CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID4021
Family Name Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(3-cyanophenyl)-5-fluorobenzamide Family
No. of Seeds 7 No. of Other Members 5
Family Centroid CFAMM00301247 Functional Category Investigative Drug
Superfamily Metabotropic glutamate receptor 5 and Transient receptor potential cation channel subfamily V member 1 Binder Superfamily
Class Class 2123

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Histone deacetylase 1 Inhibitor Vorinostat Family 26 138
Serum albumin Inhibitor Ebselen Family 3 62
Dual specificity mitogen-activated protein kinase kinase Inhib... 5 13
Motilin receptor Ligand GSK962040 Family 30 457
Poly [ADP-ribose] polymerase 1 Inhibitor BSI-201 Family 3 16
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Dual specificity mitogen-activated protein kinase kinase Inhib... 8 4
Pan-DAC Inhibitor AR-42 Family 21 153
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Peroxisome proliferator-activated receptor gamma and Retinoic ... 4 9
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
Transient receptor potential cation channel subfamily V member... 6 33
Acetylcholinesterase Inhibitor Bw-28c51 Family 3 8
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 1 9
Liver carboxylesterase 1 Inhibitor 4-chloro-1h-indole-2,3-dion... 3 7
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Oxysterols receptor LXR-alpha Ligand 2-(2-phenethylphenyl)isoi... 4 7
Transient receptor potential cation channel subfamily V member... 1 5
Progesterone receptor Ligand 3-(3,3-dimethyl-2-oxoindolin-5-yl... 2 10
Leukotriene A-4 hydrolase Inhibitor N5-[4-benzylphenyl]-l-glut... 2 1
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor Benz... 3 12
Phospholipase D1 Inhibitor Halopemide Family 17 111
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 12
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(2,4... 3 6
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 2 17
Metabotropic glutamate receptor 5 Ligand N-(3-acetamidophenyl)... 4 20
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
MO15-related protein kinase Pfmrk Inhibitor 2-chloro-n-(o-toly... 6 28
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 I... 9 7
D(2) dopamine receptor Ligand PD-168077 Family 6 5
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
Dihydroorotate dehydrogenase Inhibitor N-(4-bromo-2-methylphen... 1 3
Myeloperoxidase Inhibitor 4-aminobenzoic Acid Hydrazide Family 1 3
C-C chemokine receptor type 3 ligand 4-[(3-acetylphenyl)carbam... 3 4
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
C-C chemokine receptor type 3 ligand SureCN6703027 family 2 1
Vasopressin V2 receptor ligand [2-chloro-4-(prop-2-enylamino)p... 3 14
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 2 4
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 3
Follicle-stimulating hormone receptor ligand AGN-PC-005HER family 5 2
Transient receptor potential cation channel subfamily V member... 1 1
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 3
Coagulation factor X inhibitor N-(4-chlorophenyl)-2-[[4-(2-oxo... 2 0
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
Muscarinic acetylcholine receptor M1 and Beta-lactamase ligand... 1 1
Dihydroorotate dehydrogenase (quinone), mitochondrial and Dihy... 1 8
Progesterone receptor ligand AGN-PC-048NI9 family 1 5
Proteinase-activated receptor 1 ligand 2-bromo-N-[3-(butanoyla... 4 0
Poly [ADP-ribose] polymerase 2 and Poly [ADP-ribose] polymeras... 1 0
G protein-activated inward rectifier potassium channel 4 and G... 1 0
Lysophosphatidic acid receptor 3 and Microtubule-associated pr... 1 1
Progesterone receptor ligand AGN-PC-00PB7N family 2 1
3-prop-2-enyl-1H-quinolin-4-one NP 6-amino-2-methylquinolin-4-... 5 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00301246 DNC014417 Investigative Drug 3-cyano-5-fluoro-N-(3-fluorophenyl)benzamide
CFAMM00301245 DNC014416 Investigative Drug N-(3-chlorophenyl)-3-cyano-5-fluorobenzamide
CFAMM00301244 DNC014418 Investigative Drug 3-cyano-5-fluoro-N-phenylbenzamide
CFAMM00301250 DNC014413 Investigative Drug 3-cyano-N-(3-ethynylphenyl)-5-fluorobenzamide
CFAMM00301249 DNC014412 Investigative Drug 3-cyano-N-(3-ethylphenyl)-5-fluorobenzamide
CFAMM00301248 DNC014415 Investigative Drug 3-cyano-5-fluoro-N-m-tolylbenzamide
CFAMM00301247 DNC014414 Investigative Drug 3-cyano-N-(3-cyanophenyl)-5-fluorobenzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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