CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID4036
Family Name Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-(2-methylpyridine)methylphenidate Family
No. of Seeds 4 No. of Other Members 12
Family Centroid CFAMM00301557 Functional Category Investigative Drug
Superfamily Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-(2-methylpyridine)methylphenidate Superfamily
Class Class 1127

Cousin Family NamesSeedsMembers
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Muscarinic acetylcholine receptor M4 Ligand Tropicamide Family 3 73
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Thromboxane A2 receptor Ligand Ridogrel Family 7 83
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Histamine H1 receptor Ligand (s)-(+)-dimethindene Maleate Family 6 12
Prothrombin Inhibitor Ximelegatran Family 8 157
Proteinase-activated receptor 1 Ligand SCH-530348 Family 20 215
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Substance-P receptor Ligand TAK-637 Family 18 63
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
FK506-binding protein 1A Inhibitor Gpi-1046 Family 4 10
Integrin beta-3 Inhibitor Elarofiban Family 28 45
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Alpha-1A adrenergic receptor Ligand L-771688 Family 8 14
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase inhibit... 2 24
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase inhibit... 4 8
C-C chemokine receptor type 5 ligand AC1LA259 family 1 1
Sodium-dependent serotonin transporter and Sodium-dependent do... 6 4
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 4 0
Sterol O-acyltransferase 1 inhibitor dodecyl 3-[2,6-di(propan-... 1 2
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 0
Metabotropic glutamate receptor 5 ligand AGN-PC-075X3Y family 2 6
Egl nine homolog 1 inhibitor 2-[5-methyl-6-[[1-oxo-2-(4-phenyl... 4 3
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 10 2
G-protein coupled bile acid receptor 1 ligand 1-[4-[(1R,3E)-1-... 1 1
Thromboxane-A synthase inhibitor 7-[(2S,3R)-3-pyridin-3-yl-2-b... 1 1
Platelet-activating factor receptor ligand SureCN9853140 family 3 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00301552 CHEMBL1921922 Bioactive [(3R)-1-[3-(6-methylpyridin-3-yl)propyl]-1-azoniabicyclo[2.2.2]octan-3-yl] (2S)-2-phenyl-2-piperidin-1-ylpropanoate
CFAMM00301558 CHEMBL1921919 Bioactive [(3R)-1-[3-(2-methylpyridin-4-yl)propyl]-1-azoniabicyclo[2.2.2]octan-3-yl] (2S)-2-phenyl-2-piperidin-1-ylpropanoate
CFAMM00301557 DNC014463 Investigative Drug (+/-)-threo-N-(2-Methylpyridine)methylphenidate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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