CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID4040
Family Name Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3',4'-dichloromethylphenidate Amide Family
No. of Seeds 14 No. of Other Members 11
Family Centroid CFAMM00301692 Functional Category Investigative Drug
Superfamily Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3',4'-dichloromethylphenidate Amide Superfamily
Class Class 2975

Cousin Family NamesSeedsMembers
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
Noradrenergic re-uptake and Serotonin re-uptake inhibitor phen... 18 41
Alpha-2 adrenergic receptor ligand opiate Meperidine Family 13 76
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family 5 255
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Diet... 29 276
Acetylcholinesterase Inhibitor Ambenonium Family 4 71
Mu-type opioid receptor Ligand Anileridine Family 3 18
Mu-type opioid receptor Ligand Diphenoxylate Family 5 6
Noradrenergic re-uptake Inhibitor Milnacipran Family 7 51
Sodium-dependent dopamine transporter Inhibitor Ioflupane I-12... 130 181
Neuromedin-K receptor Ligand Osanetant Family 38 192
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
Dopamine reuptake and Noradrenergic re-uptake Inhibitor Dov 21... 16 89
Dopamine reuptake and Noradrenergic re-uptake Inhibitor GSK372... 7 61
Tumor necrosis factor Inhibitor Talactoferrin Alfa Family 26 131
Bavisant family 9 65
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Scytalone dehydratase Inhibitor Carpropamid Family 5 2
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Prothrombin Inhibitor D-leucyl-n-(3-chlorobenzyl)-l-prolinamid... 18 168
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor Bexlosteride... 5 23
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 10 52
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 6 7
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Dipeptidyl peptidase 4 Inhibitor 2-(2-chlorophenyl)-2-morpholi... 2 34
Dipeptidyl peptidase 4 Inhibitor N4-(4-chlorobenzyl)-2,4-diami... 10 22
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 8 30
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 5 6
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand N-(3-... 1 7
Sigma non-opioid intracellular receptor 1 ligand NCI60_038428 ... 5 9
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 1 1
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 4 13
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 7 9
Substance-K receptor and Substance-P receptor ligand N-[4-[[4-... 1 4
Melanocortin receptor 4 and Melanocortin receptor 5 ligand Sur... 25 14
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 1 1
Sodium-dependent dopamine transporter and Transporter inhibito... 4 3
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 18
Sodium-dependent serotonin transporter and Transporter inhibit... 6 9
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2,5-dichlor... 3 4
Substance-P receptor ligand AGN-PC-075NUD family 4 1
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 18 4
Pyruvate kinase PKM and Huntingtin inhibitor CHEMBL1455935 family 1 3
Substance-P receptor ligand 4-[1-[2-[1-(cyclopropylmethyl)-3-(... 10 6
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 2
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 9 0
Substance-K receptor ligand (5S)-1-(2-cyclopropylethyl)-5-(3,4... 10 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 5 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 3 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 2 0
Prelamin-A/C and Ras-related protein Rab-9A inhibitor CHEMBL15... 1 7
Sigma non-opioid intracellular receptor 1 ligand 1-[2-(3,4-dic... 8 4
Substance-K receptor and Substance-P receptor ligand N-[(2Z,3R... 26 4
Neuromedin-K receptor ligand (1S,2R)-1-(3,4-dichlorophenyl)-N-... 8 0
Prothrombin inhibitor AGN-PC-09QJ23 family 2 5
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
Prostaglandin D2 receptor 2 ligand SureCN4942606 family 2 8
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 6 0
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 7 31
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 7 16
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... 4 9
Vasopressin V1a receptor ligand (2R)-3-(4-chlorophenyl)-2-[[2-... 6 2
