CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID4022
Family Name Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(pyridin-2-yl)benzamide Family
No. of Seeds 2 No. of Other Members 9
Family Centroid CFAMM00301265 Functional Category Investigative Drug
Superfamily Tubulin beta chain and Metabotropic glutamate receptor 5 Binder Superfamily
Class Class 148

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
Glucose-dependent insulinotropic receptor Ligand APD668 Family 3 8
Transient receptor potential cation channel subfamily V member... 16 295
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Mitogen-activated protein kinase 12 Inhibitor VX-702 Family 3 49
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Histone deacetylase 1 Inhibitor Pyroxamide Family 4 13
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Dipeptidyl peptidase 4 Inhibitor Nvp-dpp728 Family 11 42
XL-888 family 16 85
Class II cytokine receptor Ligand IL-10 Family 7 45
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Tubulin beta chain Inhibitor 7-methyl-2-m-tolyl-1h-[1,8]naphth... 7 15
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor CI-9... 3 13
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Metabotropic glutamate receptor 5 Ligand 3-chloro-n-(6-chlorop... 2 5
Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(6-methylpy... 4 3
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Tubulin beta chain Inhibitor 2-m-tolyl-1h-[1,8]naphthyridin-4-... 5 2
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 1 0
Integrin beta-3 and Integrin alpha-V inhibitor SureCN547914 fa... 8 32
Integrin alpha-V and Integrin beta-5 inhibitor SureCN6563167 f... 2 10
RAC-alpha serine/threonine-protein kinase inhibitor SureCN4728... 11 6
Substance-P receptor ligand (3R,4S)-N-[[3,5-bis(trifluoromethy... 3 7
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 1 0
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZB72 family 10 8
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 2 7
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Reverse transcriptase/RNaseH inhibitor AC1MHDLR family 2 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 1
Cellular tumor antigen p53 inhibitor CHEMBL1551403 family 1 0
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Dipeptidyl peptidase 4 inhibitor SureCN3389584 family 2 2
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 3 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 13 3
B1 bradykinin receptor ligand 6-(8-fluoro-4-methyl-1-oxophthal... 3 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 3 2
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 9 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
Cell division cycle 7-related protein kinase and Protein DBF4 ... 1 5
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
5-hydroxytryptamine receptor 3A ligand 3-methyl-N-[7-[[3-methy... 2 0
Dipeptidyl peptidase 4 inhibitor 2-[[2-[(3R)-3-aminopiperidin-... 1 0
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]... 3 1
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 1 0
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 3 1
B1 bradykinin receptor ligand methyl 2-fluoro-6-[3-fluoro-4-[[... 22 11
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 6 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Poly [ADP-ribose] polymerase 1 inhibitor 8-[[4-fluoro-3-(4-pyr... 5 2
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-isoquinolin-1-y... 3 2
Substance-P receptor ligand Netupitant family 5 2
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Smoothened homolog inhibitor 3-pyridin-3-yl-N-[1-[[6-[4-[(3-py... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
ALK tyrosine kinase receptor ligand N-[6-[[4-(2-hydroxypropan-... 2 0
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 4 0
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 6 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-(6-pyrrolid... 3 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor 6-... 1 0
G-protein coupled bile acid receptor 1 ligand 2-(ethylamino)-6... 5 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Beta-secretase 1 and Beta-secretase 2 inhibitor SureCN14726714... 4 1
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 7 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Prothrombin inhibitor N-[(6-amino-2-methylpyridin-3-yl)methyl]... 2 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 1
Integrin beta-3 and Integrin alpha-V inhibitor 2-[(2S)-4-methy... 2 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 2
Cathepsin S and Cathepsin K inhibitor AGN-PC-00CD7W family 5 5
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
Macrophage colony-stimulating factor 1 receptor ligand N-[3-[(... 5 0
Adenosine receptor A1 and Adenosine receptor A3 ligand CHEMBL4... 2 0
Transient receptor potential cation channel subfamily V member... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 0
Beta-secretase 1 and Beta-secretase 2 inhibitor SureCN4964150 ... 3 0
Transient receptor potential cation channel subfamily V member... 3 2
Poly [ADP-ribose] polymerase 1 inhibitor Piperazine analogue, ... 4 0
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 2 2
Cannabinoid receptor 2 ligand AGN-PC-07CRHA family 4 8
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 1
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethy... 9 1
Histamine H3 receptor ligand 6-[4-[2-[(2R)-2-methylpyrrolidin-... 1 0
Cannabinoid receptor 2 ligand AGN-PC-00SRU5 family 2 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Stromelysin-1 and Interstitial collagenase inhibitor 1-[(2S)-1... 1 3
P2X purinoceptor 7 inhibitor N'-pyridin-2-yladamantane-1-carbo... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00301264 CHEMBL1270423 Bioactive AGN-PC-087ZLG
CFAMM00301265 DNC014420 Investigative Drug 3-cyano-5-fluoro-N-(pyridin-2-yl)benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24631 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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