CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID4037
Family Name Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-(2-methylfuran)methylphenidate Family
No. of Seeds 4 No. of Other Members 62
Family Centroid CFAMM00301575 Functional Category Investigative Drug with Natural Product
Superfamily Fatty-acid amide hydrolase 1 and Sodium-dependent dopamine transporter Binder Superfamily
Class Class 2912

Cousin Family NamesSeedsMembers
Dopamine reuptake and Noradrenergic re-uptake Inhibitor Cocain... 13 136
Histamine H3 receptor Ligand ABT-239 Family 8 20
Alpha-2C adrenergic receptor Ligand MK-912 Family 1 3
Histamine H3 receptor Ligand A-317920 Family 9 240
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 4-(2... 4 31
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 66
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 14
Histamine H3 receptor Ligand A-349821 Family 49 228
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 4 18
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 5 11
Fatty-acid amide hydrolase 1 Inhibitor Furan-2-ylmethylcarbami... 1 105
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 8 36
Sodium-dependent dopamine transporter and Sigma non-opioid int... 7 5
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 2 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 4 1
Prothrombin inhibitor 3-[3-(diaminomethylideneamino)oxypropoxy... 6 3
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 20 9
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 2 2
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 0
Sodium-dependent dopamine transporter and Transporter inhibito... 5 1
Sodium/iodide cotransporter inhibitor (3-methoxyphenyl)methyl ... 4 12
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 10
Lethal(3)malignant brain tumor-like protein 1 and Lysine-speci... 1 6
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1424193 family 1 0
Histamine H3 receptor ligand SureCN2786002 family 8 3
Prostaglandin E2 receptor EP4 subtype ligand SureCN5653729 family 3 2
Histamine H3 receptor ligand SureCN2784769 family 12 2
Histamine H3 receptor ligand SureCN2785131 family 7 1
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 7 18
Mu-type opioid receptor ligand AGN-PC-075GAC family 16 8
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase and Sigma no... 2 4
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 0
Histamine H3 receptor ligand 2-(3,3-difluoropyrrolidin-1-yl)-1... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 0
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 3 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 1
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 2 4
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 1
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 0
5-hydroxytryptamine receptor 1A ligand 8-[4-[[(2R)-5-fluoro-8-... 2 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 5 4
Protein kinase C theta type and Protein kinase C epsilon type ... 1 0
Glutamate carboxypeptidase 2 inhibitor (2S)-2-[[(1S)-1-carboxy... 1 0
Gonadotropin-releasing hormone receptor ligand N-[[4-[(diamino... 6 4
Putative NP ZINC02134473 Family 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00301627 CHEMBL199704 Bioactive methyl 3-[4-(furan-2-yl)phenyl]-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00301575 DNC014466 Investigative Drug (+/-)-threo-N-(2-Methylfuran)methylphenidate
CFAMM00301576 DNC014469 Investigative Drug (+/-)-threo-N-(3-Methylfuran)methylphenidate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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