CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID4056
Family Name Cholecystokinin receptor type A Ligand CR-1795 Family
No. of Seeds 19 No. of Other Members 41
Family Centroid CFAMM00301916 Functional Category Investigative Drug with Natural Product
Superfamily Kappa-type opioid receptor and Delta-type opioid receptor Binder Superfamily 6
Class Class 884

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor Ligand Felypressin Family 12 820
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Penicillin binding protein inhibitor β-lactam aminopenicillin ... 12 359
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme inhibitor Phosphonate-containing... 7 41
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Diet... 29 276
Tumor necrosis factor Inhibitor Thalidomide Family 3 50
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
DNA Binder Procarbazine Family 8 358
Prothrombin Inhibitor Ximelagatran Family 5 48
Bacterial outer membrane Inhibitor Polymyxin B Family 17 181
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Angiotensin-converting enzyme and Neprilysin Inhibitor M100,24... 18 60
Dopamine reuptake Inhibitor Amineptine Family 2 5
Iofolastat I-124 family 6 33
Bavisant family 9 65
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Integrin alpha-V and Integrin beta-3 Inhibitor C[rgd-(s)-alpha... 19 95
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Prothrombin Inhibitor Efegatran Family 9 47
Neutrophil elastase Inhibitor FK-706 Family 8 85
Neprilysin Inhibitor Thiorphan Family 41 68
Prothrombin Inhibitor LB30812 Family 12 36
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Neuromedin-K receptor Ligand Senktide Family 15 22
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU85053 F... 6 8
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Thymidylate synthase Inhibitor Sp-876 Family 7 117
Penicillin-binding protein 1B Inhibitor N-benzoyl-d-alanine Fa... 1 40
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
Integrin alpha-V and Integrin beta-3 Inhibitor Cyclo-[-arg-gly... 5 38
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Disintegrin and metalloproteinase domain-containing protein 17... 8 7
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
Integrin beta-3 Inhibitor L-709780 Family 9 10
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 3
Integrin beta-3 Inhibitor DMP-728 Family 3 0
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Histone deacetylase 1 Inhibitor 8-(3-benzoyl-ureido)-octanoic ... 7 13
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(6... 1 12
Beta-secretase 1 Inhibitor Glu-leu-asp-leu-(choh-ch2)-ala-ala-... 15 11
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Tic... 11 31
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Trifunctional purine biosynthetic protein adenosine-3 Inhibito... 2 11
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Delta-type opioid receptor Ligand H-cxp-ala-gly-phe-leu-oh Family 1 8
Serine/threonine-protein kinase Chk1 Inhibitor 6-(3-aminopropy... 2 7
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Integrin alpha-V Inhibitor C[rgdf-(3s)-carboxymorpholine] Family 10 2
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-137546 Family 1 3
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-154957 Family 2 3
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-348926 Family 2 15
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Inhibit... 5 23
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Cathepsin S Inhibitor N-(1-oxobutan-2-yl)-3-(trifluoromethyl)b... 2 10
Endothelin-converting enzyme 1 Inhibitor PO3 2-leu-nal-o-3k Fa... 3 26
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 80
Genome polyprotein Inhibitor Acasp-glu-dif-glu-cha-cys Family 13 17
Genome polyprotein Inhibitor Acasp-glu-met-glu-cha-cys Family 3 6
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 3 10
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 3 18
Substance-P receptor ligand AGN-PC-00FJ8P family 6 10
Angiotensin-converting enzyme inhibitor (S)-1-((S)-5-benzamido... 5 2
Beta-secretase 1 and Cathepsin D inhibitor (1R,3S)-N-[(2S,3S)-... 2 25
Chymotrypsin-like elastase family member 2A and Chymotrypsinog... 2 18
Substance-K receptor ligand 4-(4-methylphenyl)-N-[1-[[(2S)-5-[... 6 0
