CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID402
Family Name Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family
No. of Seeds 9 No. of Other Members 69
Family Centroid CFAMM00190559 Functional Category Investigative Drug with Natural Product
Superfamily Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Superfamily
Class Class 1579

Cousin Family NamesSeedsMembers
Acetylcholinesterase Inhibitor Neostigmine Family 4 76
Cyclooxygenase Inhibitor Acetaminophen Family 2 42
Beta-1 adrenergic receptor Ligand Practolol Family 2 82
Acyl-CoA desaturase Inhibitor Isoxyl Family 5 62
D(2) dopamine receptor Ligand Pardoprunox Family 4 81
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
C-C chemokine receptor type 1 Ligand BX-471 Family 10 67
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Alpha-1 adrenergic receptor Ligand DC-015 Family 8 25
5-hydroxytryptamine receptor 6 Ligand Sb 258585 Family 11 121
Inosine-5'-monophosphate dehydrogenase Inhibitor VX-148 Family 2 3
Histamine H3 receptor Ligand UCL1972 Family 3 23
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor Liga... 40 90
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand RWJ-68141 Family 5 4
Alpha-1A adrenergic receptor Ligand Ro-11-04253 Family 1 1
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Carbonic anhydrase 2 Inhibitor 4-methoxyphenylsulfamide Family 2 27
Histone deacetylase 1 Inhibitor 7-(4-(dimethylamino)phenoxy)-n... 2 1
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 11 13
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-... 12 44
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Renin Inhibitor Ro-66-1168 Family 10 30
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Fatty-acid amide hydrolase 1 Inhibitor 2-fluorophenyl 4-(octyl... 15 9
Fatty-acid amide hydrolase 1 Inhibitor Propan-2-one O-4-(hexyl... 12 4
Fatty-acid amide hydrolase 1 Inhibitor Benzaldehyde O-4-ethoxy... 21 4
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Fatty-acid amide hydrolase 1 Inhibitor Phenmedipham Family 2 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 9
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
Beta-1 adrenergic receptor ligand 1-[2-[[(2S)-3-(2-cyanophenox... 10 4
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 4 6
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 18
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-087THW family 1 0
Bifunctional epoxide hydrolase 2 inhibitor SureCN2729784 family 3 9
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
Transient receptor potential cation channel subfamily V member... 3 15
Survival motor neuron protein and DNA-(apurinic or apyrimidini... 1 5
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor SureCN... 2 11
Substance-P receptor ligand (2S,4S)-1-N-(3-chlorophenyl)-2-N-[... 5 2
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 2 4
Survival motor neuron protein and Alpha-galactosidase A inhibi... 1 4
Gastrin/cholecystokinin type B receptor ligand 1-[3-[[2-(3-met... 2 12
Carbonic anhydrase 12 and Probable transmembrane carbonic anhy... 2 0
Gonadotropin-releasing hormone receptor ligand SureCN5756131 f... 5 7
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 5 2
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 1
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4S)-4-(4-methoxya... 1 26
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-[(4... 8 4
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-[(4... 10 0
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-[(2... 2 0
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-[(3... 2 1
Carbonic anhydrase 1 and Carbonic anhydrase 12 inhibitor tert-... 1 0
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 1 0
Bifunctional epoxide hydrolase 2 inhibitor SureCN3178516 family 3 1
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 8
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 3 0
Histamine H3 receptor and Histamine receptor H3 ligand 1-[4-[3... 2 0
Histamine H3 receptor and Histamine receptor H3 ligand 1-(3,5-... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand N-ethyl... 8 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 0
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-fluoro-5-hydro... 2 0
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-ethylbutanoyl)... 11 0
C-X-C chemokine receptor type 3 ligand 1-[1-[(9-acetyl-9-azabi... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
Neuropeptide Y receptor type 5 ligand 3-[4-(4-fluorophenoxy)ph... 4 0
Neuropeptide Y receptor type 5 ligand 1-[1-(4-fluorophenyl)pro... 2 8
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZ6 family 3 6
Neutrophil elastase inhibitor AGN-PC-04S1IE family 1 0
Histamine H3 receptor ligand AGN-PC-077MDJ family 2 1
Melatonin receptor type 1B ligand SureCN8150656 family 2 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 1
Histamine H3 receptor ligand AGN-PC-07ZCFA family 1 0
Peptide deformylase inhibitor (2S)-N-(cyclopropylmethyl)-N-[2-... 1 0
Hormone-sensitive lipase and Acetylcholinesterase inhibitor Su... 2 0
Histone deacetylase 8 and Histone deacetylase 6 inhibitor (3S)... 4 16
C-X-C chemokine receptor type 3 ligand 1-[1-[[(1S,5R)-6,6-dime... 2 3
Menin and Histone-lysine N-methyltransferase 2A inhibitor CHEM... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00190494 CHEMBL1257879 Bioactive AGN-PC-087VCJ
CFAMM00190528 CHEMBL2031937 Bioactive 1,3-bis[4-(trifluoromethoxy)phenyl]urea
CFAMM00190537 CHEMBL1257517 Bioactive AGN-PC-087THX
CFAMM00190514 CHEMBL2047802 Bioactive [4-[(4-methoxyphenyl)carbamoylamino]phenyl] sulfamate
CFAMM00190525 CHEMBL2031931 Bioactive 1-cyclohexyl-3-[4-(trifluoromethoxy)phenyl]urea
CFAMM00190544 CHEMBL1258904 Bioactive AGN-PC-071ISZ
CFAMM00190492 DNC005564 Investigative Drug 1-Cyclohexyl-3-(4-methoxy-phenyl)-urea
CFAMM00190559 DNC000929 Investigative Drug Metazamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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