CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID4041
Family Name Acetylcholinesterase Inhibitor Lysicamine Family
No. of Seeds 2 No. of Other Members 8
Family Centroid CFAMM00301722 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Acetylcholinesterase Inhibitor Lysicamine Superfamily
Class Class 2976

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Proteinase-activated receptor 1 Ligand SCH-530348 Family 20 215
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Vascular endothelial growth factor receptor 2 Ligand E 7080 Fa... 7 17
Smoothened homolog Inhibitor LDE225 Family 3 76
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... 3 7
Metabotropic glutamate receptor 1 Ligand JNJ-16259685 Family 3 20
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [4... 1 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Endothelin-1 receptor and Endothelin B receptor ligand 3-(1,3-... 1 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
Ferritin light chain and Ras-related protein Rab-9A inhibitor ... 1 11
Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... 4 23
B2 bradykinin receptor ligand SureCN6640854 family 7 4
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 7
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Metabotropic glutamate receptor 2 and Metabotropic glutamate r... 3 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Prostaglandin D2 receptor 2 ligand SureCN137822 family 3 0
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Serine/threonine-protein kinase B-raf inhibitor furan-based co... 6 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... 4 4
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Integrase inhibitor (Z)-4-[1-[(4-fluorophenyl)methyl]-5-methox... 1 0
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Proteinase-activated receptor 1 ligand (3R,3aR,4S,5R,6S,7aS)-5... 2 3
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 4
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 12 3
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Prostaglandin E synthase inhibitor 3-[4-(3-cyanopropoxy)-3-met... 2 4
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 11 7
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Serine/threonine-protein kinase Chk1 inhibitor SureCN4854955 f... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 4 1
Vascular endothelial growth factor receptor 2 ligand 6-(6,7-di... 4 0
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 3
Prothrombin and Trypsin-1 inhibitor AGN-PC-074I4I family 3 1
Cannabinoid receptor 1 ligand (4-hydroxynaphthalen-1-yl)-[1-(2... 2 0
Pol polyprotein inhibitor Tertiary Amide deriv. 58 family 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor AGN-... 1 3
Proteinase-activated receptor 1 ligand ethyl N-[(1R,3aR,4aR,6R... 1 4
Ras guanyl-releasing protein 3 and Protein kinase C alpha type... 2 6
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 1 12
Mitogen-activated protein kinase 14 inhibitor (4E)-4-[3-amino-... 1 4
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 2 3
DNA-dependent protein kinase catalytic subunit inhibitor 2-mor... 1 4
Mitogen-activated protein kinase 14 inhibitor Aminopyridine N-... 3 1
M-phase inducer phosphatase 2 and Dual specificity protein pho... 1 0
DNA polymerase beta and Microtubule-associated protein tau inh... 1 1
Menin and Histone-lysine N-methyltransferase 2A inhibitor CHEM... 1 0
Aldose reductase inhibitor [1-(3,5-difluoro-4-hydroxyphenyl)py... 3 2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00301718 CHEMBL1651055 Bioactive CHEMBL1651055
CFAMM00301722 DNC014496 Investigative Drug LYSICAMINE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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