CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID4062
Family Name DNA topoisomerase Inhibitor 6-p-tolylamino-1h-pyrimidine-2,4-dione Family
No. of Seeds 3 No. of Other Members 17
Family Centroid CFAMM00301983 Functional Category Investigative Drug
Superfamily DNA topoisomerase Binder Superfamily
Class Class 2986

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Sodium channel Ligand iminostilbene derivative (tricyclic stru... 2 46
Histone deacetylase 1 Inhibitor Vorinostat Family 26 138
Proto-oncogene tyrosine-protein kinase Src Inhibitor ISO24 Family 3 9
Urokinase-type plasminogen activator Inhibitor N-(1-adamantyl)... 2 15
Bifunctional epoxide hydrolase 2 Inhibitor 1-cyclohexyl-3-phen... 5 65
Tyrosine-protein phosphatase non-receptor type 1 Ligand [[4-(a... 1 7
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 14 78
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
Transient receptor potential cation channel subfamily V member... 6 33
Androgen receptor Ligand YM-175735 Family 30 129
Kinesin-like protein KIF11 Inhibitor N-{4'-[(trifluoromethyl)s... 3 1
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 7 134
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 1 16
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Tyrosinase Inhibitor S-2-(o-toluidino)-2-oxoethyl Carbamothioa... 1 1
Tyrosinase Inhibitor 1-hydroxy-3-(4-(trifluoromethyl)phenyl)ur... 2 3
DNA topoisomerase Inhibitor 6-(indan-5-ylamino)-1h-pyrimidine-... 2 0
DNA topoisomerase Inhibitor 6-(naphthalen-2-ylamino)-1h-pyrimi... 2 1
DNA polymerase Inhibitor 6-(4-bromo-phenylamino)-1h-pyrimidine... 2 1
DNA topoisomerase Inhibitor 6-(3-iodo-phenylamino)-1h-pyrimidi... 2 5
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor 1-(3,5... 2 0
DNA polymerase III PolC-type inhibitor HB-EMAU family 17 7
DNA polymerase III PolC-type inhibitor SureCN3470957 family 7 0
DNA polymerase III PolC-type inhibitor SureCN3473660 family 2 0
DNA polymerase III PolC-type inhibitor SureCN3471150 family 1 0
DNA polymerase III PolC-type inhibitor [5-[[3-(4-methoxybutyl)... 2 2
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 1 3
DNA polymerase III PolC-type inhibitor 6-(3-chloro-4-methylani... 1 1
DNA polymerase III PolC-type inhibitor 3-(4-hydroxybutyl)-6-(3... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00301983 DNC014572 Investigative Drug 6-p-Tolylamino-1H-pyrimidine-2,4-dione
CFAMM00301996 DNC014639 Investigative Drug 6-(3-Ethyl-phenylamino)-1H-pyrimidine-2,4-dione
CFAMM00302002 DNC014573 Investigative Drug 5-Bromo-6-p-tolylamino-1H-pyrimidine-2,4-dione

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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