72 kDa type IV collagenase and Matrilysin inhibitor (2S,3R)-N-... 1 0
C-C chemokine receptor type 5 ligand AC1L9USC family 3 2
Neprilysin and Aminopeptidase N inhibitor (2S)-2-[[(2S)-2-[[[a... 13 1
Carboxypeptidase B and Carboxypeptidase B2 inhibitor (2S)-7-am... 3 9
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 inhibit... 1 2
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 3 13
Caspase-1 inhibitor (3S)-3-[[(2S)-4-(2-naphthalen-1-ylethylami... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 5 3
Growth hormone secretagogue receptor type 1 ligand (E)-5-amino... 2 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 6 6
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 0
Pol polyprotein inhibitor 152928-55-7 family 23 2
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 3
Renin and Cathepsin D inhibitor (3S)-4-[[6-acetamido-2-[[3-nap... 6 26
Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7285564... 1 2
Neprilysin inhibitor SureCN489232 family 3 9
Prostaglandin D2 receptor ligand AGN-PC-09QGM4 family 1 0
Growth factor receptor-bound protein 2 ligand 2-[(9S,10S,11E,1... 5 14
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2R)-2-... 2 1
Stromelysin-1 inhibitor 6-(4'-FLUORO-BIPHENYL-4-YL)-4-(3-METHY... 3 0
Tryptase alpha/beta-1 inhibitor methyl 3-[3-(aminomethyl)pheny... 1 3
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7961093... 1 0
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Caspase-1 inhibitor AGN-PC-075AEI family 3 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Growth factor receptor-bound protein 2 ligand [4-[[(2S,5S,9S,1... 2 1
Mitogen-activated protein kinase 14 and Cytochrome P450 2C9 in... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Endothelin-converting enzyme 1 and Cathepsin D inhibitor N-[(2... 6 2
Pol polyprotein inhibitor 3-[(4R,5R,6R)-4-benzyl-3-(3-carbamoy... 3 1
Beta-secretase 1 inhibitor (2S)-2-[(3R)-3-acetamido-3-(2-methy... 3 0
Prostaglandin E2 receptor EP4 subtype and Prostaglandin E2 rec... 13 22
Substance-P receptor ligand (3S,4S)-N-[[3,5-bis(trifluoromethy... 8 9
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Caspase-1 and Caspase-8 inhibitor (4S,7S,11aS)-2-(benzenesulfo... 2 8
Caspase-1 and Caspase-8 inhibitor (4S,7S,11aS)-7-benzamido-N-[... 7 18
Caspase-1 and Caspase-8 inhibitor (4S,7S,11aS)-7-benzamido-N-[... 3 0
Caspase-1 and Caspase-8 inhibitor (4S,7S,9Z,11aS)-N-[(3S)-2-hy... 2 3
C-C chemokine receptor type 2 ligand N-[2-[[(2S,3S)-1-[(2,4-di... 13 8
C-C chemokine receptor type 2 ligand N-[3-amino-5-(trifluorome... 4 1
Somatostatin receptor type 1 and Somatostatin receptor type 4 ... 2 0
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Peptide deformylase inhibitor (2S)-N-benzoyl-1-[(2R)-2-(cyclop... 2 2
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-1-... 3 3
Dipeptidyl peptidase 4 inhibitor 4-cyano-N-[4-[(2S)-2-cyanopyr... 1 1
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Muscarinic acetylcholine receptor M3 and Muscarinic receptor 3... 3 0
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
Proteasome subunit beta type-5 inhibitor (2R,3S)-3-[(2S)-butan... 1 9
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 1 162
Glutamate carboxypeptidase 2 inhibitor (2S)-2-[[(1R)-1-carboxy... 8 0
Caspase-1 and Caspase-8 inhibitor N-[(6S)-3-(benzamidomethyl)-... 4 4
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 5 3
Beta-secretase 1 inhibitor 1-N-[(1R,2S)-1-[(2R,4S)-4-butoxypip... 5 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2S,4R)... 5 8
Pol polyprotein inhibitor tert-butyl N-[(2S,3S,5S)-3-hydroxy-5... 4 12
Pol polyprotein inhibitor AC1LAMTC family 6 0
Type-2 angiotensin II receptor ligand SureCN3515167 family 2 0
Neprilysin inhibitor SureCN7437961 family 2 6
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-2-(benze... 2 2
Prothrombin inhibitor N-[7-amino-1-[2-(4-carbamoylphenyl)ethyl... 8 1
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN6949669... 12 3
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-2-(2-eth... 1 0
Pol polyprotein inhibitor Enantiomer of AG1284 family 7 1
Angiotensin-converting enzyme and Histone-lysine N-methyltrans... 1 19
Chymase and Chymotrypsinogen B inhibitor AGN-PC-075LTI family 2 3
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 1 2