Vasopressin V1a receptor ligand N-[(2R)-3-(4-chlorophenyl)-1-[... 6 0
Dipeptidyl peptidase 8 inhibitor (2S)-2-amino-4-[4-[bis(4-fluo... 2 9
Kappa-type opioid receptor ligand 3,4-dichloro-N-[2-[[(1S)-2-[... 1 0
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 6 9
Substance-K receptor ligand SureCN3083325 family 4 0
Transporter and Sodium-dependent dopamine transporter inhibito... 6 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075C6K ... 3 22
Lysosomal Pro-X carboxypeptidase inhibitor (2S,3S)-2-[(2-amino... 3 3
Sigma non-opioid intracellular receptor 1 ligand 2-(3-bromophe... 5 1
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (3R... 7 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (3R... 6 1
Sodium-dependent serotonin transporter and Sodium-dependent do... 6 3
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 8 4
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 3
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-(cyanomethyl)-... 1 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 4
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 1
Transporter and Sodium-dependent serotonin transporter inhibit... 8 6
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Receptor activity-modifying protein 1 and Calcitonin gene-rela... 2 4
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2-chloro-5-... 3 1
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 4
Histamine H3 receptor ligand AGN-PC-01WA6E family 10 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 6 0
Sodium-dependent dopamine transporter inhibitor ethyl (3S,4S)-... 6 11
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 2 6
Sodium-dependent dopamine transporter and Transporter inhibito... 6 0
Mu-type opioid receptor ligand CHEMBL303404 family 1 1
Sigma non-opioid intracellular receptor 1 ligand NCI60_039912 ... 2 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor methyl ... 6 2
Transporter and Sodium-dependent serotonin transporter inhibit... 4 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[ethyl-[2-(4... 1 1
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 9
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 1
Free fatty acid receptor 1 ligand (3R,4R)-3-(3,4-dichloropheny... 1 0
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[(3,4-dichlo... 1 0
Sigma non-opioid intracellular receptor 1 and Muscarinic acety... 2 3
Neuromedin-K receptor and Substance-K receptor ligand AGN-PC-0... 2 0
Sodium-dependent serotonin transporter and Transporter inhibit... 1 0
Transporter and Sodium-dependent dopamine transporter inhibito... 1 5
Transporter and Sodium-dependent dopamine transporter inhibito... 2 1
Sodium-dependent dopamine transporter and Transporter inhibito... 1 1
Aldose reductase inhibitor SureCN8804611 family 2 0
Substance-P receptor ligand 1-benzyl-3-[bis(4-chlorophenyl)met... 1 3
Histamine H3 receptor ligand (2S)-N-[(3,4-dichlorophenyl)methy... 2 2
Sigma non-opioid intracellular receptor 1 and Muscarinic acety... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 1
C-C chemokine receptor type 3 ligand AGN-PC-075CFD family 2 0
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 1 0
[(1R,9aR)-1,2,3,4,5,6,7,8,9,9a-decahydroquinolizin-5-ium-1-yl]... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00301697 CHEMBL77286 Bioactive T6145327
CFAMM00301703 CHEMBL433849 Bioactive AGN-PC-002MQ1
CFAMM00301689 CHEMBL139156 Bioactive N-[1-[(3,4-dichlorophenyl)methyl]piperidin-4-yl]-2-phenylacetamide
CFAMM00301702 CHEMBL2111856 Bioactive 2-(3,4-dichlorophenyl)-1-[(2S)-2-[(dimethylamino)methyl]piperidin-1-yl]ethanone
CFAMM00301695 CHEMBL552844 Bioactive methyl (2S)-2-(3,4-dichlorophenyl)-2-[(2S)-piperidin-2-yl]acetate;hydrochloride
CFAMM00301701 CHEMBL1173754 Bioactive 1-[(1S,6R)-1-(3,4-dichlorophenyl)-4-azabicyclo[4.1.0]heptan-6-yl]ethanone
CFAMM00301694 CHEMBL1179011 Bioactive methyl (2R)-2-(3,4-dichlorophenyl)-2-[(2R)-piperidin-2-yl]acetate
CFAMM00301685 CHEMBL460845 Bioactive N-[(1S)-3-[4-[[2-(3,4-dichlorophenyl)acetyl]-ethylamino]piperidin-1-yl]-1-phenylbutyl]cyclobutanecarboxamide
CFAMM00301692 DNC014484 Investigative Drug (+/-)-threo-3',4'-Dichloromethylphenidate amide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27254 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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