CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID4065
Family Name Serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit Inhibitor MICROCYSTIN-LR Family
No. of Seeds 10 No. of Other Members 0
Family Centroid CFAMM00302018 Functional Category Investigative Drug
Superfamily Beta-secretase 1 and Caspase-4 Binder Superfamily
Class Class 608

Cousin Family NamesSeedsMembers
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
Bacterial outer membrane Inhibitor Polymyxin B Family 17 181
Thymopentin family 20 133
Thymosin Beta-4 family 8 30
Integrin alpha-V and Integrin beta-3 Inhibitor C[rgd-(s)-alpha... 19 95
Renin Inhibitor CP-80794 Family 16 112
Neuromedin-K receptor Ligand Senktide Family 15 22
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Beta-secretase 1 Inhibitor Glu-leu-asp-leu-(choh-ch2)-ala-ala-... 15 11
Calcitonin gene-related peptide type 1 receptor Ligand Fvptdvg... 8 8
Beta-secretase 1 Inhibitor KMI-172 Family 3 0
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Disks large homolog 4 Inhibitor N-(3,4-difluorophenyl)propyl-e... 3 0
Integrin alpha-V Inhibitor C[rgdf-(3s)-carboxymorpholine] Family 10 2
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
Genome polyprotein Inhibitor Acasp-glu-dif-glu-cha-cys Family 13 17
Genome polyprotein Inhibitor Acasp-glu-met-glu-cha-cys Family 3 6
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Genome polyprotein Inhibitor Acasp-glu-cha-val-prb-cys Family 13 18
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Renin inhibitor (2S,4S,5S)-N-butyl-6-cyclohexyl-4-hydroxy-5-[[... 12 1
Pol polyprotein inhibitor benzyl N-[(2S)-1-[[(2S,3S,4R,5S)-3,4... 21 5
Renin and Cathepsin D inhibitor (2S)-N-[(2S,3R,4S)-1-cyclohexy... 13 2
NS3 and Non-structural protein 4A inhibitor (4S)-4-[[(2S)-3-ca... 1 1
Pol polyprotein inhibitor benzyl N-[(2S)-4-amino-1-[[(2S,3R)-4... 2 1
Renin inhibitor 2-hydroxy-3-[[(4S,7S)-5-hydroxy-2,8-dimethyl-7... 1 0
Renin and Cathepsin D inhibitor ethyl (4S)-5-cyclohexyl-2,2-di... 2 0
Pol polyprotein inhibitor AC1L9R8I family 1 0
Histone deacetylase 1 and Histone deacetylase 8 inhibitor meth... 1 3
Ribonucleoside-diphosphate reductase large subunit and Ribonuc... 1 0
Bcl-2-like protein 1 inhibitor CHEMBL501005 family 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00302011 CHEMBL415297 Bioactive (2S,5S,6S,9R,14Z,17R,18S)-14-ethylidene-5-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dienyl]-6,13,18-trimethyl-3,7,12,15,19-pentaoxo-2-propan-2-yl-1,4,8,13-tetrazacyclononadecane-9,17-dicarboxylic acid
CFAMM00302017 CHEMBL430145 Bioactive AC1N9ZKX
CFAMM00302016 CHEMBL1159778 Bioactive (3R,11R,14S,15S,18S,21S,22R,25S)-3-(aminomethyl)-15-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dienyl]-7,14,18,21-tetramethyl-6-methylidene-25-(2-methylpropyl)-2,5,8,13,17,20,24-heptaoxo-1,4,7,12,16,19-hexazacyclopentacosane-11,22-dicarboxylic acid
CFAMM00302015 CHEMBL15785 Bioactive (3R,11R,14S,15S,18S,21S,22R,25S)-15-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dienyl]-3,7,14,18,21-pentamethyl-25-(2-methylpropyl)-2,5,8,13,17,20,24-heptaoxo-1,4,7,12,16,19-hexazacyclopentacosane-11,22-dicarboxylic acid
CFAMM00302014 CHEMBL17060 Bioactive (3R,11R,14S,15S,18S,21S,22R,25S)-25-(cyclohexylmethyl)-15-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dienyl]-3,7,14,18,21-pentamethyl-6-methylidene-2,5,8,13,17,20,24-heptaoxo-1,4,7,12,16,19-hexazacyclopentacosane-11,22-dicarboxylic acid
CFAMM00302020 CHEMBL17738 Bioactive Microcystin-LA
CFAMM00302013 CHEMBL385212 Bioactive (3R,11R,14S,15S,18S,21S,22R,25S)-7-cyclohexyl-15-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dienyl]-3,14,18,21-tetramethyl-25-(2-methylpropyl)-2,5,8,13,17,20,24-heptaoxo-1,4,7,12,16,19-hexazacyclopentacosane-11,22-dicarboxylic acid
CFAMM00302019 CHEMBL421377 Bioactive Cyanoginosin-LA
CFAMM00302012 CHEMBL108308 Bioactive Nodularin
CFAMM00302018 DNC014581 Investigative Drug MICROCYSTIN-LR

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

43653 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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