N-(3-... 1 7
Substance-P receptor ligand AGN-PC-00FJ8P family 6 10
D(4) dopamine receptor ligand AGN-PC-074VC9 family 2 3
C-C chemokine receptor type 5 ligand AC1NUIO8 family 12 11
Cathepsin K inhibitor [(3S)-4,4-dimethyl-1-(naphthalene-2-carb... 4 9
Substance-K receptor ligand 4-(4-methylphenyl)-N-[1-[[(2S)-5-[... 6 0
Substance-K receptor ligand (4S)-4-amino-1-[4-(oxan-4-ylmethyl... 1 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [2... 2 4
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 1 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 2 0
72 kDa type IV collagenase and Matrilysin inhibitor (2S,3R)-N-... 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 7
Muscarinic acetylcholine receptor M2 ligand [4-[(3R)-3-methyl-... 3 4
C-C chemokine receptor type 5 ligand AC1L9USC family 3 2
Kappa-type opioid receptor ligand 6-[2-oxo-2-[(2S)-2-(pyrrolid... 6 4
Kappa-type opioid receptor ligand 1-[(2S)-2-(pyrrolidin-1-ylme... 4 0
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745OU family 6 6
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 3 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 5 11
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 3 13
Growth hormone secretagogue receptor type 1 ligand (E)-5-amino... 2 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 4
Substance-P receptor and Neuromedin-K receptor ligand N-[(3R,4... 2 0
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-2-[... 14 4
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 18
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 1 8
Substance-P receptor ligand AGN-PC-075NUD family 4 1
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 3
Substance-P receptor ligand AGN-PC-075NRR family 2 1
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor lig... 2 0
Acetylcholinesterase inhibitor 5-benzoyl-2-[2-(1-benzylpiperid... 2 3
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 2 0
Prelamin-A/C and Ras-related protein Rab-9A inhibitor CHEMBL15... 1 7
Acetylcholinesterase inhibitor AC1MIM21 family 2 7
5-hydroxytryptamine receptor 1A ligand U93385 family 4 1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor N-[(1S,5aR,9... 2 4
Neuromedin-K receptor ligand SureCN2477089 family 2 4
Prothrombin inhibitor AGN-PC-09QJ23 family 2 5
Chymase and Chymotrypsinogen A inhibitor tert-butyl N-[(2S)-1-... 2 7
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (2S... 16 24
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 7 31
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 0
Mitogen-activated protein kinase 14 and Cytochrome P450 2C9 in... 2 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Gonadotropin-releasing hormone receptor ligand 3-[(2R)-2-amino... 9 21
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... 4 9
Vasopressin V1a receptor ligand N-[(2R)-3-(4-chlorophenyl)-1-[... 6 0
Dipeptidyl peptidase 8 inhibitor (2S)-2-amino-4-[4-[bis(4-fluo... 2 9
Substance-P receptor ligand 3-[bis(4-fluorophenyl)methyl]-1-[[... 2 10
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Melanin-concentrating hormone receptor 1 ligand 1-(3-acetyl-1,... 8 4
Follicle-stimulating hormone receptor ligand AGN-PC-005HER family 5 2
Sigma non-opioid intracellular receptor 1 ligand (10aS)-2-(2-p... 1 2
Lysosomal Pro-X carboxypeptidase inhibitor (2S,3S)-2-[(2-amino... 3 3
Sigma non-opioid intracellular receptor 1 ligand 2-(3-bromophe... 5 1
Lysine-specific histone demethylase 1A and Amine oxidase [flav... 2 1
Delta-type opioid receptor and Potassium voltage-gated channel... 3 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Substance-P receptor ligand (3R,4R)-1-(1-acetylpiperidine-4-ca... 7 3
Substance-P receptor ligand (3S,4S)-N-[[3,5-bis(trifluoromethy... 8 9
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 2 1
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
Somatostatin receptor type 1 and Somatostatin receptor type 4 ... 2 0
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Substance-P receptor and Potassium voltage-gated channel subfa... 4 7
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 2 5
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 4 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 9 0
Substance-P receptor ligand (3R,4R)-1-(1-acetylpiperidine-4-ca... 9 1
Substance-P receptor and Potassium voltage-gated channel subfa... 5 0
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (3R... 6 1
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 8 4
Dipeptidyl peptidase 4 inhibitor 4-cyano-N-[4-[(2S)-2-cyanopyr... 1 1
C-C chemokine receptor type 2 ligand (2S)-N-[[3,5-bis(trifluor... 1 0
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Histamine H3 receptor and Acetylcholinesterase ligand 1-[4-[[4... 1 2
Substance-P receptor ligand AGN-PC-073QYE family 6 11
Melanin-concentrating hormone receptor 1 and Cytochrome P450 2... 3 4
Melanin-concentrating hormone receptor 1 and Potassium voltage... 4 4