Angiotensin-converting enzyme and Angiotensin-converting enzym... 1 0
Prolyl endopeptidase and Seprase inhibitor [(2R)-1-[2-[benzoyl... 2 0
Histone deacetylase 1 and Histone deacetylase 8 inhibitor meth... 1 3
Neutrophil elastase inhibitor 4-[(E)-3-[[(2S)-3-methyl-1-oxo-1... 2 6
Angiotensin-converting enzyme inhibitor SureCN7263641 family 2 11
Melanocortin receptor 4 and Melanocortin receptor 3 ligand (2S... 2 0
Calpain-1 catalytic subunit inhibitor Peptidyl alpha-Ketoacid,... 1 0
Muscarinic acetylcholine receptor M3 ligand N-[[4-fluoro-3-[3-... 3 0
Cathepsin S and Cathepsin L1 inhibitor (Z,3S)-1-diazonio-3-[[2... 1 0
Growth hormone-releasing hormone receptor ligand (1S)-1'-[(2R)... 7 4
Neutrophil elastase inhibitor 3-[[(2S)-3-methyl-1-oxo-1-[2-[(1... 1 0
Legumain-like protease inhibitor N-[(2R)-1-[[(2S)-1-[2-(2-amin... 6 7
Interstitial collagenase and 72 kDa type IV collagenase inhibi... 1 1
Ribonucleoside-diphosphate reductase large subunit and Ribonuc... 1 0
Gamma-secretase subunit PEN-2 inhibitor SureCN5966881 family 1 9
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 0
Breast cancer type 1 susceptibility protein inhibitor (2S)-2-[... 1 0
Angiotensin-converting enzyme inhibitor (2S)-2-[[[(2S)-2-carbo... 1 0
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 1 0
NS3 inhibitor 6-[[(2S)-1-[[(2S)-1-[(2S)-2-[[1-(cyclopropylamin... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (3S,6R,11R,14S)... 2 0
Caspase-1 inhibitor (3S)-4-oxo-3-[[(2S)-4-oxo-4-[(3-oxo-3-phen... 1 1
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 0
Legumain inhibitor ethyl (E)-4-[[[(2S)-1-[4-(acetamidomethyl)b... 1 0
PhzR inhibitor tert-butyl N-[[4-[[(3S)-2-oxooxolan-3-yl]carbam... 1 0
Caspase-1 inhibitor (3S)-3-[2-[6-benzyl-2-oxo-3-(3-phenylpropa... 4 1
Receptor-type tyrosine-protein phosphatase C ligand SureCN6261... 1 1
4-methyl-2-[[(E)-3-phenylprop-2-enyl]azaniumyl]pentanoate NP 2... 4 6
NP Methyl 5-((2s,3s,4r)-4-benzamido-3-chlorotetrahydrothiophen... 4 0
(2S)-2-[(3aR,6aS)-2,5-dioxo-3,3a,6,6a-tetrahydro-1H-imidazo[4,... 1 0
Putative NP ZINC08764865 Family 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00301925 CHEMBL176584 Bioactive (3S)-5-[hexyl(methyl)amino]-3-[2-[3-(naphthalene-2-carbonylamino)-2-oxopyridin-1-yl]butanoylamino]-4-oxopentanoic acid
CFAMM00301896 CHEMBL589552 Bioactive (3S)-3-[[(2S)-2-[[(2S)-3-methyl-2-(naphthalene-2-carbonylamino)butanoyl]amino]propanoyl]amino]-4-oxobutanoic acid
CFAMM00301909 CHEMBL115090 Bioactive SureCN8237540
CFAMM00301872 CHEMBL111965 Bioactive 3-[[(2S)-2-[3-(naphthalene-2-carbonylamino)-2-oxopyridin-1-yl]butanoyl]amino]-4-oxo-5-(2-phenylethylamino)pentanoic acid
CFAMM00301908 CHEMBL368078 Bioactive (3S)-5-(dihexylamino)-3-[2-[3-(naphthalene-2-carbonylamino)-2-oxopyridin-1-yl]butanoylamino]-4-oxopentanoic acid
CFAMM00301901 CHEMBL367714 Bioactive SureCN8245871
CFAMM00301870 CHEMBL176512 Bioactive (3S)-5-[butyl(ethyl)amino]-3-[2-[3-(naphthalene-2-carbonylamino)-2-oxopyridin-1-yl]butanoylamino]-4-oxopentanoic acid
CFAMM00301928 CHEMBL369634 Bioactive (3S)-5-(benzylamino)-3-[2-[3-(naphthalene-2-carbonylamino)-2-oxopyridin-1-yl]butanoylamino]-4-oxopentanoic acid
CFAMM00301906 CHEMBL366534 Bioactive (3S)-5-(hexylamino)-3-[2-[3-(naphthalene-2-carbonylamino)-2-oxopyridin-1-yl]butanoylamino]-4-oxopentanoic acid
CFAMM00301899 CHEMBL583488 Bioactive (2S)-2-[[(2S)-2-[[(3S)-2-[(2S)-2-amino-3-(4-carbamoyl-2,6-dimethylphenyl)propanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoic acid
CFAMM00301927 CHEMBL131552 Bioactive (2S)-1-[(2R)-2-[[(2S)-2-benzamido-3-phenylpropanoyl]amino]propanoyl]pyrrolidine-2-carboxylic acid
CFAMM00301882 CHEMBL366456 Bioactive (3S)-5-(butylamino)-3-[2-[3-(naphthalene-2-carbonylamino)-2-oxopyridin-1-yl]butanoylamino]-4-oxopentanoic acid
CFAMM00301898 CHEMBL368313 Bioactive (3S)-3-[2-[3-(naphthalene-2-carbonylamino)-2-oxopyridin-1-yl]butanoylamino]-4-oxo-5-(3-phenylpropylamino)pentanoic acid
CFAMM00301911 CHEMBL173677 Bioactive (3S)-5-[butyl(methyl)amino]-3-[2-[3-(naphthalene-2-carbonylamino)-2-oxopyridin-1-yl]butanoylamino]-4-oxopentanoic acid
CFAMM00301916 DNC014548 Investigative Drug CR-1795

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27036 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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