CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID4079
Family Name Liver carboxylesterase 1 Inhibitor SCH-48375 Family
No. of Seeds 2 No. of Other Members 28
Family Centroid CFAMM00302116 Functional Category Investigative Drug with Natural Product
Superfamily Liver carboxylesterase 1 and Voltage-dependent L-type calcium channel Binder Superfamily
Class Class 1560

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand phenylpiperazine derivative Arip... 3 53
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Multidrug resistance protein Inhibitor Benzquinamide Family 1 41
Niemann-Pick C1-like protein 1 Inhibitor Ezetimibe Family 1 4
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
D(2) dopamine receptor Ligand Pardoprunox Family 4 81
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Voltage-dependent L-type calcium channel Ligand Sq32,910 Family 1 25
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Potassium ... 1 15
Oxytocin receptor and Vasopressin V1a receptor Ligand L-371257... 8 92
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
Histamine H3 receptor Ligand A-349821 Family 49 228
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand RWJ-68141 Family 5 4
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 7 18
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Multidrug resistance protein 1 and Multidrug resistance-associ... 3 55
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Fatty-acid amide hydrolase 1 Inhibitor Phenylcarbamic Acid Bip... 3 7
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
D(2) dopamine receptor Ligand Epidepride Family 31 66
D(4) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 2 6
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 10
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Sodium-dependent serotonin transporter and D(2) dopamine recep... 4 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 4 6
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 4 2
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 8 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 2
Survival motor neuron protein and DNA-(apurinic or apyrimidini... 1 5
Voltage-dependent L-type calcium channel subunit alpha-1C and ... 1 6
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Neutrophil collagenase inhibitor (3R)-2-[4-[4-(dimethylamino)p... 2 4
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 1
Type-2 angiotensin II receptor ligand SureCN244657 family 7 11
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
Neuropeptide S receptor and Survival motor neuron protein liga... 1 2
Gastrin/cholecystokinin type B receptor ligand 1-[3-[[2-(3-met... 2 12
C5a anaphylatoxin chemotactic receptor 1 ligand N-[(4-dimethyl... 1 4
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor N-[(1S,5aR,9... 2 2
Potassium voltage-gated channel subfamily H member 2 and Melan... 2 12
Histamine H3 receptor ligand SureCN1373218 family 2 2
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 1 0
Histamine H3 receptor ligand 1-methyl-5-[4-[3-[(2R)-2-methylpy... 5 5
Histamine H3 receptor ligand 5-[4-[3-[(2R)-2-methylpyrrolidin-... 2 3
Renin and Cytochrome P450 3A4 inhibitor SureCN6719989 family 2 0
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
5-hydroxytryptamine receptor 1A and D(4) dopamine receptor lig... 1 0
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial ... 3 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 3
Cathepsin K inhibitor (1R,2R)-N-(cyanomethyl)-2-[4-(3-methoxyp... 2 1
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-(1-cyanocyclop... 4 0
Integrin beta-3 and Integrin alpha-2 inhibitor 3-(4-methoxyphe... 4 6
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Delta-type opioid receptor and Kappa-type opioid receptor liga... 5 0
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-(3-methoxy-2-me... 2 4
Neutrophil elastase inhibitor AGN-PC-04S1IE family 1 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 13
Sigma non-opioid intracellular receptor 1 ligand (5S)-5-[(4-hy... 1 5
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 12
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 1 0
Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 1 1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor AGN-PC-04F7M... 1 3
Aromatase inhibitor SureCN10351071 family 1 0
Histone deacetylase 1 and Histone deacetylase 2 inhibitor 4-[3... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 0
N-(4-acetamidophenyl)-2-(2,2-dimethyl-3,4-dihydrochromen-6-yl)... 1 0
4-(4-methoxyphenyl)-2,4,5,10-tetrahydro-1H-pyrrolo[3,4-c][1,5]... 4 0
10,10-dimethyl-3,4-dihydro-1H-pyrimido[1,2-a]indol-2-one NP (e... 14 0
(3R)-6,7-dimethoxy-1,2,3,4-tetrahydroquinoline-3-carboxylate N... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00302116 DNC014621 Investigative Drug SCH-48375

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27513 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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