C-C chemokine receptor type 2 ligand (1S,3R)-N-[[3-fluoro-5-(t... 22 27
Histamine H3 receptor ligand N-ethyl-3-fluoro-3-[3-fluoro-4-(p... 3 0
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-(cyanomethyl)-... 1 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 4
P2X purinoceptor 7 inhibitor SureCN8516206 family 5 1
Muscarinic acetylcholine receptor M3 and Muscarinic receptor 3... 3 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Cannabinoid receptor 2 ligand 1-adamantyl(1,3-dihydroisoindol-... 1 0
Receptor activity-modifying protein 1 and Calcitonin gene-rela... 2 4
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2-chloro-5-... 3 1
Histamine H3 receptor ligand AGN-PC-01WA6E family 10 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
Nociceptin receptor and Kappa-type opioid receptor ligand Pipe... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 4
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 1
5-hydroxytryptamine receptor 1A ligand [(7S,8R)-7-(dipropylami... 4 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 3 1
Substance-P receptor and Potassium voltage-gated channel subfa... 6 0
Follicle-stimulating hormone receptor ligand N-[[3-[4-[[(2S,5S... 7 0
Sodium-dependent dopamine transporter and Transporter inhibito... 6 0
Substance-P receptor ligand AGN-PC-03I9DJ family 3 0
Substance-P receptor and Potassium voltage-gated channel subfa... 5 1
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 4 0
Prothrombin inhibitor N-[7-amino-1-[2-(4-carbamoylphenyl)ethyl... 8 1
Prolyl endopeptidase inhibitor [(2S)-2-(pyrrolidine-1-carbonyl... 3 0
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
C-C chemokine receptor type 5 ligand AC1LAKMZ family 3 4
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 1 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 5
C-C chemokine receptor type 5 ligand N-[1-[(3R)-4-[benzenesulf... 3 1
Plasmepsin-2 inhibitor SureCN8292428 family 1 2
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 1 0
Melanocortin receptor 4 and Melanocortin receptor 3 ligand (2S... 2 0
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[ethyl-[2-(4... 1 1
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 9
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 1
Oxytocin receptor and Vasopressin V1a receptor ligand N-(cyclo... 4 5
C-C chemokine receptor type 5 ligand N-benzyl-N-[(3R)-1-[(1S,5... 1 3
Lanosterol synthase and Cycloartenol synthase inhibitor (4-bro... 1 2
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
Muscarinic acetylcholine receptor M3 ligand N-[[4-fluoro-3-[3-... 3 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 22
Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family 2 1
5-hydroxytryptamine receptor 1A ligand 8-[4-[[(2R)-8-acetyl-5-... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor N-... 9 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 3
Legumain-like protease inhibitor N-[(2R)-1-[[(2S)-1-[2-(2-amin... 6 7
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Prothrombin inhibitor 1-(2-amino-3,3-diphenylpropanoyl)-N-[(3-... 1 1
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-074TEL... 1 7
B1 bradykinin receptor ligand 4-(4-oxothiochromen-3-yl)-N-[(1R... 1 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 1 1
Beta-secretase 1 inhibitor [(3'S,4R)-7-bromospiro[2,3-dihydro-... 1 0
Substance-P receptor ligand AGN-PC-0760FI family 1 0
C-C chemokine receptor type 2 ligand (2S)-N-[[3,5-bis(trifluor... 1 1
Muscarinic acetylcholine receptor M2 ligand 3-[(1Z)-1-benzylid... 2 0
Lethal(3)malignant brain tumor-like protein 3 and Lethal(3)mal... 1 0
Lanosterol synthase and Squalene--hopene cyclase inhibitor AGN... 2 5
Pdk3 protein and [Pyruvate dehydrogenase (acetyl-transferring)... 3 0
Substance-P receptor ligand AGN-PC-074VYH family 4 0
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 1 1
Coagulation factor X and Coagulation factor VII inhibitor AGN-... 1 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor [4-(2... 1 0
Tryptase alpha/beta-1 inhibitor 4-[[(4-carbamimidoylbenzoyl)am... 1 2
DNA polymerase beta and Muscleblind-like protein 1 inhibitor C... 1 0
Lethal(3)malignant brain tumor-like protein 1 and Kelch-like E... 2 1
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 3 0
Histone deacetylase 6 inhibitor AGN-PC-0C5HOH family 1 1
Histone deacetylase 6 and Histone deacetylase 1 inhibitor AGN-... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00300831 CHEMBL136411 Bioactive AGN-PC-03ITOT
CFAMM00300837 CHEMBL27432 Bioactive AGN-PC-073GFH
CFAMM00300834 CHEMBL335788 Bioactive AGN-PC-075NPP
CFAMM00300832 CHEMBL545096 Bioactive N-[(2S)-1-(4-benzylpiperazin-1-yl)-3-phenylpropan-2-yl]adamantane-1-carboxamide;dihydrochloride
CFAMM00300841 DNC014272 Investigative Drug NP-118809

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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